91 items (Pygoscelis adeliae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SOX14	Transcription factor SOX-14. (234 aa)
	CTNNB1	Catenin beta-1. (668 aa)
	LRP5	Low-density lipoprotein receptor-related protein 5. (1545 aa)
	GSK3B	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily. (371 aa)
	CSNK2A2	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (315 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a. (141 aa)
	SOX9	Transcription factor Sox-9. (271 aa)
	SOX30	Transcription factor SOX-30. (517 aa)
	TRRAP	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3806 aa)
	LGR6	Leucine-rich repeat-containing G-protein coupled receptor 6. (840 aa)
	CDC73	Parafibromin. (487 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (730 aa)
	RBX1	RING-box protein 1. (78 aa)
	AS28_12568	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	SOST	Sclerostin. (198 aa)
	ZBTB44	Zinc finger and BTB domain-containing protein 44. (616 aa)
	SOX2	Transcription factor SOX-2. (315 aa)
	YWHAZ	14-3-3 protein zeta; Belongs to the 14-3-3 family. (229 aa)
	FZD6	Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (648 aa)
	RSPO2	R-spondin-2. (170 aa)
	PYGO1	Pygopus 1. (402 aa)
	AS28_13627	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (438 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1. (951 aa)
	XPO1	Exportin-1. (1076 aa)
	HMGXB3	HMG domain-containing protein 3. (1318 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (309 aa)
	AS28_12003	Tyrosine-protein kinase RYK. (478 aa)
	BCL9	B-cell CLL/lymphoma 9 protein. (1428 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (383 aa)
	BTRC	F-box/WD repeat-containing protein 1A. (593 aa)
	BCL9L	B-cell CLL/lymphoma 9-like. (612 aa)
	AS28_08259	Kelch-like 12. (417 aa)
	AS28_13795	Axin-2. (643 aa)
	LRP6	Low-density lipoprotein receptor-related protein 6. (1592 aa)
	DVL1	Segment polarity protein dishevelled DVL-1. (632 aa)
	AS28_09774	Transcription factor 7-like 2. (387 aa)
	KAT7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (610 aa)
	RNF146	E3 ubiquitin-protein ligase RNF146. (353 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	AS28_12610	Secreted frizzled-related protein 5. (294 aa)
	LGR5	Leucine-rich repeat-containing G-protein coupled receptor 5. (844 aa)
	RNF43	E3 ubiquitin-protein ligase RNF43. (750 aa)
	SMURF2	E3 ubiquitin-protein ligase SMURF2. (742 aa)
	AS28_14653	Lymphoid enhancer-binding factor 1. (315 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (116 aa)
	PIP5K1B	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta. (518 aa)
	RSPO1	R-spondin-1. (260 aa)
	SOX6	Transcription factor SOX-6. (789 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1103 aa)
	FZD4	Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (418 aa)
	AS28_13416	Putative methyltransferase. (269 aa)
	CTNNBIP1	Beta-catenin-interacting protein 1. (63 aa)
	TLE1	Transducin-like enhancer protein 1. (731 aa)
	SFRP1	Secreted frizzled-related protein 1. (276 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (313 aa)
	AS28_13075	C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (286 aa)
	AES	Amino-terminal enhancer of split. (188 aa)
	DKK1	Dickkopf-related protein 1. (96 aa)
	SOX11	Transcription factor SOX-11. (220 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (313 aa)
	PSMA7	Proteasome endopeptidase complex. (216 aa)
	SLC39A13	Zinc transporter ZIP13. (366 aa)
	DKK2	Dickkopf-related protein 2. (81 aa)
	AS28_14883	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (391 aa)
	WIF1	Wnt inhibitory factor 1. (283 aa)
	ZNRF3	E3 ubiquitin-protein ligase ZNRF3. (836 aa)
	DVL3	Segment polarity protein dishevelled DVL-3. (656 aa)
	UBB	Polyubiquitin. (290 aa)
	AS28_11470	Secreted frizzled-related protein 2. (278 aa)
	PSMA1	Proteasome endopeptidase complex. (246 aa)
	CBY1	Protein chibby 1. (100 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1250 aa)
	USP8	Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1085 aa)
	DACT1	Dapper 1. (700 aa)
	AS28_14128	Transcription factor SOX-3. (230 aa)
	AS28_05671	Transducin-like enhancer protein 1. (301 aa)
	AS28_09495	HMG domain-containing protein 4. (593 aa)
	SOX10	Transcription factor SOX-10. (457 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1100 aa)
	AKT1	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (465 aa)
	AS28_10141	Leucine-rich repeat and transmembrane domain-containing protein 1. (343 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (409 aa)
	SOX5	Transcription factor SOX-5. (761 aa)
	CSNK1E	Casein kinase I isoform epsilon. (393 aa)
	LEO1	RNA polymerase-associated protein LEO1. (637 aa)
	TLE4	Transducin-like enhancer protein 4. (728 aa)
	PSMD10	26S proteasome non-ATPase regulatory subunit 10. (155 aa)
	CUL3	Cullin-3; Belongs to the cullin family. (746 aa)
	AXIN1	Axin-1. (841 aa)
	AMER1	Uncharacterized protein. (125 aa)
	AS28_08201	Lymphoid enhancer-binding factor 1. (267 aa)

Your Current Organism:

Pygoscelis adeliae

NCBI taxonomy Id: 9238
Other names: Adelie penguin, P. adeliae, Pygoscelis adelia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AES	AS28_08201	A0A093P870	A0A093R5A5	Amino-terminal enhancer of split.	Lymphoid enhancer-binding factor 1.	0.613
AES	AS28_09774	A0A093P870	A0A093NUM7	Amino-terminal enhancer of split.	Transcription factor 7-like 2.	0.613
AES	AS28_13075	A0A093P870	A0A093P867	Amino-terminal enhancer of split.	C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.408
AES	AS28_14653	A0A093P870	A0A093NYJ8	Amino-terminal enhancer of split.	Lymphoid enhancer-binding factor 1.	0.613
AES	CTNNB1	A0A093P870	A0A093N7N4	Amino-terminal enhancer of split.	Catenin beta-1.	0.511
AES	PYGO1	A0A093P870	A0A093NPH5	Amino-terminal enhancer of split.	Pygopus 1.	0.497
AES	RPS27A	A0A093P870	A0A093NGN6	Amino-terminal enhancer of split.	Ubiquitin-40S ribosomal protein S27a.	0.406
AES	UBB	A0A093P870	A0A093PDK8	Amino-terminal enhancer of split.	Polyubiquitin.	0.403
AKT1	CTNNB1	A0A093QRY3	A0A093N7N4	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Catenin beta-1.	0.650
AKT1	GSK3B	A0A093QRY3	A0A093NBW5	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily.	0.963
AKT1	USP8	A0A093QRY3	A0A093PIH8	RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	Ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family.	0.542
AMER1	CTNNB1	A0A093R8D6	A0A093N7N4	Uncharacterized protein.	Catenin beta-1.	0.481
AMER1	GSK3B	A0A093R8D6	A0A093NBW5	Uncharacterized protein.	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily.	0.661
AMER1	RPS27A	A0A093R8D6	A0A093NGN6	Uncharacterized protein.	Ubiquitin-40S ribosomal protein S27a.	0.450
AS28_05671	AS28_08201	A0A093PKA9	A0A093R5A5	Transducin-like enhancer protein 1.	Lymphoid enhancer-binding factor 1.	0.613
AS28_05671	AS28_09774	A0A093PKA9	A0A093NUM7	Transducin-like enhancer protein 1.	Transcription factor 7-like 2.	0.613
AS28_05671	AS28_13075	A0A093PKA9	A0A093P867	Transducin-like enhancer protein 1.	C-terminal-binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.408
AS28_05671	AS28_14653	A0A093PKA9	A0A093NYJ8	Transducin-like enhancer protein 1.	Lymphoid enhancer-binding factor 1.	0.613
AS28_05671	CTNNB1	A0A093PKA9	A0A093N7N4	Transducin-like enhancer protein 1.	Catenin beta-1.	0.511
AS28_05671	PYGO1	A0A093PKA9	A0A093NPH5	Transducin-like enhancer protein 1.	Pygopus 1.	0.497