STRINGSTRING
AS28_07108 AS28_07108 DRD4 DRD4 ADCY1 ADCY1 ATF4 ATF4 MAPK10 MAPK10 AS28_03264 AS28_03264 SP1 SP1 FSHR FSHR AS28_11295 AS28_11295 ARNTL ARNTL OPN4 OPN4 NOS2 NOS2 HTR7 HTR7 SIRT6 SIRT6 PRKAA2 PRKAA2 CRY2 CRY2 CIPC CIPC AS28_06698 AS28_06698 AS28_08398 AS28_08398 PTX3 PTX3 AS28_12869 AS28_12869 LGR4 LGR4 GPR176 GPR176 INHBA INHBA PPP1CC PPP1CC PSPC1 PSPC1 MYBBP1A MYBBP1A LHCGR LHCGR GRIN3A GRIN3A FBXL21 FBXL21 NR1D2 NR1D2 GAS2 GAS2 NR0B2 NR0B2 ENOX2 ENOX2 PPARA PPARA DDX5 DDX5 PGR PGR PPARGC1A PPARGC1A AS28_02994 AS28_02994 AS28_05711 AS28_05711 TOP1 TOP1 SFPQ SFPQ AS28_01863 AS28_01863 TNFAIP6 TNFAIP6 SGPL1 SGPL1 SIRT1 SIRT1 CDK1 CDK1 TYRO3 TYRO3 GPR157 GPR157 TARDBP TARDBP NGFR NGFR NFIL3 NFIL3 ATOH7 ATOH7 AS28_13762 AS28_13762 TRPM2 TRPM2 MTTP MTTP HOMER1 HOMER1 PPP1CB PPP1CB AS28_11437 AS28_11437 THRAP3 THRAP3 NAMPT NAMPT DHX9 DHX9 PPARG PPARG ATG7 ATG7 SETX SETX RORB RORB AHR AHR SCAPER SCAPER PML PML FZD4 FZD4 CCDC90B CCDC90B DTL DTL ADNP ADNP AS28_13210 AS28_13210 MTNR1A MTNR1A CSNK1D CSNK1D EREG EREG EGR1 EGR1 NCOR1 NCOR1 AS28_03580 AS28_03580 CCRN4L CCRN4L PROK2 PROK2 ARNTL2 ARNTL2 KDM5A KDM5A DNM1L DNM1L ID2 ID2 DRD2 DRD2 MC3R MC3R AS28_14883 AS28_14883 NRIP1 NRIP1 BTBD9 BTBD9 CRTC1 CRTC1 OGT OGT HDAC3 HDAC3 AS28_07291 AS28_07291 AS28_07342 AS28_07342 ZPBP2 ZPBP2 MAPK8 MAPK8 AS28_00335 AS28_00335 FSHB FSHB CLOCK CLOCK SLIT3 SLIT3 AS28_08256 AS28_08256 KDM8 KDM8 ENPP2 ENPP2 AS28_11597 AS28_11597 AS28_05930 AS28_05930 MAPK9 MAPK9 HLF HLF NDUFA9 NDUFA9 AS28_08743 AS28_08743 AS28_12474 AS28_12474 BMPR1B BMPR1B NFYA NFYA NUDT12 NUDT12 AS28_03193 AS28_03193 AANAT AANAT AS28_10489 AS28_10489 PRKAA1 PRKAA1 USP2 USP2 PROX1 PROX1 ZNF830 ZNF830 NONO NONO CSNK1E CSNK1E CRY1 CRY1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AS28_071085-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (369 aa)
DRD4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (287 aa)
ADCY1Adenylate cyclase type 1. (1090 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (355 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
AS28_03264Cyclic AMP-responsive element-binding protein 1. (351 aa)
SP1Transcription factor Sp1. (424 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (534 aa)
AS28_11295Cryptochrome-1. (527 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like 1. (626 aa)
OPN4Melanopsin. (312 aa)
NOS2Nitric oxide synthase, inducible. (1141 aa)
HTR75-hydroxytryptamine receptor 7. (247 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (337 aa)
PRKAA2Non-specific serine/threonine protein kinase. (521 aa)
CRY2Cryptochrome-2. (368 aa)
CIPCUncharacterized protein KIAA1737. (379 aa)
AS28_06698F-box/WD repeat-containing protein 7. (159 aa)
AS28_08398Nuclear receptor corepressor 2. (699 aa)
PTX3Pentraxin-related protein PTX3. (422 aa)
AS28_12869Aryl hydrocarbon receptor. (449 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (730 aa)
GPR176Putative G-protein coupled receptor 176. (478 aa)
INHBAInhibin beta A chain. (424 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (305 aa)
PSPC1Paraspeckle component 1. (258 aa)
MYBBP1AMyb-binding protein 1A-like. (1124 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (661 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (880 aa)
FBXL21F-box/LRR-repeat protein 3. (436 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (574 aa)
GAS2Growth arrest-specific protein 2. (314 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (194 aa)
ENOX2Ecto-NOX disulfide-thiol exchanger 2. (595 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (470 aa)
DDX5Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (592 aa)
PGRProgesterone receptor. (415 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (781 aa)
AS28_02994Period circadian protein 2. (1336 aa)
AS28_05711Slit 2 protein. (1142 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (747 aa)
SFPQSplicing factor, proline-and glutamine-rich. (418 aa)
AS28_01863ATP-dependent RNA helicase A. (367 aa)
TNFAIP6Tumor necrosis factor-inducible 6. (275 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (559 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (602 aa)
CDK1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (294 aa)
TYRO3Tyrosine-protein kinase receptor TYRO3. (843 aa)
GPR157Putative G-protein coupled receptor 157. (338 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (173 aa)
NFIL3Nuclear factor interleukin-3-regulated protein; May act as a transcriptional regulator of a number of proteins of the circadian clock; Belongs to the bZIP family. NFIL3 subfamily. (458 aa)
ATOH7Protein atonal 7. (151 aa)
AS28_13762Ecto-NOX disulfide-thiol exchanger 1. (539 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1513 aa)
MTTPMicrosomal triglyceride transfer protein large subunit. (873 aa)
HOMER1Homer protein 1. (363 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (312 aa)
AS28_11437UPF0524 protein C3orf70. (184 aa)
THRAP3Thyroid hormone receptor-associated protein 3. (976 aa)
NAMPTNicotinamide phosphoribosyltransferase. (473 aa)
DHX9ATP-dependent RNA helicase A. (823 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (483 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (701 aa)
SETXPutative helicase senataxin. (2540 aa)
RORBNuclear receptor ROR-beta. (462 aa)
AHRAryl hydrocarbon receptor. (844 aa)
SCAPERS phase cyclin A-associated protein in the endoplasmic reticulum. (1407 aa)
PMLProtein PML. (295 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (418 aa)
CCDC90BUncharacterized protein. (220 aa)
DTLDenticleless protein. (713 aa)
ADNPActivity-dependent neuroprotector homeobox protein. (1113 aa)
AS28_13210Melanopsin. (402 aa)
MTNR1AMelatonin receptor type 1A; Belongs to the G-protein coupled receptor 1 family. (289 aa)
CSNK1DCasein kinase I isoform delta. (385 aa)
EREGProepiregulin. (118 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (421 aa)
NCOR1Nuclear receptor corepressor 1. (2473 aa)
AS28_03580Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1400 aa)
CCRN4LNocturnin. (368 aa)
PROK2AVIToxin-VAR1. (77 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator-like 2. (364 aa)
KDM5ALysine-specific demethylase 5A. (1637 aa)
DNM1LDynamin-1-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (663 aa)
ID2DNA-binding protein inhibitor ID-2. (134 aa)
DRD2D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (457 aa)
MC3RMelanocortin receptor 3. (286 aa)
AS28_14883Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
NRIP1Nuclear receptor-interacting protein 1. (1162 aa)
BTBD9BTB/POZ domain-containing protein 9. (647 aa)
CRTC1CREB-regulated transcription coactivator 1. (576 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. (1023 aa)
HDAC3Histone deacetylase 3. (410 aa)
AS28_07291Nuclear receptor ROR-alpha. (468 aa)
AS28_07342Protein PML. (342 aa)
ZPBP2Zona pellucida-binding protein 2. (283 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AS28_00335Neuronal PAS domain-containing protein 2. (678 aa)
FSHBFollitropin subunit beta. (131 aa)
CLOCKCircadian locomoter output cycles protein kaput. (853 aa)
SLIT3Slit 3 protein. (1117 aa)
AS28_08256Lysine-specific demethylase 5B. (1555 aa)
KDM8Lysine-specific demethylase 8. (240 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2. (925 aa)
AS28_11597Tumor necrosis factor receptor superfamily member 16. (92 aa)
AS28_05930Nuclear factor NF-kappa-B p100 subunit. (657 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HLFHepatic leukemia factor. (248 aa)
NDUFA9Epimerase domain-containing protein. (361 aa)
AS28_08743Uncharacterized protein KIAA2013. (447 aa)
AS28_12474Tumor necrosis factor receptor superfamily member 11A. (257 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (454 aa)
NFYANuclear transcription factor Y subunit alpha. (348 aa)
NUDT12Peroxisomal NADH pyrophosphatase NUDT12. (464 aa)
AS28_03193Peptidyl-glycine alpha-amidating monooxygenase. (972 aa)
AANATSerotonin N-acetyltransferase. (205 aa)
AS28_10489Hepatocyte nuclear factor 1-beta. (415 aa)
PRKAA1Non-specific serine/threonine protein kinase. (517 aa)
USP2Ubiquitin carboxyl-terminal hydrolase 2; Belongs to the peptidase C19 family. (580 aa)
PROX1Prospero homeobox protein 1. (745 aa)
ZNF830Zinc finger protein 830. (286 aa)
NONONon-POU domain-containing octamer-binding protein. (462 aa)
CSNK1ECasein kinase I isoform epsilon. (393 aa)
CRY1Cryptochrome-1. (402 aa)
Your Current Organism:
Pygoscelis adeliae
NCBI taxonomy Id: 9238
Other names: Adelie penguin, P. adeliae, Pygoscelis adelia
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