(78 nodes) Endocytosis network (Guillardia theta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VPS20	Vacuolar protein sorting protein 20. (308 aa)
	L1I6G4_GUITC	Uncharacterized protein. (221 aa)
	L1I7J8_GUITC	Heat shock protein 70-like protein. (691 aa)
	VPS36	Vacuolar protein sorting 36. (259 aa)
	L1IA78_GUITC	AAA domain-containing protein; Belongs to the AAA ATPase family. (225 aa)
	L1IBB8_GUITC	Heat shock protein 70-like protein. (735 aa)
	VPS4	Vacuolar protein sorting protein 4; Belongs to the AAA ATPase family. (443 aa)
	L1IG09_GUITC	Uncharacterized protein. (238 aa)
	L1IGC1_GUITC	Uncharacterized protein. (238 aa)
	L1IGW3_GUITC	Heat shock protein 70; Belongs to the heat shock protein 70 family. (564 aa)
	L1IHZ3_GUITC	Heat shock protein 70-like protein. (358 aa)
	L1IIY9_GUITC	Heat shock protein 70-like protein; Belongs to the heat shock protein 70 family. (657 aa)
	L1IJ14_GUITC	PIPK domain-containing protein. (328 aa)
	VPS23B	Vacuolar protein sorting 23B. (338 aa)
	L1IKL8_GUITC	Arf GTPase activating protein. (259 aa)
	VPS25	Vacuolar protein sorting 25. (181 aa)
	VPS32	Vacuolar protein sorting protein 32. (228 aa)
	L1IPG5_GUITC	Uncharacterized protein. (209 aa)
	L1IQE9_GUITC	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (335 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (728 aa)
	L1IRL8_GUITC	SEC7 domain-containing protein. (1491 aa)
	VPS26B	Vacuolar protein sorting 26B. (348 aa)
	L1IRR7_GUITC	Uncharacterized protein. (222 aa)
	VPS24	Vacuolar protein sorting protein 24. (225 aa)
	L1ITE0_GUITC	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (144 aa)
	VPS29	Vacuolar protein sorting-associated protein 29; Belongs to the VPS29 family. (186 aa)
	CHC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1728 aa)
	L1J2N4_GUITC	SEC7 domain-containing protein. (1329 aa)
	L1J2V3_GUITC	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
	L1J326_GUITC	WD_REPEATS_REGION domain-containing protein. (369 aa)
	L1J391_GUITC	Heat shock protein 70-like protein. (384 aa)
	L1J4S8_GUITC	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (670 aa)
	L1J5A7_GUITC	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	L1J5D4_GUITC	Uncharacterized protein. (218 aa)
	L1J612_GUITC	Hsp70, chloroplastic; Belongs to the heat shock protein 70 family. (580 aa)
	L1J6D4_GUITC	Uncharacterized protein. (204 aa)
	L1J6D8_GUITC	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
	VPS2B	Vacuolar protein sorting 2B. (198 aa)
	AP2M	Adaptor protein complex 2 subunit MU; Belongs to the adaptor complexes medium subunit family. (426 aa)
	VPS46	Vacuolar protein sorting protein 46. (204 aa)
	L1J9X1_GUITC	Uncharacterized protein. (874 aa)
	L1JCJ9_GUITC	Heat shock protein 70; Belongs to the heat shock protein 70 family. (650 aa)
	L1JCW3_GUITC	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (124 aa)
	L1JD04_GUITC	Uncharacterized protein. (206 aa)
	L1JD81_GUITC	Heat shock protein 70; Belongs to the heat shock protein 70 family. (651 aa)
	L1JDG0_GUITC	SEC7 domain-containing protein. (1577 aa)
	L1JFF4_GUITC	Uncharacterized protein. (399 aa)
	VPS45A	Vacuolar protein sorting 45A; Belongs to the STXBP/unc-18/SEC1 family. (607 aa)
	VPS31	Vacuolar protein sorting protein 31. (984 aa)
	L1JGJ1_GUITC	Uncharacterized protein. (149 aa)
	L1JHN6_GUITC	PIPK domain-containing protein. (470 aa)
	L1JI74_GUITC	Uncharacterized protein. (214 aa)
	L1JID0_GUITC	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (414 aa)
	L1JII6_GUITC	Uncharacterized protein. (621 aa)
	L1JK08_GUITC	Heat shock protein 70-like protein; Belongs to the heat shock protein 70 family. (586 aa)
	L1JLI7_GUITC	Uncharacterized protein. (1018 aa)
	L1JLR9_GUITC	Uncharacterized protein. (1142 aa)
	L1JM32_GUITC	Uncharacterized protein. (203 aa)
	VPS26A	Vacuolar protein sorting 26A. (300 aa)
	AP2S	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
	VPS22	Vacuolar protein sorting 22. (243 aa)
	L1JQK0_GUITC	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (310 aa)
	L1JRQ5_GUITC	PX domain-containing protein. (447 aa)
	L1JSH8_GUITC	Heat shock protein 70; Belongs to the heat shock protein 70 family. (651 aa)
	L1JTE1_GUITC	SH3 domain-containing protein. (288 aa)
	VPS23A	Vacuolar sorting protein 23A. (333 aa)
	L1JUX4_GUITC	SEC7 domain-containing protein. (1596 aa)
	L1JVS3_GUITC	PIPK domain-containing protein. (596 aa)
	L1JVY2_GUITC	Uncharacterized protein. (908 aa)
	L1JZN8_GUITC	Uncharacterized protein. (230 aa)
	VPS28	Vacuolar sorting protein 28; Belongs to the VPS28 family. (215 aa)
	AP2A1	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (966 aa)
	VPS2A	Vacuolar protein sorting 2A. (212 aa)
	VPS60	Vacuolar protein sorting protein 60. (223 aa)
	VPS45B	Vacuolar protein sorting 45B; Belongs to the STXBP/unc-18/SEC1 family. (591 aa)
	L1K2H7_GUITC	Heat shock protein 70-like protein; Belongs to the heat shock protein 70 family. (574 aa)
	L1K2I4_GUITC	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (262 aa)
	VTA1	Vps20-associated 1. (327 aa)

Your Current Organism:

Guillardia theta

NCBI taxonomy Id: 905079
Other names: G. theta CCMP2712, Guillardia theta CCMP2712

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2M	L1K0K8	L1J965	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Adaptor protein complex 2 subunit MU; Belongs to the adaptor complexes medium subunit family.	0.999
AP2A1	AP2S	L1K0K8	L1JN93	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.995
AP2A1	CHC	L1K0K8	L1J231	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.971
AP2A1	L1J2V3_GUITC	L1K0K8	L1J2V3	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.543
AP2A1	L1J5A7_GUITC	L1K0K8	L1J5A7	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.494
AP2A1	L1J5D4_GUITC	L1K0K8	L1J5D4	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein.	0.533
AP2A1	L1J6D4_GUITC	L1K0K8	L1J6D4	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein.	0.562
AP2A1	L1J6D8_GUITC	L1K0K8	L1J6D8	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.494
AP2A1	L1JM32_GUITC	L1K0K8	L1JM32	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein.	0.494
AP2A1	L1JRQ5_GUITC	L1K0K8	L1JRQ5	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	PX domain-containing protein.	0.490
AP2A1	VPS29	L1K0K8	L1J1U9	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Vacuolar protein sorting-associated protein 29; Belongs to the VPS29 family.	0.629
AP2M	AP2A1	L1J965	L1K0K8	Adaptor protein complex 2 subunit MU; Belongs to the adaptor complexes medium subunit family.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.999
AP2M	AP2S	L1J965	L1JN93	Adaptor protein complex 2 subunit MU; Belongs to the adaptor complexes medium subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2M	CHC	L1J965	L1J231	Adaptor protein complex 2 subunit MU; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.944
AP2M	L1J2V3_GUITC	L1J965	L1J2V3	Adaptor protein complex 2 subunit MU; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.547
AP2S	AP2A1	L1JN93	L1K0K8	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.995
AP2S	AP2M	L1JN93	L1J965	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Adaptor protein complex 2 subunit MU; Belongs to the adaptor complexes medium subunit family.	0.999
AP2S	CHC	L1JN93	L1J231	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.878
AP2S	L1IKL8_GUITC	L1JN93	L1IKL8	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Arf GTPase activating protein.	0.432
AP2S	L1J2V3_GUITC	L1JN93	L1J2V3	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.446