(19 nodes) Negative regulation of neuron differentiation network (Calypte anna)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	N300_02824	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (611 aa)
	N300_06106	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1571 aa)
	N300_10475	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
	N300_01428	Patched domain-containing protein 2. (1342 aa)
	N300_05040	Transcription factor Sox-9. (417 aa)
	N300_09747	Oligodendrocyte transcription factor 3. (191 aa)
	N300_14933	RE1-silencing transcription factor. (890 aa)
	N300_07268	E3 ubiquitin-protein ligase TTC3. (1891 aa)
	N300_12938	E3 ubiquitin-protein ligase MIB1. (931 aa)
	N300_05492	Follistatin. (316 aa)
	N300_04553	Homeobox protein DLX-1. (255 aa)
	N300_06370	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1193 aa)
	N300_13683	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	N300_10619	Ciliary neurotrophic factor. (195 aa)
	N300_03130	U6 snRNA-associated Sm-like LSm1. (95 aa)
	N300_12278	Uncharacterized protein C3orf17. (239 aa)
	N300_03845	Iroquois-class homeodomain protein irx-3. (67 aa)
	N300_04087	Paired mesoderm homeobox protein 2B. (141 aa)
	N300_05929	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (635 aa)

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_02824	N300_06370	A0A091IL56	A0A091IBU1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.578
N300_02824	N300_12938	A0A091IL56	A0A091I8R9	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	E3 ubiquitin-protein ligase MIB1.	0.556
N300_03845	N300_09747	A0A091IGK0	A0A091I0T3	Iroquois-class homeodomain protein irx-3.	Oligodendrocyte transcription factor 3.	0.476
N300_06370	N300_02824	A0A091IBU1	A0A091IL56	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.578
N300_06370	N300_12938	A0A091IBU1	A0A091I8R9	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	E3 ubiquitin-protein ligase MIB1.	0.601
N300_09747	N300_03845	A0A091I0T3	A0A091IGK0	Oligodendrocyte transcription factor 3.	Iroquois-class homeodomain protein irx-3.	0.476
N300_12938	N300_02824	A0A091I8R9	A0A091IL56	E3 ubiquitin-protein ligase MIB1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.556
N300_12938	N300_06370	A0A091I8R9	A0A091IBU1	E3 ubiquitin-protein ligase MIB1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.601