(96 nodes) Mixed, incl. Tryptophan catabolism, and Nucleotide-sugar transmembrane transporter activity network (Exophiala spinifera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV08_12063	Uncharacterized protein. (469 aa)
	PV08_12044	Uncharacterized protein. (469 aa)
	PV08_11817	Uncharacterized protein. (355 aa)
	PV08_11369	Dipeptidyl peptidase 3; Belongs to the peptidase M49 family. (711 aa)
	PV08_10877	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (382 aa)
	PV08_09250	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (410 aa)
	PV08_09522	TPT domain-containing protein. (355 aa)
	PV08_09813	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. (523 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (495 aa)
	PV08_08699	Aminotran_1_2 domain-containing protein. (630 aa)
	PV08_07290	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (338 aa)
	PV08_07803	TPT domain-containing protein. (378 aa)
	PV08_05211	Cupin_2 domain-containing protein. (152 aa)
	PV08_03849	EamA domain-containing protein. (583 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (184 aa)
	PV08_04317	Peptidase_S9 domain-containing protein. (663 aa)
	PV08_04523	Uncharacterized protein; Belongs to the peptidase M24B family. (617 aa)
	PV08_04791	M16C_associated domain-containing protein. (1036 aa)
	PV08_02584	TPT domain-containing protein. (544 aa)
	BNA5-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (465 aa)
	PV08_00926	TPT domain-containing protein. (376 aa)
	PV08_01650	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (235 aa)
	PV08_01675	Uncharacterized protein. (326 aa)
	PV08_12011	Uncharacterized protein. (475 aa)
	PV08_11148	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (295 aa)
	PV08_11153	Aspartyl aminopeptidase; Belongs to the peptidase M18 family. (507 aa)
	PV08_11370	Protein kinase domain-containing protein. (873 aa)
	PV08_11611	Uncharacterized protein. (91 aa)
	PV08_11641	Uncharacterized protein. (323 aa)
	PV08_10016	Uncharacterized protein. (300 aa)
	PV08_10492	Uncharacterized protein. (334 aa)
	PV08_09417	Uncharacterized protein. (787 aa)
	PV08_07969	Uncharacterized protein. (435 aa)
	PV08_08009	Cupin_2 domain-containing protein. (136 aa)
	PV08_08099	Uncharacterized protein. (412 aa)
	PV08_08705	Uncharacterized protein. (401 aa)
	PV08_07034	Zn(2)-C6 fungal-type domain-containing protein. (556 aa)
	PV08_07829	Cupin_2 domain-containing protein. (204 aa)
	PV08_05548	Uncharacterized protein. (371 aa)
	PV08_06248	Uncharacterized protein. (385 aa)
	PV08_06318	Cupin_2 domain-containing protein. (137 aa)
	PV08_06552	Uncharacterized protein. (435 aa)
	PV08_04258	Uncharacterized protein. (521 aa)
	PV08_02430	Uncharacterized protein. (628 aa)
	PV08_00687	Uncharacterized protein. (853 aa)
	PV08_01002	Uncharacterized protein. (381 aa)
	PV08_11883	TPT domain-containing protein. (401 aa)
	PV08_11694	Uncharacterized protein. (749 aa)
	PV08_11484	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (345 aa)
	PV08_10615	AMP_N domain-containing protein. (449 aa)
	PV08_09403	Uncharacterized protein. (506 aa)
	PV08_09720	Uncharacterized protein. (585 aa)
	PV08_09946	Uncharacterized protein. (381 aa)
	PV08_09963	H_lectin domain-containing protein. (323 aa)
	PV08_08132	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
	PV08_06821	Uncharacterized protein. (146 aa)
	PV08_06826	Uncharacterized protein. (501 aa)
	PV08_07389	Uncharacterized protein. (311 aa)
	PV08_05923	Uncharacterized protein. (70 aa)
	PV08_05958	Uncharacterized protein. (540 aa)
	PV08_05760	Aminotran_1_2 domain-containing protein. (422 aa)
	PV08_06134	Uncharacterized protein. (480 aa)
	PV08_05840	TPT domain-containing protein. (507 aa)
	PV08_03821	GDP-mannose transporter 1. (389 aa)
	PV08_06361	AMP_N domain-containing protein. (496 aa)
	PV08_04364	Peptidase_M3 domain-containing protein. (723 aa)
	PV08_04211	Uncharacterized protein. (478 aa)
	PV08_04246	TPT domain-containing protein. (349 aa)
	PV08_04928	Uncharacterized protein. (343 aa)
	PV08_04988	Uncharacterized protein. (453 aa)
	PV08_05128	Uncharacterized protein. (454 aa)
	PV08_04875	Aldo_ket_red domain-containing protein. (336 aa)
	PV08_02411	Uncharacterized protein. (298 aa)
	PV08_05155	Uncharacterized protein. (336 aa)
	PV08_03430	Uncharacterized protein. (329 aa)
	PV08_03690	Uncharacterized protein. (762 aa)
	PV08_00042	Uncharacterized protein. (503 aa)
	PV08_00178	Peptidase_S9 domain-containing protein. (731 aa)
	PV08_09962	Uncharacterized protein. (102 aa)
	PV08_07961	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (321 aa)
	PV08_08006	2,3-dihydroxybenzoate decarboxylase; Belongs to the metallo-dependent hydrolases superfamily. (334 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (477 aa)
	PV08_01378	Uncharacterized protein. (476 aa)
	PV08_08825	RWD domain-containing protein. (358 aa)
	PV08_01654	Cupin_2 domain-containing protein. (130 aa)
	PV08_07619	Uncharacterized protein; Belongs to the peptidase S9B family. (909 aa)
	PV08_07776	PS_pyruv_trans domain-containing protein. (383 aa)
	PV08_07806	TPT domain-containing protein. (346 aa)
	PV08_06155	Mitochondrial intermediate peptidase. (793 aa)
	PV08_04114	Uncharacterized protein. (428 aa)
	PV08_04245	PS_pyruv_trans domain-containing protein. (388 aa)
	PV08_04250	Haloacid dehalogenase, type II. (275 aa)
	PV08_04260	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (333 aa)
	PV08_04753	Uncharacterized protein. (382 aa)
	PV08_04849	Uncharacterized protein. (547 aa)
	PV08_01049	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (326 aa)

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	A0A0D1YNY3	A0A0D2BP93	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.866
BNA1	BNA5	A0A0D1YNY3	A0A0D1YCU9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.908
BNA1	BNA5-2	A0A0D1YNY3	A0A0D1YWW9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.909
BNA1	PV08_00687	A0A0D1YNY3	A0A0D2A5R6	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.402
BNA1	PV08_01049	A0A0D1YNY3	A0A0D2CA91	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.761
BNA1	PV08_01650	A0A0D1YNY3	A0A0D1Z0G1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.591
BNA1	PV08_04260	A0A0D1YNY3	A0A0D2C0E0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.761
BNA1	PV08_07290	A0A0D1YNY3	A0A0D1YHZ4	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.591
BNA1	PV08_07961	A0A0D1YNY3	A0A0D2BNR9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.683
BNA1	PV08_08006	A0A0D1YNY3	A0A0D2BNX5	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	2,3-dihydroxybenzoate decarboxylase; Belongs to the metallo-dependent hydrolases superfamily.	0.591
BNA1	PV08_08132	A0A0D1YNY3	A0A0D2B2V7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.683
BNA1	PV08_09250	A0A0D1YNY3	A0A0D1YAM8	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.834
BNA1	PV08_10877	A0A0D1YNY3	A0A0D1Y9C5	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.683
BNA1	PV08_11484	A0A0D1YNY3	A0A0D2AVT8	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.683
BNA4	BNA1	A0A0D2BP93	A0A0D1YNY3	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.866
BNA4	BNA5	A0A0D2BP93	A0A0D1YCU9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.943
BNA4	BNA5-2	A0A0D2BP93	A0A0D1YWW9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.946
BNA4	PV08_00687	A0A0D2BP93	A0A0D2A5R6	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.834
BNA4	PV08_05760	A0A0D2BP93	A0A0D2BAT5	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.795
BNA4	PV08_08699	A0A0D2BP93	A0A0D1YEP2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.722