(36 nodes) Tryptophan catabolic process, and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase network (Exophiala spinifera)

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	PV08_12063	Uncharacterized protein. (469 aa)
	PV08_12044	Uncharacterized protein. (469 aa)
	PV08_10877	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (382 aa)
	PV08_09250	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (410 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (495 aa)
	PV08_08699	Aminotran_1_2 domain-containing protein. (630 aa)
	PV08_07290	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (338 aa)
	PV08_05211	Cupin_2 domain-containing protein. (152 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (184 aa)
	BNA5-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (465 aa)
	PV08_01650	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (235 aa)
	PV08_01675	Uncharacterized protein. (326 aa)
	PV08_12011	Uncharacterized protein. (475 aa)
	PV08_11148	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (295 aa)
	PV08_11641	Uncharacterized protein. (323 aa)
	PV08_10016	Uncharacterized protein. (300 aa)
	PV08_10492	Uncharacterized protein. (334 aa)
	PV08_07969	Uncharacterized protein. (435 aa)
	PV08_08009	Cupin_2 domain-containing protein. (136 aa)
	PV08_07829	Cupin_2 domain-containing protein. (204 aa)
	PV08_06318	Cupin_2 domain-containing protein. (137 aa)
	PV08_00687	Uncharacterized protein. (853 aa)
	PV08_11484	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (345 aa)
	PV08_08132	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (336 aa)
	PV08_06821	Uncharacterized protein. (146 aa)
	PV08_06826	Uncharacterized protein. (501 aa)
	PV08_05760	Aminotran_1_2 domain-containing protein. (422 aa)
	PV08_02411	Uncharacterized protein. (298 aa)
	PV08_07961	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (321 aa)
	PV08_08006	2,3-dihydroxybenzoate decarboxylase; Belongs to the metallo-dependent hydrolases superfamily. (334 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (477 aa)
	PV08_08825	RWD domain-containing protein. (358 aa)
	PV08_01654	Cupin_2 domain-containing protein. (130 aa)
	PV08_04114	Uncharacterized protein. (428 aa)
	PV08_04260	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (333 aa)
	PV08_01049	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. (326 aa)

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	A0A0D1YNY3	A0A0D2BP93	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.866
BNA1	BNA5	A0A0D1YNY3	A0A0D1YCU9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.908
BNA1	BNA5-2	A0A0D1YNY3	A0A0D1YWW9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.909
BNA1	PV08_00687	A0A0D1YNY3	A0A0D2A5R6	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Uncharacterized protein.	0.402
BNA1	PV08_01049	A0A0D1YNY3	A0A0D2CA91	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.761
BNA1	PV08_01650	A0A0D1YNY3	A0A0D1Z0G1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.591
BNA1	PV08_04260	A0A0D1YNY3	A0A0D2C0E0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.761
BNA1	PV08_07290	A0A0D1YNY3	A0A0D1YHZ4	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.591
BNA1	PV08_07961	A0A0D1YNY3	A0A0D2BNR9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.683
BNA1	PV08_08006	A0A0D1YNY3	A0A0D2BNX5	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	2,3-dihydroxybenzoate decarboxylase; Belongs to the metallo-dependent hydrolases superfamily.	0.591
BNA1	PV08_08132	A0A0D1YNY3	A0A0D2B2V7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.683
BNA1	PV08_09250	A0A0D1YNY3	A0A0D1YAM8	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.834
BNA1	PV08_10877	A0A0D1YNY3	A0A0D1Y9C5	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.683
BNA1	PV08_11484	A0A0D1YNY3	A0A0D2AVT8	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Amidohydro-rel domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily.	0.683
BNA4	BNA1	A0A0D2BP93	A0A0D1YNY3	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.866
BNA4	BNA5	A0A0D2BP93	A0A0D1YCU9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.943
BNA4	BNA5-2	A0A0D2BP93	A0A0D1YWW9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.946
BNA4	PV08_00687	A0A0D2BP93	A0A0D2A5R6	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.834
BNA4	PV08_05760	A0A0D2BP93	A0A0D2BAT5	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.795
BNA4	PV08_08699	A0A0D2BP93	A0A0D1YEP2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.722