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TAH18 TAH18 PV08_02512 PV08_02512 PV08_01500 PV08_01500 CFD1 CFD1 PV08_06689 PV08_06689 CIA1 CIA1 PV08_10279 PV08_10279 PV08_01471 PV08_01471 PV08_00231 PV08_00231 PV08_05720 PV08_05720 PV08_07270 PV08_07270 PV08_01473 PV08_01473 PV08_02229 PV08_02229 PV08_07359 PV08_07359 PV08_01094 PV08_01094 PV08_08424 PV08_08424 NBP35 NBP35 PV08_00690 PV08_00690 PV08_00385 PV08_00385 PV08_09253 PV08_09253 PV08_02683 PV08_02683 DRE2 DRE2 PV08_04100 PV08_04100 PV08_03945 PV08_03945 PV08_03006 PV08_03006 PV08_02349 PV08_02349 PV08_07719 PV08_07719
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TAH18NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (645 aa)
PV08_02512Iron donor protein CyaY. (244 aa)
PV08_01500Uncharacterized protein. (1050 aa)
CFD1Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (336 aa)
PV08_06689Cysteine desulfurase, mitochondrial. (509 aa)
CIA1Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. (558 aa)
PV08_10279Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (203 aa)
PV08_01471Uncharacterized protein. (267 aa)
PV08_00231Fungal_trans domain-containing protein. (713 aa)
PV08_05720Haloacid dehalogenase, type II. (241 aa)
PV08_07270Fe-S_biosyn domain-containing protein. (249 aa)
PV08_01473Nfu_N domain-containing protein. (312 aa)
PV08_02229Haloacid dehalogenase, type II. (234 aa)
PV08_07359Uncharacterized protein. (316 aa)
PV08_01094Zn(2)-C6 fungal-type domain-containing protein. (802 aa)
PV08_08424Uncharacterized protein; Belongs to the complex I LYR family. (133 aa)
NBP35Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (342 aa)
PV08_00690Fungal_trans domain-containing protein. (587 aa)
PV08_00385Fe-S_biosyn domain-containing protein. (213 aa)
PV08_09253GCV_T domain-containing protein. (403 aa)
PV08_02683Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family. (593 aa)
DRE2Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...] (328 aa)
PV08_04100Uncharacterized protein. (427 aa)
PV08_03945FeS_assembly_P domain-containing protein. (200 aa)
PV08_03006Fe-S protein assembly co-chaperone HscB. (276 aa)
PV08_023492Fe-2S ferredoxin-type domain-containing protein. (210 aa)
PV08_07719Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (139 aa)
Your Current Organism:
Exophiala spinifera
NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera
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