(12 nodes) Embryonic hindlimb morphogenesis network (Calypte anna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	N300_08948	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (319 aa)
	N300_15306	Protein odd-skipped-related 1. (249 aa)
	N300_03848	Protein fantom. (1265 aa)
	N300_05153	Pituitary homeobox 2. (257 aa)
	N300_01383	Zinc finger and BTB domain-containing protein 16. (670 aa)
	N300_14851	Uncharacterized protein. (167 aa)
	N300_08553	Homeobox protein GHOX-7. (177 aa)
	N300_13337	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (660 aa)
	N300_01502	Catenin beta-1. (777 aa)
	N300_11147	T-box transcription factor TBX2-B. (617 aa)
	N300_12501	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
	N300_06106	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1571 aa)

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_01502	N300_03848	A0A091HZ16	A0A091J4A4	Catenin beta-1.	Protein fantom.	0.456
N300_01502	N300_05153	A0A091HZ16	A0A091J0D4	Catenin beta-1.	Pituitary homeobox 2.	0.439
N300_01502	N300_08948	A0A091HZ16	A0A091HNJ8	Catenin beta-1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.760
N300_03848	N300_01502	A0A091J4A4	A0A091HZ16	Protein fantom.	Catenin beta-1.	0.456
N300_05153	N300_01502	A0A091J0D4	A0A091HZ16	Pituitary homeobox 2.	Catenin beta-1.	0.439
N300_08553	N300_12501	A0A091I579	A0A091HT20	Homeobox protein GHOX-7.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.414
N300_08553	N300_15306	A0A091I579	A0A091HJ51	Homeobox protein GHOX-7.	Protein odd-skipped-related 1.	0.414
N300_08948	N300_01502	A0A091HNJ8	A0A091HZ16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Catenin beta-1.	0.760
N300_08948	N300_12501	A0A091HNJ8	A0A091HT20	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.412
N300_12501	N300_08553	A0A091HT20	A0A091I579	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Homeobox protein GHOX-7.	0.414
N300_12501	N300_08948	A0A091HT20	A0A091HNJ8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.412
N300_12501	N300_15306	A0A091HT20	A0A091HJ51	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein odd-skipped-related 1.	0.434
N300_15306	N300_08553	A0A091HJ51	A0A091I579	Protein odd-skipped-related 1.	Homeobox protein GHOX-7.	0.414
N300_15306	N300_12501	A0A091HJ51	A0A091HT20	Protein odd-skipped-related 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.434