(24 nodes) Negative regulation of MAP kinase activity network (Calypte anna)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	N300_04254	Neurofibromin. (68 aa)
	N300_04398	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
	N300_11086	Protein sprouty 2. (313 aa)
	N300_04622	Programmed cell death protein 4. (454 aa)
	N300_14562	Inositol polyphosphate 5-phosphatase K. (449 aa)
	N300_10809	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1069 aa)
	N300_02395	Glucosylceramidase. (164 aa)
	N300_09618	Dual specificity protein phosphatase 10. (478 aa)
	N300_02393	Glucosylceramidase. (448 aa)
	N300_09622	Axin interactor, dorsalization-associated protein. (269 aa)
	N300_02134	Progestin and adipoQ receptor family member 3. (251 aa)
	N300_06496	Receptor-type tyrosine-protein phosphatase eta. (1059 aa)
	N300_14129	Tyrosine-protein phosphatase non-receptor type 6. (608 aa)
	N300_15402	Tyrosine-protein kinase. (513 aa)
	N300_13687	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (116 aa)
	N300_04253	Neurofibromin. (76 aa)
	N300_10426	Adiponectin. (238 aa)
	N300_11484	Angiotensinogen; Belongs to the serpin family. (457 aa)
	N300_04348	3-hydroxy-3-methylglutaryl coenzyme A reductase. (882 aa)
	N300_14058	Protein sprouty 1. (267 aa)
	N300_02394	Glucosylceramidase. (443 aa)
	N300_09862	Transmembrane protein 130. (407 aa)
	N300_15381	Dual specificity protein phosphatase 19. (140 aa)
	N300_06576	Homeodomain-interacting protein kinase 3. (1192 aa)

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_02134	N300_10426	A0A091I886	A0A091IFM5	Progestin and adipoQ receptor family member 3.	Adiponectin.	0.885
N300_02134	N300_15381	A0A091I886	A0A091HKW6	Progestin and adipoQ receptor family member 3.	Dual specificity protein phosphatase 19.	0.536
N300_04253	N300_04254	A0A091IFF6	A0A091J2P9	Neurofibromin.	Neurofibromin.	0.929
N300_04254	N300_04253	A0A091J2P9	A0A091IFF6	Neurofibromin.	Neurofibromin.	0.929
N300_04398	N300_13687	A0A091J4F6	A0A091IF12	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.878
N300_04398	N300_15402	A0A091J4F6	A0A091ID16	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tyrosine-protein kinase.	0.715
N300_06496	N300_10809	A0A091IAG4	A0A091HXK2	Receptor-type tyrosine-protein phosphatase eta.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.434
N300_06496	N300_15402	A0A091IAG4	A0A091ID16	Receptor-type tyrosine-protein phosphatase eta.	Tyrosine-protein kinase.	0.419
N300_09618	N300_10809	A0A091I4T0	A0A091HXK2	Dual specificity protein phosphatase 10.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	0.460
N300_10426	N300_02134	A0A091IFM5	A0A091I886	Adiponectin.	Progestin and adipoQ receptor family member 3.	0.885
N300_10809	N300_06496	A0A091HXK2	A0A091IAG4	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	Receptor-type tyrosine-protein phosphatase eta.	0.434
N300_10809	N300_09618	A0A091HXK2	A0A091I4T0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	Dual specificity protein phosphatase 10.	0.460
N300_10809	N300_14129	A0A091HXK2	A0A091IBY0	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	Tyrosine-protein phosphatase non-receptor type 6.	0.890
N300_10809	N300_14562	A0A091HXK2	A0A091HRD7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	Inositol polyphosphate 5-phosphatase K.	0.429
N300_10809	N300_15381	A0A091HXK2	A0A091HKW6	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	Dual specificity protein phosphatase 19.	0.460
N300_10809	N300_15402	A0A091HXK2	A0A091ID16	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family.	Tyrosine-protein kinase.	0.875
N300_11086	N300_14058	A0A091HNJ3	A0A091IL49	Protein sprouty 2.	Protein sprouty 1.	0.705
N300_11086	N300_14129	A0A091HNJ3	A0A091IBY0	Protein sprouty 2.	Tyrosine-protein phosphatase non-receptor type 6.	0.583
N300_11086	N300_15402	A0A091HNJ3	A0A091ID16	Protein sprouty 2.	Tyrosine-protein kinase.	0.454
N300_13687	N300_04398	A0A091IF12	A0A091J4F6	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.878