(23 nodes) Regulation of intracellular steroid hormone receptor signaling pathway network (Pygoscelis adeliae)

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Your Input:
	PIAS2	E3 SUMO-protein ligase PIAS2. (614 aa)
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (881 aa)
	TCF21	Transcription factor 21. (150 aa)
	BRCA1	Breast cancer type 1 susceptibility protein. (1767 aa)
	AR	Androgen receptor. (382 aa)
	AS28_08398	Nuclear receptor corepressor 2. (699 aa)
	VPS18	Vacuolar protein sorting-associated protein 18. (951 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (663 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1574 aa)
	AS28_09798	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (511 aa)
	AS28_08033	25-hydroxycholesterol 7-alpha-hydroxylase. (477 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (524 aa)
	AS28_07109	DDRGK domain-containing protein 1. (291 aa)
	GHRHR	Growth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (405 aa)
	NCOR1	Nuclear receptor corepressor 1. (2473 aa)
	RNF14	RBR-type E3 ubiquitin transferase. (472 aa)
	RNF6	E3 ubiquitin-protein ligase RNF6. (653 aa)
	RQCD1	Cell differentiation protein RCD1. (296 aa)
	DYX1C1	Dyslexia susceptibility 1 candidate 1. (406 aa)
	CARM1	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (395 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1. (602 aa)
	LATS1	Serine/threonine-protein kinase LATS1. (1140 aa)
	DDX5	Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (592 aa)

Your Current Organism:

Pygoscelis adeliae

NCBI taxonomy Id: 9238
Other names: Adelie penguin, P. adeliae, Pygoscelis adelia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	AS28_08398	A0A093NKG2	A0A093NJG8	Androgen receptor.	Nuclear receptor corepressor 2.	0.769
AR	AS28_09798	A0A093NKG2	A0A093N7Q3	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.489
AR	BRCA1	A0A093NKG2	A0A093NMN7	Androgen receptor.	Breast cancer type 1 susceptibility protein.	0.479
AR	MED1	A0A093NKG2	A0A093N8W9	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.489
AR	NCOR1	A0A093NKG2	A0A093P7X7	Androgen receptor.	Nuclear receptor corepressor 1.	0.769
AR	PIAS2	A0A093NKG2	A0A093NQC1	Androgen receptor.	E3 SUMO-protein ligase PIAS2.	0.463
AR	RNF14	A0A093NKG2	A0A093P7C4	Androgen receptor.	RBR-type E3 ubiquitin transferase.	0.699
AS28_08398	AR	A0A093NJG8	A0A093NKG2	Nuclear receptor corepressor 2.	Androgen receptor.	0.769
AS28_08398	AS28_09798	A0A093NJG8	A0A093N7Q3	Nuclear receptor corepressor 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.465
AS28_08398	CARM1	A0A093NJG8	A0A093NYT0	Nuclear receptor corepressor 2.	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.558
AS28_08398	MED1	A0A093NJG8	A0A093N8W9	Nuclear receptor corepressor 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.465
AS28_08398	SIRT1	A0A093NJG8	A0A093NU82	Nuclear receptor corepressor 2.	NAD-dependent protein deacetylase sirtuin-1.	0.598
AS28_09798	AR	A0A093N7Q3	A0A093NKG2	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Androgen receptor.	0.489
AS28_09798	AS28_08398	A0A093N7Q3	A0A093NJG8	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor corepressor 2.	0.465
AS28_09798	NCOR1	A0A093N7Q3	A0A093P7X7	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Nuclear receptor corepressor 1.	0.465
BRCA1	AR	A0A093NMN7	A0A093NKG2	Breast cancer type 1 susceptibility protein.	Androgen receptor.	0.479
BRCA1	PIAS2	A0A093NMN7	A0A093NQC1	Breast cancer type 1 susceptibility protein.	E3 SUMO-protein ligase PIAS2.	0.469
CARM1	AS28_08398	A0A093NYT0	A0A093NJG8	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor corepressor 2.	0.558
CARM1	DDX5	A0A093NYT0	A0A093NRU0	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	0.465
CARM1	NCOR1	A0A093NYT0	A0A093P7X7	Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor corepressor 1.	0.558