STRINGSTRING
MAP2K2 MAP2K2 CASP9 CASP9 DAB2IP DAB2IP MAPK3 MAPK3 TRAF1 TRAF1 PIK3CD PIK3CD FASLG FASLG TRADD TRADD PIK3R2 PIK3R2 ERN1 ERN1 AIFM1 AIFM1 LOC420160 LOC420160 DIABLO DIABLO PARP3 PARP3 PIK3CB PIK3CB LMINA LMINA LOC425049 LOC425049 PDPK1 PDPK1 BCL2A1 BCL2A1 CTSD CTSD FADD FADD CFLAR CFLAR CASP8 CASP8 CASP7 CASP7 PIK3CA PIK3CA CAPN2 CAPN2 CTSO CTSO CYCS CYCS PTPN13 PTPN13 TUBA4B TUBA4B CASP6 CASP6 CSF2RB CSF2RB CTSV CTSV BCL2 BCL2 NTRK1 NTRK1 ITPR2 ITPR2 LMNB1 LMNB1 PIK3R3 PIK3R3 EIF2AK3 EIF2AK3 ATM ATM CTSC CTSC CASP2 CASP2 BIRC3 BIRC3 RIPK1 RIPK1 TUBA8B TUBA8B NFKB1 NFKB1 ATF4 ATF4 JUN JUN APAF1 APAF1 PARP1 PARP1 BIRC5 BIRC5 FAS FAS TUBAL3 TUBAL3 GADD45G GADD45G FOS FOS GADD45A GADD45A NFKBIA NFKBIA ENDOG ENDOG NRAS NRAS TUBA1A TUBA1A ENSGALP00000045024 ENSGALP00000045024 GADD45B GADD45B LOC100857858 LOC100857858 LOC768589 LOC768589 DFFB DFFB CTSK CTSK TUBA1B TUBA1B RAF1 RAF1 RELA RELA EIF2S1 EIF2S1 LOC776816 LOC776816 TUBA8A TUBA8A DDIT3 DDIT3 BID BID TNFRSF1A TNFRSF1A PMAIP1 PMAIP1 TUBA3E TUBA3E MAP2K1 MAP2K1 CAPN1 CAPN1 CTSZ CTSZ CHUK CHUK CTSH CTSH CAPN11 CAPN11 HTRA2 HTRA2 SEPT4 SEPT4 PARP4 PARP4 BCL2L1 BCL2L1 BAK1 BAK1 MAP3K5 MAP3K5 MAPK10 MAPK10 DFFA DFFA TUBA4A TUBA4A ACTB ACTB CTSB CTSB TNFSF10 TNFSF10 AKT3 AKT3 MCL1 MCL1 AKT2 AKT2 CASP18 CASP18 CTSS CTSS CRCBL CRCBL SPTAN1 SPTAN1 AKT1 AKT1 MAPK8 MAPK8 PIK3R1 PIK3R1 CASP3 CASP3 LMNA-2 LMNA-2 TRAF2 TRAF2 BCL2L11 BCL2L11 TNFRSF10B TNFRSF10B LMNA LMNA LRRC27 LRRC27 ITPR1 ITPR1 MAPK9 MAPK9 MAP3K14 MAP3K14 HRAS HRAS NGF NGF BIRC8 BIRC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). (398 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (418 aa)
DAB2IPDAB2 interacting protein. (1189 aa)
MAPK3Mitogen-activated protein kinase. (421 aa)
TRAF1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
FASLGTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (295 aa)
TRADDTNFRSF1A associated via death domain. (461 aa)
PIK3R2Uncharacterized protein. (731 aa)
ERN1Uncharacterized protein. (968 aa)
AIFM1Uncharacterized protein. (689 aa)
LOC420160Uncharacterized protein; Belongs to the peptidase C1 family. (336 aa)
DIABLOUncharacterized protein. (240 aa)
PARP3Poly [ADP-ribose] polymerase. (526 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
LMINAUncharacterized protein; Belongs to the intermediate filament family. (451 aa)
LOC425049Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
PDPK1Protein kinase domain-containing protein. (556 aa)
BCL2A1Protein A1. (174 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
FADDFas associated via death domain. (195 aa)
CFLARUncharacterized protein; Belongs to the peptidase C14A family. (493 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (309 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CAPN2Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (700 aa)
CTSOPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (320 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PTPN13Protein tyrosine phosphatase non-receptor type 13. (2515 aa)
TUBA4BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
CASP6Uncharacterized protein; Belongs to the peptidase C14A family. (317 aa)
CSF2RBUncharacterized protein. (678 aa)
CTSVCathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
NTRK1High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors that regulate distinct overlapping signali [...] (790 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2700 aa)
LMNB1Lamin-B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin; Belongs to the intermediate filament family. (650 aa)
PIK3R3Uncharacterized protein. (463 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1085 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
CTSCPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (532 aa)
CASP2Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. (441 aa)
BIRC3Inhibitor of apoptosis protein; Apoptotic suppressor. (610 aa)
RIPK1Uncharacterized protein. (682 aa)
TUBA8BTubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (446 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. (983 aa)
ATF4ATF4. (354 aa)
JUNTranscription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (310 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
PARP1Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...] (1011 aa)
BIRC5Uncharacterized protein. (142 aa)
FASUncharacterized protein. (339 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (459 aa)
GADD45GGrowth arrest and DNA-damage-inducible protein 45 gamma. (159 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
GADD45AGrowth arrest and DNA-damage-inducible protein 45 alpha. (157 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
ENDOGEndonuclease G. (201 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
ENSGALP00000045024Tubulin_C domain-containing protein. (223 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (169 aa)
LOC100857858Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
LOC768589Uncharacterized protein. (173 aa)
DFFBCaspase-activated DNase. (333 aa)
CTSKCathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). (334 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen- activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity). (667 aa)
RELATranscription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (315 aa)
LOC776816Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa)
TUBA8ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
DDIT3C/EBP-like protein. (155 aa)
BIDBH3-interacting domain death agonist; Induces caspases and apoptosis. Counters the protective effect of Bcl-2 (By similarity). (300 aa)
TNFRSF1AUncharacterized protein. (427 aa)
PMAIP1Uncharacterized protein. (54 aa)
TUBA3ETubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
CAPN1Uncharacterized protein; Belongs to the peptidase C2 family. (715 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (325 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (403 aa)
CAPN11Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase C2 family. (705 aa)
HTRA2HtrA serine peptidase 2. (200 aa)
SEPT4Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (476 aa)
PARP4Poly [ADP-ribose] polymerase. (1615 aa)
BCL2L1Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
BAK1Uncharacterized protein. (216 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1354 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
DFFADNA fragmentation factor subunit alpha. (312 aa)
TUBA4ATubulin alpha-5 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (499 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
CTSBCathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family. (360 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MCL1Uncharacterized protein. (335 aa)
AKT2Non-specific serine/threonine protein kinase. (881 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
CTSSUncharacterized protein; Belongs to the peptidase C1 family. (508 aa)
CRCBLFibronectin type-III domain-containing protein. (674 aa)
SPTAN1Spectrin alpha chain, non-erythrocytic 1; Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization. (2497 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
LMNA-2Lamin-B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin; Belongs to the intermediate filament family. (658 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
BCL2L11BCL2 like 11. (179 aa)
TNFRSF10BUncharacterized protein. (429 aa)
LMNALamin-A; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin; Belongs to the intermediate filament family. (270 aa)
LRRC27Death domain-containing protein. (291 aa)
ITPR1Uncharacterized protein. (2800 aa)
MAPK9Mitogen-activated protein kinase 9; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (424 aa)
MAP3K14Protein kinase domain-containing protein. (941 aa)
HRASGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
NGFBeta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. (284 aa)
BIRC8Inhibitor of apoptosis protein 3. (493 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.