node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GEAM_0249 | GEAM_1796 | GEAM_0249 | GEAM_1796 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | 0.593 |
GEAM_0249 | dinG | GEAM_0249 | GEAM_0904 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | ATP-dependent helicase; DNA-dependent ATPase and 5'-3' DNA helicase. | 0.593 |
GEAM_0249 | polA | GEAM_0249 | GEAM_3689 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.952 |
GEAM_0249 | rapA | GEAM_0249 | GEAM_0248 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | RapA family RNA polymerase-associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.816 |
GEAM_0249 | recQ | GEAM_0249 | GEAM_3843 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | ATP-dependent DNA helicase; Protein involved in nucleic acid binding, ATP binding, helicase activity, ATP-dependent helicase activity, ATP-dependent 3'-5' DNA helicase activity, ATP-dependent DNA helicase activity, nucleotide binding, catalytic activity, DNA recombination, DNA repair, DNA replication, SOS response and cellular metabolic process. | 0.542 |
GEAM_0249 | sbcC | GEAM_0249 | GEAM_2776 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | SbcC family exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SMC family. SbcC subfamily. | 0.652 |
GEAM_0249 | sbcD | GEAM_0249 | GEAM_2775 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | SbcD family exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.534 |
GEAM_0249 | topA | GEAM_0249 | GEAM_1948 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.419 |
GEAM_0249 | xni | GEAM_0249 | GEAM_2934 | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | DNA polymerase I; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. | 0.908 |
GEAM_1796 | GEAM_0249 | GEAM_1796 | GEAM_0249 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | DNA polymerase II; Protein involved in DNA-directed DNA polymerase activity, nucleotide binding, DNA binding, nucleic acid binding, DNA replication and nucleobase-containing compound metabolic process. | 0.593 |
GEAM_1796 | GEAM_2350 | GEAM_1796 | GEAM_2350 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | Superfamily II DNA/RNA helicase; Protein involved in ATP binding, DNA binding, hydrolase activity, helicase activity, nucleic acid binding, structural constituent of ribosome and translation. | 0.930 |
GEAM_1796 | polA | GEAM_1796 | GEAM_3689 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.800 |
GEAM_1796 | rapA | GEAM_1796 | GEAM_0248 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | RapA family RNA polymerase-associated protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.675 |
GEAM_1796 | recQ | GEAM_1796 | GEAM_3843 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | ATP-dependent DNA helicase; Protein involved in nucleic acid binding, ATP binding, helicase activity, ATP-dependent helicase activity, ATP-dependent 3'-5' DNA helicase activity, ATP-dependent DNA helicase activity, nucleotide binding, catalytic activity, DNA recombination, DNA repair, DNA replication, SOS response and cellular metabolic process. | 0.557 |
GEAM_1796 | sbcC | GEAM_1796 | GEAM_2776 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | SbcC family exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SMC family. SbcC subfamily. | 0.477 |
GEAM_1796 | sbcD | GEAM_1796 | GEAM_2775 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | SbcD family exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. | 0.762 |
GEAM_1796 | topA | GEAM_1796 | GEAM_1948 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.583 |
GEAM_1796 | xni | GEAM_1796 | GEAM_2934 | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | DNA polymerase I; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. | 0.644 |
GEAM_2350 | GEAM_1796 | GEAM_2350 | GEAM_1796 | Superfamily II DNA/RNA helicase; Protein involved in ATP binding, DNA binding, hydrolase activity, helicase activity, nucleic acid binding, structural constituent of ribosome and translation. | DinG family ATP-dependent helicase; Protein involved in hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, ATP-dependent helicase activity, nucleic acid binding, ATP binding, DNA binding, hydrolase activity, ATP-dependent DNA helicase activity and nucleobase-containing compound metabolic process. | 0.930 |
GEAM_2350 | dinG | GEAM_2350 | GEAM_0904 | Superfamily II DNA/RNA helicase; Protein involved in ATP binding, DNA binding, hydrolase activity, helicase activity, nucleic acid binding, structural constituent of ribosome and translation. | ATP-dependent helicase; DNA-dependent ATPase and 5'-3' DNA helicase. | 0.930 |