67 items (Exophiala spinifera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV08_03931	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (150 aa)
	PV08_04233	Uncharacterized protein. (531 aa)
	PV08_02475	Uncharacterized protein. (272 aa)
	PV08_02936	Phosphatidylinositol 3-kinase VPS34. (940 aa)
	PV08_03642	DJ-1_PfpI domain-containing protein. (252 aa)
	PV08_11205	Uncharacterized protein. (361 aa)
	PV08_11376	BZIP domain-containing protein. (465 aa)
	PV08_11378	Zn(2)-C6 fungal-type domain-containing protein. (745 aa)
	PV08_10072	Fungal_trans domain-containing protein. (549 aa)
	PV08_10555	Uncharacterized protein. (803 aa)
	PV08_10630	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (980 aa)
	PV08_10750	C3H1-type domain-containing protein. (435 aa)
	PV08_10785	Non-specific serine/threonine protein kinase. (916 aa)
	PV08_10932	Uncharacterized protein; Involved in DNA replication and cell separation. Belongs to the SDS23 family. (536 aa)
	PV08_08355	Uncharacterized protein. (1663 aa)
	PV08_08460	Uncharacterized protein. (138 aa)
	PV08_08503	Uncharacterized protein. (269 aa)
	PV08_07369	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (730 aa)
	PV08_05258	Magnesium-dependent phosphatase-1. (267 aa)
	PV08_05656	AMPK1_CBM domain-containing protein. (231 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (634 aa)
	PV08_04073	Uncharacterized protein. (221 aa)
	PV08_03975	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
	PV08_04775	Protein kinase domain-containing protein. (882 aa)
	PV08_10419	Uncharacterized protein. (219 aa)
	PV08_09172	Uncharacterized protein. (412 aa)
	PV08_09268	ATG16 domain-containing protein. (229 aa)
	PV08_09791	ATG11 domain-containing protein. (1411 aa)
	PV08_00958	Uncharacterized protein. (615 aa)
	PV08_08101	Non-specific serine/threonine protein kinase. (972 aa)
	PV08_01371	Autophagy_act_C domain-containing protein. (203 aa)
	PV08_08176	Zn(2)-C6 fungal-type domain-containing protein. (738 aa)
	PV08_04124	Uncharacterized protein. (393 aa)
	PV08_00223	Polyubiquitin. (305 aa)
	PV08_02129	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2916 aa)
	PV08_01928	Ubiquitin-like domain-containing protein. (592 aa)
	PV08_02168	Uncharacterized protein. (638 aa)
	PV08_02165	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (934 aa)
	PV08_03882	Autophagy-related protein 3. (372 aa)
	PV08_08612	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (274 aa)
	PV08_11379	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (437 aa)
	PV08_10215	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (508 aa)
	PV08_10350	Ubiquitin-40S ribosomal protein S27a. (154 aa)
	PV08_08308	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the complex I LYR family. (495 aa)
	PV08_07194	Uncharacterized protein. (172 aa)
	PV08_07495	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily. (918 aa)
	PV08_05589	AMPKBI domain-containing protein. (472 aa)
	PV08_05766	Uncharacterized protein. (244 aa)
	PV08_05961	Uncharacterized protein. (154 aa)
	PV08_06057	Myotubularin phosphatase domain-containing protein. (931 aa)
	PV08_04720	Protein kinase domain-containing protein. (983 aa)
	PV08_02509	DJ-1_PfpI domain-containing protein. (286 aa)
	PV08_03160	Uncharacterized protein. (440 aa)
	PV08_00676	TPR_REGION domain-containing protein. (644 aa)
	PV08_01298	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. (314 aa)
	PV08_01530	Uncharacterized protein. (150 aa)
	PV08_02086	Uncharacterized protein. (507 aa)
	PV08_02166	Uncharacterized protein. (220 aa)
	PV08_11903	Uncharacterized protein. (213 aa)
	PV08_11743	Zn(2)-C6 fungal-type domain-containing protein. (710 aa)
	PV08_10717	Uncharacterized protein. (221 aa)
	PV08_10792	Uncharacterized protein. (621 aa)
	PV08_10853	AMPK1_CBM domain-containing protein. (472 aa)
	PV08_09095	Uncharacterized protein. (171 aa)
	PV08_09130	Uncharacterized protein. (225 aa)
	PV08_05568	Autophagy-related protein. (115 aa)
	PV08_06273	Ubiquitin-like protein ATG12. (202 aa)

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MDM34	PV08_02165	A0A0D2BA20	A0A0D2BT53	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.605
MDM34	PV08_08176	A0A0D2BA20	A0A0D2BPI7	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Zn(2)-C6 fungal-type domain-containing protein.	0.863
MDM34	PV08_08612	A0A0D2BA20	A0A0D2BQL6	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.863
MDM34	PV08_09095	A0A0D2BA20	A0A0D1ZFP8	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Uncharacterized protein.	0.486
MDM34	PV08_11378	A0A0D2BA20	A0A0D2AVD9	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Zn(2)-C6 fungal-type domain-containing protein.	0.863
MDM34	PV08_11379	A0A0D2BA20	A0A0D1Y6A9	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.863
MDM34	PV08_11743	A0A0D2BA20	A0A0D1ZAE9	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	Zn(2)-C6 fungal-type domain-containing protein.	0.863
PV08_00223	PV08_00676	A0A0D2C7U5	A0A0D1YXV2	Polyubiquitin.	TPR_REGION domain-containing protein.	0.794
PV08_00223	PV08_01928	A0A0D2C7U5	A0A0D2BQS0	Polyubiquitin.	Ubiquitin-like domain-containing protein.	0.835
PV08_00223	PV08_02129	A0A0D2C7U5	A0A0D2CDF7	Polyubiquitin.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.659
PV08_00223	PV08_02165	A0A0D2C7U5	A0A0D2BT53	Polyubiquitin.	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.742
PV08_00223	PV08_02166	A0A0D2C7U5	A0A0D1Z1R0	Polyubiquitin.	Uncharacterized protein.	0.697
PV08_00223	PV08_02475	A0A0D2C7U5	A0A0D1ZZN5	Polyubiquitin.	Uncharacterized protein.	0.585
PV08_00223	PV08_02509	A0A0D2C7U5	A0A0D1YSI5	Polyubiquitin.	DJ-1_PfpI domain-containing protein.	0.585
PV08_00223	PV08_03642	A0A0D2C7U5	A0A0D2A358	Polyubiquitin.	DJ-1_PfpI domain-containing protein.	0.585
PV08_00223	PV08_03931	A0A0D2C7U5	A0A0D1ZVJ5	Polyubiquitin.	Ubiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family.	0.994
PV08_00223	PV08_05568	A0A0D2C7U5	A0A0D1ZRY6	Polyubiquitin.	Autophagy-related protein.	0.737
PV08_00223	PV08_05766	A0A0D2C7U5	A0A0D1YL02	Polyubiquitin.	Uncharacterized protein.	0.693
PV08_00223	PV08_07369	A0A0D2C7U5	A0A0D2B7E6	Polyubiquitin.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]	0.794
PV08_00223	PV08_08308	A0A0D2C7U5	A0A0D1YDM9	Polyubiquitin.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the complex I LYR family.	0.987