55 items (Exophiala spinifera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PV08_02129	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2916 aa)
	PV08_01626	Uncharacterized protein. (111 aa)
	PV08_04892	FHA domain-containing protein. (854 aa)
	PV08_06173	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (608 aa)
	PV08_08818	RECA_2 domain-containing protein. (447 aa)
	PV08_08054	Uncharacterized protein. (308 aa)
	PV08_10010	Uncharacterized protein. (1018 aa)
	PV08_09190	Uncharacterized protein. (381 aa)
	PV08_11024	Uncharacterized protein. (939 aa)
	PV08_11329	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (349 aa)
	PV08_01600	DNA polymerase. (1107 aa)
	PV08_01364	Uncharacterized protein. (484 aa)
	PV08_03721	Uncharacterized protein. (265 aa)
	PV08_03275	Uncharacterized protein. (703 aa)
	PV08_05176	Uncharacterized protein. (308 aa)
	PV08_04352	Uncharacterized protein. (379 aa)
	PV08_03991	RECA_2 domain-containing protein. (483 aa)
	PV08_03724	Uncharacterized protein. (871 aa)
	PV08_05231	Uncharacterized protein. (533 aa)
	PV08_07315	HD domain-containing protein. (241 aa)
	PV08_07128	Smr domain-containing protein. (255 aa)
	PV08_08323	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (625 aa)
	PV08_08028	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (768 aa)
	PV08_07983	Uncharacterized protein. (151 aa)
	PV08_09008	CCHC-type domain-containing protein. (938 aa)
	PV08_10025	Uncharacterized protein. (186 aa)
	PV08_11137	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (505 aa)
	PV08_11902	PITH domain-containing protein. (226 aa)
	PV08_02267	Helicase ATP-binding domain-containing protein. (1253 aa)
	PV08_10289	Rad51 domain-containing protein. (519 aa)
	PV08_09216	Uncharacterized protein. (226 aa)
	PV08_09279	Uncharacterized protein. (876 aa)
	PV08_09450	Stn1 domain-containing protein. (344 aa)
	PV08_08985	HTH myb-type domain-containing protein. (556 aa)
	PV08_07322	Uncharacterized protein. (1513 aa)
	PV08_07187	Helicase C-terminal domain-containing protein. (764 aa)
	PV08_07239	Uncharacterized protein. (209 aa)
	PV08_05603	Uncharacterized protein. (165 aa)
	PV08_06286	Zds_C domain-containing protein. (916 aa)
	PV08_11884	Amino_oxidase domain-containing protein. (534 aa)
	PV08_04795	Uncharacterized protein. (510 aa)
	PV08_11513	Uncharacterized protein. (144 aa)
	PV08_11523	ERCC4 domain-containing protein. (615 aa)
	PV08_10840	Uncharacterized protein. (810 aa)
	PV08_03499	Uncharacterized protein. (1306 aa)
	PV08_09505	ERCC4 domain-containing protein. (659 aa)
	PV08_00968	Uncharacterized protein. (147 aa)
	PV08_10007	Uncharacterized protein. (134 aa)
	PV08_08001	Uncharacterized protein. (91 aa)
	PV08_02143	Uncharacterized protein. (581 aa)
	PV08_06523	Uncharacterized protein. (634 aa)
	PV08_00964	Uncharacterized protein. (1879 aa)
	PV08_01969	CCHC-type domain-containing protein. (393 aa)
	PV08_02039	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (174 aa)
	PV08_01972	Uncharacterized protein. (275 aa)

Your Current Organism:

Exophiala spinifera

NCBI taxonomy Id: 91928
Other names: ATCC 18218, CBS 899.68, DUKE 3342, E. spinifera, NCMH 152, NCPF 2358, Phialophora spinifera, Rhinocladiella spinifera

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV08_00964	PV08_02129	A0A0D2C9Z7	A0A0D2CDF7	Uncharacterized protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.582
PV08_00964	PV08_03991	A0A0D2C9Z7	A0A0D1YNU8	Uncharacterized protein.	RECA_2 domain-containing protein.	0.628
PV08_00964	PV08_04892	A0A0D2C9Z7	A0A0D1ZYG5	Uncharacterized protein.	FHA domain-containing protein.	0.519
PV08_00964	PV08_05231	A0A0D2C9Z7	A0A0D1YJM9	Uncharacterized protein.	Uncharacterized protein.	0.647
PV08_00964	PV08_06173	A0A0D2C9Z7	A0A0D1ZTL9	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.478
PV08_00964	PV08_07187	A0A0D2C9Z7	A0A0D2B6V1	Uncharacterized protein.	Helicase C-terminal domain-containing protein.	0.466
PV08_00964	PV08_08028	A0A0D2C9Z7	A0A0D1YD01	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.490
PV08_00964	PV08_08818	A0A0D2C9Z7	A0A0D1ZLD2	Uncharacterized protein.	RECA_2 domain-containing protein.	0.604
PV08_00964	PV08_10840	A0A0D2C9Z7	A0A0D2BJU5	Uncharacterized protein.	Uncharacterized protein.	0.759
PV08_00964	PV08_11024	A0A0D2C9Z7	A0A0D1ZFD4	Uncharacterized protein.	Uncharacterized protein.	0.763
PV08_00964	PV08_11137	A0A0D2C9Z7	A0A0D1Y5G6	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.483
PV08_00964	PV08_11329	A0A0D2C9Z7	A0A0D1ZBF2	Uncharacterized protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.876
PV08_00964	PV08_11523	A0A0D2C9Z7	A0A0D2BGV8	Uncharacterized protein.	ERCC4 domain-containing protein.	0.633
PV08_00968	PV08_01364	A0A0D2BN77	A0A0D1YZP0	Uncharacterized protein.	Uncharacterized protein.	0.427
PV08_00968	PV08_01972	A0A0D2BN77	A0A0D2A9E5	Uncharacterized protein.	Uncharacterized protein.	0.409
PV08_00968	PV08_02267	A0A0D2BN77	A0A0D2AA93	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.473
PV08_00968	PV08_03499	A0A0D2BN77	A0A0D2BKS6	Uncharacterized protein.	Uncharacterized protein.	0.480
PV08_00968	PV08_03724	A0A0D2BN77	A0A0D1YNA6	Uncharacterized protein.	Uncharacterized protein.	0.473
PV08_00968	PV08_03991	A0A0D2BN77	A0A0D1YNU8	Uncharacterized protein.	RECA_2 domain-containing protein.	0.410
PV08_00968	PV08_04352	A0A0D2BN77	A0A0D1YPM7	Uncharacterized protein.	Uncharacterized protein.	0.808