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| | ADIPOR1 | Uncharacterized protein. (479 aa) |
| | AGRP | Agouti-related protein. (233 aa) |
| | TRADD | TNFRSF1A associated via death domain. (461 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa) |
| | ACSBG1 | Acyl-CoA synthetase bubblegum family member 1. (688 aa) |
| | MTOR | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation. (593 aa) |
| | IRS1 | Insulin receptor substrate 1. (1178 aa) |
| | ACSL3 | Acyl-CoA synthetase long chain family member 3. (713 aa) |
| | ADIPOQ | C1q domain-containing protein. (244 aa) |
| | PRKAG2 | Uncharacterized protein. (567 aa) |
| | ACSL6 | AMP-binding domain-containing protein. (698 aa) |
| | CPT1A | Carnitine palmitoyltransferase I; Belongs to the carnitine/choline acetyltransferase family. (770 aa) |
| | PRKAB1 | 5'AMP-activated protein kinase beta-1 non-catalytic subunit. (273 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase [...] (622 aa) |
| | ACSL4 | Acyl-CoA synthetase long chain family member 4. (670 aa) |
| | IRS4 | Insulin receptor substrate 4. (1164 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | G6PC2 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa) |
| | NPY | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (560 aa) |
| | LEPR | Uncharacterized protein. (1148 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. (983 aa) |
| | PRKAG3 | Uncharacterized protein. (382 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...] (209 aa) |
| | PPY | Pancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. (80 aa) |
| | ADIPOR2 | Uncharacterized protein. (386 aa) |
| | ACSBG2 | Long-chain-fatty-acid--CoA ligase ACSBG2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. (745 aa) |
| | RXRA | Retinoid X receptor alpha. (467 aa) |
| | RELA | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa) |
| | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. (490 aa) |
| | TNFRSF1A | Uncharacterized protein. (427 aa) |
| | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa) |
| | PRKAB2 | 5'-AMP-activated protein kinase beta-2 non-catalytic subunit transcript variant 2. (274 aa) |
| | PPARA | Uncharacterized protein. (468 aa) |
| | PPARGC1A | RRM domain-containing protein. (795 aa) |
| | PRKAG1 | 5'-AMP-activated protein kinase gamma-1 non-catalytic subunit variant 1. (298 aa) |
| | CAMKK2 | Protein kinase domain-containing protein. (513 aa) |
| | STK11 | Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity). (426 aa) |
| | TNFRSF1B | Uncharacterized protein. (462 aa) |
| | G6PC | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | ACACB | Uncharacterized protein. (879 aa) |
| | ACSL1 | AMP-binding domain-containing protein. (699 aa) |
| | LOC419429 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | POMC | Uncharacterized protein. (251 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (881 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | G6PC3 | Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (342 aa) |
| | RXRG | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). (469 aa) |
| | CD36 | Uncharacterized protein; Belongs to the CD36 family. (471 aa) |
| | ACSL5 | AMP-binding domain-containing protein. (683 aa) |
| | NFKBIE | NFKB inhibitor epsilon. (363 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Facilitates the recycling of lactate carbon in the liver. (414 aa) |
| | MAPK9 | Mitogen-activated protein kinase 9; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (424 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa) |
