(33 nodes) Terpenoid backbone biosynthesis network (Exophiala spinifera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV08_06212	Uncharacterized protein. (425 aa)
	PV08_00360	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (469 aa)
	PV08_01035	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
	PV08_01677	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (468 aa)
	PV08_02078	Isopentenyl-diphosphate delta-isomerase. (298 aa)
	PV08_02286	Abhydrolase_3 domain-containing protein. (336 aa)
	PV08_09606	Uncharacterized protein. (359 aa)
	PV08_09581	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	PV08_03343	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1145 aa)
	PV08_02603	Uncharacterized protein. (268 aa)
	PV08_11648	AB hydrolase-1 domain-containing protein. (569 aa)
	PV08_02370	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (347 aa)
	PV08_11306	Uncharacterized protein. (573 aa)
	PV08_11110	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (239 aa)
	PV08_06517	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (295 aa)
	PV08_05783	Peptidase_M48 domain-containing protein. (348 aa)
	PV08_07727	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (855 aa)
	PV08_07307	Uncharacterized protein. (419 aa)
	PV08_08941	Uncharacterized protein. (467 aa)
	PV08_08626	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (386 aa)
	PV08_11982	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (398 aa)
	PV08_10832	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (459 aa)
	PV08_09245	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (469 aa)
	PV08_10792	Uncharacterized protein. (621 aa)
	PV08_09809	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (436 aa)
	PV08_07261	Di-trans,poly-cis-decaprenylcistransferase. (436 aa)
	PV08_02470	Uncharacterized protein. (328 aa)
	PV08_03369	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1008 aa)
	PV08_00281	Uncharacterized protein. (369 aa)
	PV08_01350	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (244 aa)
	PV08_11305	Uncharacterized protein. (845 aa)
	PV08_10410	Prenylcys_lyase domain-containing protein. (565 aa)
	PV08_09607	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (482 aa)

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV08_00281	PV08_00360	A0A0D2A4D4	A0A0D2BMH1	Uncharacterized protein.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.807
PV08_00281	PV08_02078	A0A0D2A4D4	A0A0D2BR75	Uncharacterized protein.	Isopentenyl-diphosphate delta-isomerase.	0.858
PV08_00281	PV08_02370	A0A0D2A4D4	A0A0D2BGH7	Uncharacterized protein.	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.807
PV08_00281	PV08_02603	A0A0D2A4D4	A0A0D2BI64	Uncharacterized protein.	Uncharacterized protein.	0.764
PV08_00281	PV08_03343	A0A0D2A4D4	A0A0D2BJI2	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.450
PV08_00281	PV08_07261	A0A0D2A4D4	A0A0D1ZNV8	Uncharacterized protein.	Di-trans,poly-cis-decaprenylcistransferase.	0.998
PV08_00281	PV08_08626	A0A0D2A4D4	A0A0D2B3H4	Uncharacterized protein.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.807
PV08_00281	PV08_09245	A0A0D2A4D4	A0A0D1YAM2	Uncharacterized protein.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.437
PV08_00281	PV08_09606	A0A0D2A4D4	A0A0D2BMB5	Uncharacterized protein.	Uncharacterized protein.	0.812
PV08_00281	PV08_09607	A0A0D2A4D4	A0A0D2B0V1	Uncharacterized protein.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.424
PV08_00281	PV08_10832	A0A0D2A4D4	A0A0D1Y998	Uncharacterized protein.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.810
PV08_00281	PV08_11982	A0A0D2A4D4	A0A0D1Y4L9	Uncharacterized protein.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.812
PV08_00360	PV08_00281	A0A0D2BMH1	A0A0D2A4D4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.807
PV08_00360	PV08_02078	A0A0D2BMH1	A0A0D2BR75	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Isopentenyl-diphosphate delta-isomerase.	0.803
PV08_00360	PV08_02370	A0A0D2BMH1	A0A0D2BGH7	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.863
PV08_00360	PV08_03343	A0A0D2BMH1	A0A0D2BJI2	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.534
PV08_00360	PV08_07261	A0A0D2BMH1	A0A0D1ZNV8	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Di-trans,poly-cis-decaprenylcistransferase.	0.830
PV08_00360	PV08_08626	A0A0D2BMH1	A0A0D2B3H4	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.834
PV08_00360	PV08_09245	A0A0D2BMH1	A0A0D1YAM2	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.577
PV08_00360	PV08_09606	A0A0D2BMH1	A0A0D2BMB5	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.796