72 items (Exophiala spinifera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV08_03368	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (502 aa)
	PV08_02338	Glutamine amidotransferase type-2 domain-containing protein. (2150 aa)
	PV08_04620	Uncharacterized protein. (311 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (184 aa)
	PV08_03844	Uncharacterized protein. (241 aa)
	PV08_05971	Malate dehydrogenase. (341 aa)
	PV08_09731	Fumarate hydratase, class II. (468 aa)
	PV08_00309	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (493 aa)
	PV08_00418	Dihydropteroate synthase. (472 aa)
	PV08_03335	Amidase domain-containing protein. (594 aa)
	PV08_02917	Chorismate synthase. (422 aa)
	PV08_11543	Dihydroneopterin aldolase. (257 aa)
	PV08_04627	Shikimate_dh_N domain-containing protein. (309 aa)
	PV08_06036	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
	PV08_05638	Uncharacterized protein. (148 aa)
	PV08_07675	NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (1080 aa)
	PV08_07588	Aspartate aminotransferase. (432 aa)
	PV08_07274	Aspartate aminotransferase. (440 aa)
	PV08_06996	Oxoglutarate dehydrogenase (Succinyl-transferring), E1 component. (1050 aa)
	PV08_08762	DHQ_synthase domain-containing protein. (508 aa)
	PV08_08468	Mur_ligase_M domain-containing protein. (489 aa)
	PV08_08536	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (503 aa)
	PV08_08460	Uncharacterized protein. (138 aa)
	PV08_09760	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (516 aa)
	PV08_09700	Phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (510 aa)
	PV08_09585	Uncharacterized protein. (203 aa)
	PV08_10309	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa)
	PV08_10623	Shikimate_dh_N domain-containing protein. (307 aa)
	PV08_10052	CN hydrolase domain-containing protein. (341 aa)
	PV08_11230	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (476 aa)
	PV08_11684	CN hydrolase domain-containing protein. (301 aa)
	PV08_02107	Glutaminase A. (465 aa)
	PV08_01727	Aspartate-semialdehyde dehydrogenase. (359 aa)
	PV08_03429	Succinate-semialdehyde dehydrogenase. (503 aa)
	PV08_03327	CN hydrolase domain-containing protein. (301 aa)
	PV08_02590	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (314 aa)
	PV08_02400	CN hydrolase domain-containing protein. (484 aa)
	PV08_02299	Aldedh domain-containing protein. (498 aa)
	PV08_04626	Uncharacterized protein. (824 aa)
	PV08_06338	Fungal_trans domain-containing protein. (534 aa)
	PV08_06308	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (483 aa)
	PV08_07799	M20_dimer domain-containing protein. (431 aa)
	PV08_08109	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (553 aa)
	PV08_10697	3-carboxy-cis,cis-muconate cycloisomerase. (450 aa)
	PV08_10627	Shikimate-5-dehydrogenase. (533 aa)
	PV08_10096	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (424 aa)
	PV08_02196	Uncharacterized protein. (445 aa)
	PV08_01026	Malic enzyme. (623 aa)
	PV08_00886	Malic enzyme. (592 aa)
	BNA5-2	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (465 aa)
	PV08_00128	Uncharacterized protein. (95 aa)
	PV08_02704	Shikimate_dh_N domain-containing protein. (238 aa)
	PV08_07255	3-dehydroquinate dehydratase, type I. (820 aa)
	PV08_07250	SnoaL-like domain-containing protein. (240 aa)
	PV08_07998	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (457 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (495 aa)
	PV08_10436	Glutamate decarboxylase; Belongs to the group II decarboxylase family. (521 aa)
	PV08_00147	Aspartate aminotransferase. (419 aa)
	PV08_02953	Chorismate mutase. (276 aa)
	PV08_02477	GTP cyclohydrolase I. (265 aa)
	PV08_05054	Succinate-semialdehyde dehydrogenase. (536 aa)
	PV08_04673	Ornithine aminotransferase. (485 aa)
	PV08_04445	Malate dehydrogenase. (352 aa)
	PV08_05939	Aldedh domain-containing protein. (492 aa)
	PV08_05485	Uncharacterized protein. (246 aa)
	PV08_05369	Aldedh domain-containing protein. (510 aa)
	PV08_07258	Shikimate_dh_N domain-containing protein. (305 aa)
	PV08_01381	Fe-ADH domain-containing protein. (360 aa)
	PV08_00930	Glutamine amidotransferase type-1 domain-containing protein. (885 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (477 aa)
	PV08_09801	3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the 2nd section; belongs to the EPSP synthase family. In the 4th section; belongs to the type-I 3-dehydroquinase family. In the N-terminal section; belongs to the dehydroquinate synthase family. (1600 aa)
	PV08_00888	3-carboxy-cis,cis-muconate cycloisomerase. (468 aa)

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	A0A0D1YNY3	A0A0D2BP93	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.866
BNA1	BNA5	A0A0D1YNY3	A0A0D1YCU9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.908
BNA1	BNA5-2	A0A0D1YNY3	A0A0D1YWW9	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.909
BNA1	PV08_02590	A0A0D1YNY3	A0A0D1ZZZ1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.633
BNA4	BNA1	A0A0D2BP93	A0A0D1YNY3	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.866
BNA4	BNA5	A0A0D2BP93	A0A0D1YCU9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.943
BNA4	BNA5-2	A0A0D2BP93	A0A0D1YWW9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.946
BNA4	PV08_02590	A0A0D2BP93	A0A0D1ZZZ1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.483
BNA5	BNA1	A0A0D1YCU9	A0A0D1YNY3	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.908
BNA5	BNA4	A0A0D1YCU9	A0A0D2BP93	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.943
BNA5	PV08_02590	A0A0D1YCU9	A0A0D1ZZZ1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.466
BNA5-2	BNA1	A0A0D1YWW9	A0A0D1YNY3	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.909
BNA5-2	BNA4	A0A0D1YWW9	A0A0D2BP93	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.946
BNA5-2	PV08_02590	A0A0D1YWW9	A0A0D1ZZZ1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.	0.466
PV08_00128	PV08_00309	A0A0D1YWB7	A0A0D2BMA9	Uncharacterized protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.423
PV08_00128	PV08_02299	A0A0D1YWB7	A0A0D1ZZC8	Uncharacterized protein.	Aldedh domain-containing protein.	0.423
PV08_00128	PV08_03429	A0A0D1YWB7	A0A0D2A2H1	Uncharacterized protein.	Succinate-semialdehyde dehydrogenase.	0.423
PV08_00128	PV08_05054	A0A0D1YWB7	A0A0D2C2J6	Uncharacterized protein.	Succinate-semialdehyde dehydrogenase.	0.423
PV08_00128	PV08_05369	A0A0D1YWB7	A0A0D2BVL1	Uncharacterized protein.	Aldedh domain-containing protein.	0.423
PV08_00128	PV08_05939	A0A0D1YWB7	A0A0D2BX62	Uncharacterized protein.	Aldedh domain-containing protein.	0.423