(89 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Exophiala spinifera)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	PV08_10330	AB hydrolase-1 domain-containing protein. (315 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (267 aa)
	PV08_09023	4HBT domain-containing protein. (173 aa)
	PV08_08013	Uncharacterized protein. (633 aa)
	PV08_08218	AMP-binding domain-containing protein. (328 aa)
	PV08_08479	Uncharacterized protein. (683 aa)
	PAD1	Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (268 aa)
	PV08_08699	Aminotran_1_2 domain-containing protein. (630 aa)
	PV08_08749	FAD_binding_3 domain-containing protein. (406 aa)
	PV08_07888	Flavodoxin_2 domain-containing protein. (266 aa)
	PAD1-2	Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (271 aa)
	PV08_03874	FAD_binding_3 domain-containing protein. (611 aa)
	PV08_02654	Uncharacterized protein. (578 aa)
	PV08_02859	Uncharacterized protein. (203 aa)
	PV08_00376	Uncharacterized protein. (564 aa)
	PV08_01056	FAD_binding_3 domain-containing protein. (546 aa)
	PV08_09664	Uncharacterized protein. (581 aa)
	PV08_08219	Uncharacterized protein. (131 aa)
	PV08_08480	Uncharacterized protein. (559 aa)
	PV08_07251	AP_endonuc_2 domain-containing protein. (339 aa)
	FDC1	Ferulic acid decarboxylase 1; Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites; Belongs to the UbiD family. UbiD-like/FDC subfamily. (532 aa)
	PV08_06188	4HBT domain-containing protein. (154 aa)
	PV08_04158	Uncharacterized protein. (568 aa)
	PV08_04408	Fungal_trans domain-containing protein. (555 aa)
	PV08_04448	AB hydrolase-1 domain-containing protein. (334 aa)
	PV08_04631	AP_endonuc_2 domain-containing protein. (363 aa)
	PV08_02715	AP_endonuc_2 domain-containing protein. (396 aa)
	PV08_03677	FAD_binding_3 domain-containing protein. (602 aa)
	PV08_00109	Uncharacterized protein. (144 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (364 aa)
	PV08_01646	Uncharacterized protein. (556 aa)
	PV08_01937	Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (346 aa)
	PV08_02102	FAD_binding_3 domain-containing protein. (446 aa)
	PV08_11924	Uncharacterized protein. (176 aa)
	PV08_11449	FAD_binding_3 domain-containing protein. (575 aa)
	PV08_11569	Uncharacterized protein. (564 aa)
	PV08_11664	FAD_binding_3 domain-containing protein. (589 aa)
	PV08_10535	4HBT domain-containing protein. (151 aa)
	PV08_10915	Uncharacterized protein. (546 aa)
	PV08_09030	NAD(P)H:quinone oxidoreductase, type IV. (205 aa)
	PV08_08085	Uncharacterized protein. (573 aa)
	PV08_07967	FAD_binding_3 domain-containing protein. (599 aa)
	PV08_08415	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (359 aa)
	FDC1-2	Ferulic acid decarboxylase 1; Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites; Belongs to the UbiD family. UbiD-like/FDC subfamily. (511 aa)
	PV08_08748	Fungal_trans domain-containing protein. (648 aa)
	PV08_07442	Uncharacterized protein. (320 aa)
	COQ5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (303 aa)
	PV08_07655	FAD_binding_3 domain-containing protein. (465 aa)
	PV08_05228	NAD(P)H:quinone oxidoreductase, type IV. (194 aa)
	PV08_07882	FAD_binding_3 domain-containing protein. (714 aa)
	PV08_05651	Uncharacterized protein. (545 aa)
	PV08_06076	Uncharacterized protein. (546 aa)
	PV08_06116	Aminotran_1_2 domain-containing protein. (403 aa)
	PV08_04003	4-hydroxyphenylpyruvate dioxygenase. (418 aa)
	PV08_03878	Uncharacterized protein. (615 aa)
	PV08_03919	FAD_binding_3 domain-containing protein. (433 aa)
	PV08_12061	Uncharacterized protein. (551 aa)
	PV08_12042	Uncharacterized protein. (551 aa)
	PV08_12013	Uncharacterized protein. (551 aa)
	PV08_04196	Aminotran_1_2 domain-containing protein. (558 aa)
	PV08_11975	Fungal_trans domain-containing protein. (613 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (533 aa)
	PV08_11573	Uncharacterized protein. (573 aa)
	PV08_10128	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (275 aa)
	PV08_02711	Uncharacterized protein. (563 aa)
	PAD1-3	Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (245 aa)
	PV08_02881	Uncharacterized protein. (293 aa)
	PV08_02708	AP_endonuc_2 domain-containing protein. (350 aa)
	PV08_10604	Uncharacterized protein. (560 aa)
	PV08_10624	AP_endonuc_2 domain-containing protein. (335 aa)
	PV08_02858	Uncharacterized protein. (282 aa)
	PV08_03397	4HBT domain-containing protein. (174 aa)
	PV08_00110	Uncharacterized protein. (137 aa)
	PV08_00638	Uncharacterized protein. (264 aa)
	PV08_00375	Uncharacterized protein. (1108 aa)
	PV08_01058	Fungal_trans domain-containing protein. (675 aa)
	PV08_01063	FAD_binding_3 domain-containing protein. (434 aa)
	PV08_08810	Uncharacterized protein. (569 aa)
	PV08_02000	4HBT domain-containing protein. (171 aa)
	PV08_07634	FAD_binding_3 domain-containing protein. (618 aa)
	PV08_07736	3-dmu-9_3-mt domain-containing protein. (177 aa)
	PV08_05754	Uncharacterized protein. (145 aa)
	PV08_06120	FAD_binding_3 domain-containing protein. (438 aa)
	PV08_04415	Uncharacterized protein. (285 aa)
	PV08_04526	Uncharacterized protein. (579 aa)
	PV08_04613	Uncharacterized protein. (545 aa)
	PV08_02562	Methyltransf_25 domain-containing protein. (243 aa)
	PV08_00999	Uncharacterized protein. (563 aa)
	PV08_02264	FAD_binding_3 domain-containing protein. (407 aa)

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COQ3	COQ5	A0A0D2A474	A0A0D2B6X5	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.776
COQ3	COQ6	A0A0D2A474	A0A0D2BG28	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.959
COQ3	COQ7	A0A0D2A474	A0A0D1Y813	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	0.913
COQ3	PV08_01056	A0A0D2A474	A0A0D1YYY1	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_01058	A0A0D2A474	A0A0D2BNK4	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Fungal_trans domain-containing protein.	0.506
COQ3	PV08_01063	A0A0D2A474	A0A0D2BNL2	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_02102	A0A0D2A474	A0A0D2A9W4	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_02264	A0A0D2A474	A0A0D2CDQ7	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_02881	A0A0D2A474	A0A0D2BI19	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Uncharacterized protein.	0.506
COQ3	PV08_03677	A0A0D2A474	A0A0D2A3A8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_03874	A0A0D2A474	A0A0D1YNL1	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_03919	A0A0D2A474	A0A0D2BDM9	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_04408	A0A0D2A474	A0A0D1ZWZ0	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Fungal_trans domain-containing protein.	0.506
COQ3	PV08_05754	A0A0D2A474	A0A0D2BWN7	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Uncharacterized protein.	0.506
COQ3	PV08_06120	A0A0D2A474	A0A0D2BXS8	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_07442	A0A0D2A474	A0A0D2B6W5	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Uncharacterized protein.	0.506
COQ3	PV08_07634	A0A0D2A474	A0A0D2BU93	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_07655	A0A0D2A474	A0A0D2B864	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506
COQ3	PV08_07736	A0A0D2A474	A0A0D2BUP3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	3-dmu-9_3-mt domain-containing protein.	0.599
COQ3	PV08_07882	A0A0D2A474	A0A0D2B8W4	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	FAD_binding_3 domain-containing protein.	0.506