(30 nodes) ERBB signaling pathway network (Calypte anna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	N300_00679	Pro-neuregulin-3, membrane-bound isoform. (361 aa)
	N300_03278	Tyrosine-protein kinase. (418 aa)
	N300_15343	Disintegrin and metalloproteinase domain-containing protein 17. (797 aa)
	N300_15368	Receptor protein-tyrosine kinase. (1261 aa)
	N300_09473	Uncharacterized protein. (38 aa)
	N300_02081	Probetacellulin. (113 aa)
	N300_02922	Zinc transporter 10. (426 aa)
	N300_11037	Calcium signal-modulating cyclophilin ligand. (243 aa)
	N300_12553	Pro-neuregulin-4, membrane-bound isoform. (82 aa)
	N300_10435	Focal adhesion kinase 1. (1055 aa)
	N300_09310	Tyrosine-protein kinase. (1152 aa)
	N300_11359	Kinesin-like KIF16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1306 aa)
	N300_07488	Phosphoinositide phospholipase C. (613 aa)
	N300_14743	Receptor-type tyrosine-protein phosphatase R. (538 aa)
	N300_05150	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1181 aa)
	N300_02129	Amphiregulin. (146 aa)
	N300_12905	GRB2-associated and regulator of MAPK protein. (798 aa)
	N300_02128	Proepiregulin. (118 aa)
	N300_03577	Villin-1. (826 aa)
	N300_02127	Epigen. (151 aa)
	N300_08127	Proheparin-binding EGF-like growth factor. (135 aa)
	N300_10450	Protein-tyrosine kinase 2-beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (957 aa)
	N300_06111	Receptor protein-tyrosine kinase. (980 aa)
	N300_05377	Son of sevenless 1. (1289 aa)
	N300_08480	Protein FAM83A. (400 aa)
	N300_02660	Tyrosine-protein kinase. (1101 aa)
	N300_11971	Myocilin. (302 aa)
	N300_05040	Transcription factor Sox-9. (417 aa)
	N300_02293	Pro-neuregulin-1, membrane-bound isoform. (576 aa)
	N300_15066	Receptor protein-tyrosine kinase. (1118 aa)

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_00679	N300_06111	A0A091HRN2	A0A091HMI6	Pro-neuregulin-3, membrane-bound isoform.	Receptor protein-tyrosine kinase.	0.651
N300_00679	N300_12553	A0A091HRN2	A0A091INH5	Pro-neuregulin-3, membrane-bound isoform.	Pro-neuregulin-4, membrane-bound isoform.	0.856
N300_00679	N300_15066	A0A091HRN2	A0A091HUT6	Pro-neuregulin-3, membrane-bound isoform.	Receptor protein-tyrosine kinase.	0.651
N300_00679	N300_15368	A0A091HRN2	A0A091HM34	Pro-neuregulin-3, membrane-bound isoform.	Receptor protein-tyrosine kinase.	0.651
N300_02081	N300_02127	A0A091IVJ0	A0A091IVM6	Probetacellulin.	Epigen.	0.756
N300_02081	N300_02128	A0A091IVJ0	A0A091I634	Probetacellulin.	Proepiregulin.	0.752
N300_02081	N300_02129	A0A091IVJ0	A0A091I879	Probetacellulin.	Amphiregulin.	0.755
N300_02081	N300_02293	A0A091IVJ0	A0A091HXM9	Probetacellulin.	Pro-neuregulin-1, membrane-bound isoform.	0.573
N300_02081	N300_03278	A0A091IVJ0	A0A091HS58	Probetacellulin.	Tyrosine-protein kinase.	0.525
N300_02081	N300_05150	A0A091IVJ0	A0A091I9H8	Probetacellulin.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.764
N300_02081	N300_06111	A0A091IVJ0	A0A091HMI6	Probetacellulin.	Receptor protein-tyrosine kinase.	0.794
N300_02081	N300_08127	A0A091IVJ0	A0A091J361	Probetacellulin.	Proheparin-binding EGF-like growth factor.	0.760
N300_02081	N300_09473	A0A091IVJ0	A0A091HM50	Probetacellulin.	Uncharacterized protein.	0.693
N300_02081	N300_15066	A0A091IVJ0	A0A091HUT6	Probetacellulin.	Receptor protein-tyrosine kinase.	0.794
N300_02081	N300_15368	A0A091IVJ0	A0A091HM34	Probetacellulin.	Receptor protein-tyrosine kinase.	0.794
N300_02127	N300_02081	A0A091IVM6	A0A091IVJ0	Epigen.	Probetacellulin.	0.756
N300_02127	N300_02128	A0A091IVM6	A0A091I634	Epigen.	Proepiregulin.	0.782
N300_02127	N300_02129	A0A091IVM6	A0A091I879	Epigen.	Amphiregulin.	0.699
N300_02127	N300_05150	A0A091IVM6	A0A091I9H8	Epigen.	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.	0.753
N300_02127	N300_06111	A0A091IVM6	A0A091HMI6	Epigen.	Receptor protein-tyrosine kinase.	0.768