(144 nodes) Protein folding, and Response to topologically incorrect protein network (Parus major)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PFDN1	Prefoldin subunit 1 isoform X1. (122 aa)
	DNAJC5G	DnaJ homolog subfamily C member 5G. (266 aa)
	DNAJC5B	DnaJ homolog subfamily C member 5B. (182 aa)
	ERN2	Serine/threonine-protein kinase/endoribonuclease IRE1. (698 aa)
	CHORDC1	Cysteine and histidine-rich domain-containing protein 1. (331 aa)
	MKKS	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (572 aa)
	CCT3	T-complex protein 1 subunit gamma. (571 aa)
	DNAJC7	DnaJ homolog subfamily C member 7. (500 aa)
	HSF4	Heat shock factor protein 4 isoform X1. (528 aa)
	HSPA2	Heat shock-related 70 kDa protein 2. (634 aa)
	DNAJB13	DnaJ homolog subfamily B member 13 isoform X1. (316 aa)
	LDLRAD1	Low-density lipoprotein receptor class A domain-containing protein 1. (179 aa)
	TMEM59	Transmembrane protein 59 isoform X1. (398 aa)
	HIKESHI	Protein Hikeshi isoform X1. (197 aa)
	HSPA14	Heat shock 70 kDa protein 14. (505 aa)
	PTGES3L	Putative protein PTGES3L. (141 aa)
	ERMARD	Endoplasmic reticulum membrane-associated RNA degradation protein isoform X1. (666 aa)
	ENSPMJP00000002775	annotation not available (72 aa)
	EDEM2	ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1. (579 aa)
	CDC42SE2	CDC42 small effector protein 2. (84 aa)
	DNAJA2	DnaJ homolog subfamily A member 2 isoform X1. (437 aa)
	LOC107204317	Heat shock 70 kDa protein 12B-like. (579 aa)
	CALR	Calreticulin. (558 aa)
	STIP1	Stress induced phosphoprotein 1. (365 aa)
	FKBP4	Peptidyl-prolyl cis-trans isomerase FKBP4. (449 aa)
	HSPD1	60 kDa heat shock protein, mitochondrial. (573 aa)
	HSPE1	Heat shock protein family E (Hsp10) member 1. (96 aa)
	TOMM34	Mitochondrial import receptor subunit TOM34. (323 aa)
	ERO1B	ERO1-like protein beta. (468 aa)
	CCT7	T-complex protein 1 subunit eta. (706 aa)
	NKTR	NK-tumor recognition protein isoform X1. (1481 aa)
	DNAJC2	DnaJ homolog subfamily C member 2. (620 aa)
	FBXW4	F-box/WD repeat-containing protein 4 isoform X1. (408 aa)
	DNAJA1	DnaJ homolog subfamily A member 1. (397 aa)
	CRELD1	Cysteine rich with EGF like domains 1. (428 aa)
	HSPA9	Stress-70 protein, mitochondrial. (641 aa)
	PTGES3	Prostaglandin E synthase 3. (277 aa)
	MANF	Mesencephalic astrocyte-derived neurotrophic factor. (271 aa)
	DNAJB5	DnaJ homolog subfamily B member 5 isoform X1. (381 aa)
	DNAJC25	DnaJ homolog subfamily C member 25. (351 aa)
	DNAJB6	DnaJ homolog subfamily B member 6 isoform X2. (328 aa)
	HSPA12A	Heat shock 70 kDa protein 12A. (666 aa)
	FAM204A	Protein FAM204A isoform X1. (250 aa)
	BAG3	BAG family molecular chaperone regulator 3. (560 aa)
	EDEM1	ER degradation-enhancing alpha-mannosidase-like protein 1. (605 aa)
	NR3C1	Glucocorticoid receptor. (773 aa)
	CCT5	T-complex protein 1 subunit epsilon. (541 aa)
	HSPA4	Heat shock 70 kDa protein 4. (837 aa)
	GRPEL2	GrpE protein homolog 2, mitochondrial. (224 aa)
	DNAJC5	DnaJ homolog subfamily C member 5. (198 aa)
	SIL1	Nucleotide exchange factor SIL1-like. (318 aa)
	HYOU1	Hypoxia up-regulated protein 1. (994 aa)
	ATF4	Cyclic AMP-dependent transcription factor ATF-4. (354 aa)
	HSPA4L	Heat shock 70 kDa protein 4L. (843 aa)
	LOC107204016	Heat shock factor protein 3-like isoform X1. (558 aa)
	DNAJC18	DnaJ homolog subfamily C member 18. (296 aa)
	CLGN	Calmegin isoform X1. (633 aa)
	CANX	Calnexin. (604 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (288 aa)
	DNAJA4	DnaJ homolog subfamily A member 4 isoform X1. (224 aa)
	DNAJA3	DnaJ homolog subfamily A member 3, mitochondrial. (548 aa)
	TTC12	Tetratricopeptide repeat protein 12 isoform X1. (703 aa)
	HSPB2	Heat shock protein beta-2. (181 aa)
	HSPA8	Heat shock cognate 71 kDa protein. (660 aa)
	NR3C2	Mineralocorticoid receptor isoform X1. (982 aa)
	TMEM184C	Transmembrane protein 184C. (445 aa)
	HSP90B1	Heat shock protein 90kDa beta. (841 aa)
	BAG2	BAG family molecular chaperone regulator 2. (224 aa)
	PFDN4	Prefoldin subunit 4. (135 aa)
	TCP1	T-complex protein 1 subunit alpha. (559 aa)
	CRELD2	Cysteine-rich with EGF-like domain protein 2. (370 aa)
	HSPB7	Heat shock protein beta-7. (178 aa)
	DNAJB14	DnaJ homolog subfamily B member 14 isoform X1. (397 aa)
	ENSPMJP00000012848	Heat shock transcription factor, Y-linked-like isoform X1. (136 aa)
	LOC107214510	DnaJ homolog subfamily A member 1-like. (407 aa)
	TRAP1	Heat shock protein 75 kDa, mitochondrial. (830 aa)
	TXNDC11	Thioredoxin domain-containing protein 11 isoform X2. (913 aa)
	DNAJC11	DnaJ homolog subfamily C member 11 isoform X1. (574 aa)
	DNAJB9	DnaJ homolog subfamily B member 9. (221 aa)
	HDAC9	Histone deacetylase 9 isoform X1. (1107 aa)
	PRDX4	Peroxiredoxin-4 isoform X1. (279 aa)
	VBP1	Prefoldin subunit 3 isoform X1. (197 aa)
	TMEM59L	Transmembrane protein 59 like. (282 aa)
	ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha. (526 aa)
	CCT8	T-complex protein 1 subunit theta isoform X1. (553 aa)
	PDIA3	Protein disulfide-isomerase A3. (555 aa)
	CLPB	ATP-dependent Clp protease ATP-binding subunit ClpB. (769 aa)
	HSPA13	Stress 70 protein chaperone microsome-associated 60kDa protein. (472 aa)
	FKBP5	Peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1. (509 aa)
	PDIA6	Protein disulfide-isomerase A6. (442 aa)
	CCT2	T-complex protein 1 subunit beta. (535 aa)
	ENSPMJP00000016991	annotation not available (59 aa)
	DNAJB8	DnaJ homolog subfamily B member 8. (146 aa)
	UGGT2	UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1. (1540 aa)
	DNAJC3	DnaJ homolog subfamily C member 3 isoform X1. (504 aa)
	TTC28	Tetratricopeptide repeat protein 28 isoform X1. (2464 aa)
	XBP1	LOW QUALITY PROTEIN: X-box-binding protein 1. (232 aa)
	BAG1	BAG family molecular chaperone regulator 1. (209 aa)
	HSF2	Heat shock transcription factor 2. (573 aa)
	CSNK2A2	Casein kinase 2 alpha 2. (366 aa)
	ERP44	Endoplasmic reticulum resident protein 44 isoform X1. (451 aa)
	SDF2L1	Stromal cell-derived factor 2-like protein 1. (214 aa)
	AHSA2P	Activator of 90 kDa heat shock protein ATPase homolog 2 isoform X1. (382 aa)
	FAM161A	Protein FAM161A isoform X1. (751 aa)
	CCT4	T-complex protein 1 subunit delta. (537 aa)
	HSP90AB1	LOW QUALITY PROTEIN: heat shock protein HSP 90-beta. (731 aa)
	SUGT1	Suppressor of G2 allele of SKP1. (498 aa)
	EIF2AK2	Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (551 aa)
	PDCL3	Phosducin-like protein 3. (240 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2-alpha kinase 4. (1751 aa)
	TXNDC9	Thioredoxin domain-containing protein 9. (226 aa)
	P4HB	Protein disulfide-isomerase A1. (640 aa)
	DNAJB12	DnaJ homolog subfamily B member 12 isoform X1. (374 aa)
	HSPB3	Heat shock protein beta-3. (149 aa)
	CDC37L1	Hsp90 co-chaperone Cdc37-like 1. (592 aa)
	PPP2R2C	Protein phosphatase 2, regulatory subunit B, gamma isoform X1. (456 aa)
	GRPEL1	GrpE protein homolog 1, mitochondrial. (222 aa)
	UGGT1	UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1. (1595 aa)
	DNAJB11	DnaJ homolog subfamily B member 11. (358 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1087 aa)
	AHSA1	Activator of 90 kDa heat shock protein ATPase homolog 1. (340 aa)
	HSP90AA1	Heat shock protein HSP 90-alpha. (728 aa)
	HSPB8	Heat shock protein beta-8. (201 aa)
	HSPH1	Heat shock protein 105 kDa isoform X1. (858 aa)
	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1. (961 aa)
	PDIA4	Protein disulfide-isomerase A4. (650 aa)
	ENSPMJP00000024626	Meteorin-like protein isoform X1. (114 aa)
	TXNDC5	Thioredoxin domain-containing protein 5. (377 aa)
	DNAJC10	DnaJ homolog subfamily C member 10. (797 aa)
	NFE2L2	Nuclear factor erythroid 2-related factor 2 isoform X1. (822 aa)
	PDC	Phosducin. (79 aa)
	PDC-2	Phosducin. (191 aa)
	PPIG	Peptidyl-prolyl isomerase G (cyclophilin G). (754 aa)
	DNAJC30	DnaJ homolog subfamily C member 30. (207 aa)
	CCT6B	T-complex protein 1 subunit zeta. (530 aa)
	SDF2	Stromal cell-derived factor 2. (196 aa)
	HSPA5	Endoplasmic reticulum chaperone BiP. (730 aa)
	EDEM3	ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1. (950 aa)
	ENSPMJP00000026646	annotation not available (69 aa)
	DNAJB4	DnaJ homolog subfamily B member 4. (339 aa)
	HSPA12B	Heat shock 70 kDa protein 12B. (909 aa)
	PLAAT1	Phospholipid-metabolizing enzyme A-C1. (167 aa)
	DNAJB2	DnaJ homolog subfamily B member 2 isoform X1. (282 aa)
	PDIA5	Protein disulfide-isomerase A5. (516 aa)

Your Current Organism:

Parus major

NCBI taxonomy Id: 9157
Other names: Great Tit, Kohlmeise, P. major

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSA1	CCT7	ENSPMJP00000022770	ENSPMJP00000004818	Activator of 90 kDa heat shock protein ATPase homolog 1.	T-complex protein 1 subunit eta.	0.508
AHSA1	CCT8	ENSPMJP00000022770	ENSPMJP00000015845	Activator of 90 kDa heat shock protein ATPase homolog 1.	T-complex protein 1 subunit theta isoform X1.	0.409
AHSA1	CDC37L1	ENSPMJP00000022770	ENSPMJP00000021841	Activator of 90 kDa heat shock protein ATPase homolog 1.	Hsp90 co-chaperone Cdc37-like 1.	0.589
AHSA1	CHORDC1	ENSPMJP00000022770	ENSPMJP00000000566	Activator of 90 kDa heat shock protein ATPase homolog 1.	Cysteine and histidine-rich domain-containing protein 1.	0.444
AHSA1	CLPB	ENSPMJP00000022770	ENSPMJP00000015997	Activator of 90 kDa heat shock protein ATPase homolog 1.	ATP-dependent Clp protease ATP-binding subunit ClpB.	0.546
AHSA1	DNAJA1	ENSPMJP00000022770	ENSPMJP00000005564	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily A member 1.	0.457
AHSA1	DNAJA2	ENSPMJP00000022770	ENSPMJP00000003297	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily A member 2 isoform X1.	0.457
AHSA1	DNAJA3	ENSPMJP00000022770	ENSPMJP00000010875	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily A member 3, mitochondrial.	0.468
AHSA1	DNAJA4	ENSPMJP00000022770	ENSPMJP00000010843	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily A member 4 isoform X1.	0.457
AHSA1	DNAJB13	ENSPMJP00000022770	ENSPMJP00000001851	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily B member 13 isoform X1.	0.498
AHSA1	DNAJB4	ENSPMJP00000022770	ENSPMJP00000026672	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily B member 4.	0.498
AHSA1	DNAJB5	ENSPMJP00000022770	ENSPMJP00000006195	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily B member 5 isoform X1.	0.497
AHSA1	DNAJB9	ENSPMJP00000022770	ENSPMJP00000014242	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily B member 9.	0.496
AHSA1	DNAJC10	ENSPMJP00000022770	ENSPMJP00000025003	Activator of 90 kDa heat shock protein ATPase homolog 1.	DnaJ homolog subfamily C member 10.	0.412
AHSA1	FKBP4	ENSPMJP00000022770	ENSPMJP00000004217	Activator of 90 kDa heat shock protein ATPase homolog 1.	Peptidyl-prolyl cis-trans isomerase FKBP4.	0.551
AHSA1	FKBP5	ENSPMJP00000022770	ENSPMJP00000016387	Activator of 90 kDa heat shock protein ATPase homolog 1.	Peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1.	0.453
AHSA1	HSP90AA1	ENSPMJP00000022770	ENSPMJP00000023438	Activator of 90 kDa heat shock protein ATPase homolog 1.	Heat shock protein HSP 90-alpha.	0.762
AHSA1	HSP90AB1	ENSPMJP00000022770	ENSPMJP00000019836	Activator of 90 kDa heat shock protein ATPase homolog 1.	LOW QUALITY PROTEIN: heat shock protein HSP 90-beta.	0.762
AHSA1	HSP90B1	ENSPMJP00000022770	ENSPMJP00000011390	Activator of 90 kDa heat shock protein ATPase homolog 1.	Heat shock protein 90kDa beta.	0.781
AHSA1	HSPA2	ENSPMJP00000022770	ENSPMJP00000001681	Activator of 90 kDa heat shock protein ATPase homolog 1.	Heat shock-related 70 kDa protein 2.	0.449