STRINGSTRING
EDX83653.1 EDX83653.1 clpP clpP EDX83820.1 EDX83820.1 EDX83856.1 EDX83856.1 EDX83958.1 EDX83958.1 EDX84150.1 EDX84150.1 clpB clpB EDX84286.1 EDX84286.1 dnaK dnaK hrcA hrcA clpX clpX EDX84407.1 EDX84407.1 groL groL EDX84804.1 EDX84804.1 groL-2 groL-2 EDX84999.1 EDX84999.1 EDX85005.1 EDX85005.1 EDX85284.1 EDX85284.1 clpP-2 clpP-2 clpP-3 clpP-3 EDX85639.1 EDX85639.1 EDX85702.1 EDX85702.1 dnaK-2 dnaK-2 clpB-2 clpB-2 groL-3 groL-3 clpS clpS S7335_415 S7335_415 EDX86759.1 EDX86759.1 EDX86785.1 EDX86785.1 dnaK-3 dnaK-3 groS groS grpE grpE dnaJ dnaJ clpP-4 clpP-4 EDX87780.1 EDX87780.1 EDX87859.1 EDX87859.1 S7335_665 S7335_665
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDX83653.1DnaJ domain protein; [O] COG2214 DnaJ-class molecular chaperone. (358 aa)
clpPATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (269 aa)
EDX83820.1Hydrolase, alpha/beta fold family, putative; [R] COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily). (289 aa)
EDX83856.1ATP-dependent Clp protease adaptor protein ClpS; [S] COG2127 Uncharacterized conserved protein; Belongs to the ClpS family. (71 aa)
EDX83958.1Tryptophan/tyrosine permease family; [E] COG0814 Amino acid permeases. (355 aa)
EDX84150.1Lipase superfamily; [R] COG1075 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold. (203 aa)
clpBATPase, AAA family; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (871 aa)
EDX84286.1Pyridoxal-dependent decarboxylase conserved domain, putative; [E] COG0076 Glutamate decarboxylase and related PLP-dependent proteins. (488 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (710 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (364 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (443 aa)
EDX84407.1[OU] COG0740 Protease subunit of ATP-dependent Clp proteases; Belongs to the peptidase S14 family. (230 aa)
groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
EDX84804.1[M] COG0818 Diacylglycerol kinase. (210 aa)
groL-2Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (523 aa)
EDX84999.1Hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. (1263 aa)
EDX85005.1ATPase, AAA family; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. (826 aa)
EDX85284.1DnaJ domain protein. (180 aa)
clpP-2ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (201 aa)
clpP-3Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (200 aa)
EDX85639.1Hypothetical protein; [NT] COG0840 Methyl-accepting chemotaxis protein. (749 aa)
EDX85702.1DnaJ C terminal region domain protein; [O] COG2214 DnaJ-class molecular chaperone. (350 aa)
dnaK-2Chaperone protein DnaK, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. (924 aa)
clpB-2ATPase, AAA family; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. (941 aa)
groL-3Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (559 aa)
clpSATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (97 aa)
S7335_415Hypothetical protein; [O] COG0576 Molecular chaperone GrpE (heat shock protein). (152 aa)
EDX86759.1Conserved hypothetical protein TIGR00147; [IR] COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase. (321 aa)
EDX86785.1DnaJ domain protein; [S] COG1357 Uncharacterized low-complexity proteins. (411 aa)
dnaK-3Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (635 aa)
groSChaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (104 aa)
grpECo-chaperone GrpE, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of [...] (239 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (376 aa)
clpP-4Clp protease; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (218 aa)
EDX87780.1ATPase, AAA family; [O] COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. (822 aa)
EDX87859.1ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein; Molecular chaperone. Has ATPase activity. (658 aa)
S7335_665MerR, DNA binding family; [K] COG0789 Predicted transcriptional regulators. (401 aa)
Your Current Organism:
Synechococcus sp. PCC7335
NCBI taxonomy Id: 91464
Other names: Coccusdissimilis mexicanus PCC 7335, S. sp. PCC 7335, Synechococcus PCC 7335, Synechococcus PCC7335, Synechococcus mexicanus PCC 7335, Synechococcus sp. PCC 7335
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