(44 nodes) Site of double-strand break network (Aptenodytes forsteri)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AS27_11412	Pre-mRNA-processing factor 19. (376 aa)
	AS27_11419	DNA damage-binding protein 1. (1124 aa)
	AS27_06002	Checkpoint protein HUS1. (266 aa)
	AS27_09370	Aprataxin and PNK-like factor. (379 aa)
	AS27_09382	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (378 aa)
	AS27_00412	Protein FAM35A. (671 aa)
	AS27_10693	E3 ubiquitin-protein ligase RNF169. (524 aa)
	AS27_14219	Double-strand break repair protein MRE11; Belongs to the MRE11/RAD32 family. (699 aa)
	AS27_07322	Histone-lysine N-methyltransferase SETMAR. (258 aa)
	AS27_07334	E3 ubiquitin-protein ligase RAD18. (360 aa)
	AS27_08179	Actin-related protein 3; Belongs to the actin family. (403 aa)
	AS27_15483	Uncharacterized protein. (256 aa)
	AS27_00564	Integrator complex subunit 3. (307 aa)
	AS27_03808	Telomere-associated protein RIF1. (2293 aa)
	AS27_15555	annotation not available (956 aa)
	AS27_06729	Non-homologous end-joining factor 1. (310 aa)
	AS27_06754	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (275 aa)
	AS27_04415	N-acetyltransferase ESCO2. (533 aa)
	AS27_09894	E3 UFM1-protein ligase 1. (600 aa)
	AS27_06828	Cyclic GMP-AMP synthase. (308 aa)
	AS27_02190	SOSS complex subunit B2. (99 aa)
	AS27_02698	DNA polymerase lambda. (151 aa)
	AS27_02710	Protein FAM178A. (572 aa)
	AS27_02711	Uncharacterized protein. (239 aa)
	AS27_05316	SOSS complex subunit C. (96 aa)
	AS27_07012	Meiotic recombination protein REC114-like. (248 aa)
	AS27_06349	NAD-dependent protein deacetylase sirtuin-7. (241 aa)
	AS27_10069	DNA helicase B. (876 aa)
	AS27_08567	NAD-dependent protein deacetylase sirtuin-6. (336 aa)
	AS27_00733	DNA repair protein XRCC4. (283 aa)
	AS27_12716	Uncharacterized protein C20orf196. (212 aa)
	AS27_09847	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1. (533 aa)
	AS27_11799	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
	AS27_08605	E3 ubiquitin-protein ligase RNF8. (136 aa)
	AS27_08606	E3 ubiquitin-protein ligase RNF8. (225 aa)
	AS27_08626	DNA polymerase eta. (535 aa)
	AS27_00842	Actin-related protein 2/3 complex subunit 3. (176 aa)
	AS27_05829	Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (209 aa)
	AS27_11671	Actin-related protein 2/3 complex subunit 4. (127 aa)
	AS27_13669	E3 ubiquitin-protein ligase RNF168. (573 aa)
	AS27_05888	DNA endonuclease RBBP8. (919 aa)
	AS27_12096	DNA repair protein RAD50. (1312 aa)
	AS27_12189	Replication protein A 14 kDa subunit. (82 aa)
	AS27_10275	Ankyrin repeat domain-containing protein 32. (420 aa)

Your Current Organism:

Aptenodytes forsteri

NCBI taxonomy Id: 9233
Other names: A. forsteri, emperor penguin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AS27_00412	AS27_12716	A0A087QH97	A0A087R8C8	Protein FAM35A.	Uncharacterized protein C20orf196.	0.626
AS27_00412	AS27_15483	A0A087QH97	A0A087QP32	Protein FAM35A.	Uncharacterized protein.	0.924
AS27_00564	AS27_02190	A0A087QP87	A0A087QXU1	Integrator complex subunit 3.	SOSS complex subunit B2.	0.962
AS27_00564	AS27_05316	A0A087QP87	A0A087R111	Integrator complex subunit 3.	SOSS complex subunit C.	0.991
AS27_00733	AS27_06729	A0A087R6G7	A0A087QTS0	DNA repair protein XRCC4.	Non-homologous end-joining factor 1.	0.732
AS27_00842	AS27_06754	A0A087RB28	A0A087QTU1	Actin-related protein 2/3 complex subunit 3.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.999
AS27_00842	AS27_08179	A0A087RB28	A0A087QNL7	Actin-related protein 2/3 complex subunit 3.	Actin-related protein 3; Belongs to the actin family.	0.985
AS27_00842	AS27_09382	A0A087RB28	A0A087QH73	Actin-related protein 2/3 complex subunit 3.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.998
AS27_00842	AS27_11671	A0A087RB28	A0A087RC40	Actin-related protein 2/3 complex subunit 3.	Actin-related protein 2/3 complex subunit 4.	0.999
AS27_02190	AS27_00564	A0A087QXU1	A0A087QP87	SOSS complex subunit B2.	Integrator complex subunit 3.	0.962
AS27_02190	AS27_05316	A0A087QXU1	A0A087R111	SOSS complex subunit B2.	SOSS complex subunit C.	0.904
AS27_02698	AS27_06729	A0A087QZA3	A0A087QTS0	DNA polymerase lambda.	Non-homologous end-joining factor 1.	0.662
AS27_02698	AS27_07012	A0A087QZA3	A0A087R1C1	DNA polymerase lambda.	Meiotic recombination protein REC114-like.	0.804
AS27_02698	AS27_07334	A0A087QZA3	A0A087QJE2	DNA polymerase lambda.	E3 ubiquitin-protein ligase RAD18.	0.469
AS27_02698	AS27_09370	A0A087QZA3	A0A087QH63	DNA polymerase lambda.	Aprataxin and PNK-like factor.	0.601
AS27_02698	AS27_12189	A0A087QZA3	A0A087RFR9	DNA polymerase lambda.	Replication protein A 14 kDa subunit.	0.609
AS27_02710	AS27_02711	A0A087QZB4	A0A087QZB5	Protein FAM178A.	Uncharacterized protein.	0.780
AS27_02711	AS27_02710	A0A087QZB5	A0A087QZB4	Uncharacterized protein.	Protein FAM178A.	0.780
AS27_03808	AS27_08605	A0A087QQ69	A0A087RAQ3	Telomere-associated protein RIF1.	E3 ubiquitin-protein ligase RNF8.	0.562
AS27_03808	AS27_08606	A0A087QQ69	A0A087RAQ4	Telomere-associated protein RIF1.	E3 ubiquitin-protein ligase RNF8.	0.562