(97 nodes) Positive regulation of growth network (Calypte anna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	N300_12085	Wolframin. (809 aa)
	N300_09113	IST1. (365 aa)
	N300_06556	Eukaryotic translation initiation factor 4 gamma 2. (916 aa)
	N300_12359	Nipped-B-like. (159 aa)
	N300_15343	Disintegrin and metalloproteinase domain-containing protein 17. (797 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (560 aa)
	N300_00618	Transcription factor AP-1; Belongs to the bZIP family. (316 aa)
	N300_05415	E3 ubiquitin-protein ligase parkin. (234 aa)
	N300_03445	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor Fz/Smo family. (421 aa)
	N300_09193	Uncharacterized protein. (123 aa)
	N300_12362	Nipped-B protein. (822 aa)
	N300_05723	Cyclin-dependent kinase-like 5. (837 aa)
	N300_06510	Myogenic factor. (298 aa)
	N300_08509	Mothers against decapentaplegic 7. (181 aa)
	N300_06560	Ubiquitin carboxyl-terminal hydrolase 47. (1344 aa)
	N300_04618	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (829 aa)
	N300_03099	Parvalbumin, thymic CPV3; Belongs to the parvalbumin family. (109 aa)
	N300_06227	Microtubule-associated protein. (652 aa)
	N300_06191	Rho-related GTP-binding protein RhoN. (174 aa)
	N300_03280	VIP peptides. (101 aa)
	N300_04592	Shootin-1. (606 aa)
	N300_10710	Exostosin-like 3; Belongs to the glycosyltransferase 47 family. (913 aa)
	N300_13558	Disrupted in schizophrenia 1 protein. (471 aa)
	N300_12501	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
	N300_02935	Drebrin-like. (330 aa)
	N300_14312	D(2) dopamine receptor. (457 aa)
	N300_12634	Apoptosis regulator Bcl-2. (239 aa)
	N300_01418	Cell division control protein 42. (163 aa)
	N300_01468	Mitochondrial ubiquitin ligase activator of NFKB 1. (310 aa)
	N300_04187	CDKN2A-interacting protein. (524 aa)
	N300_11611	Bardet-Biedl syndrome 2 protein. (682 aa)
	N300_07402	Nipped-B-like. (207 aa)
	N300_03537	Transient receptor potential cation channel subfamily V member 2. (713 aa)
	N300_05068	Regulatory-associated protein of mTOR. (1335 aa)
	N300_06684	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
	N300_11253	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (313 aa)
	N300_10406	Mothers against decapentaplegic 7. (196 aa)
	N300_01540	Endothelin-1. (162 aa)
	N300_11117	Down syndrome cell adhesion molecule. (155 aa)
	N300_15769	Activity-dependent neuroprotector homeobox protein. (1110 aa)
	N300_11456	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	N300_09625	Ezrin. (582 aa)
	N300_11526	Nucleolar protein 12. (190 aa)
	N300_09413	Major facilitator superfamily domain-containing protein 2A. (456 aa)
	N300_03238	Zinc finger protein 639. (483 aa)
	N300_09874	Zona pellucida sperm-binding protein 3. (298 aa)
	N300_07705	Uncharacterized protein. (723 aa)
	N300_02533	Hepatoma-derived growth factor-related protein 2. (575 aa)
	N300_01379	Zinc finger protein ZPR1. (341 aa)
	N300_14557	Synaptotagmin-4. (414 aa)
	N300_09875	Zona pellucida sperm-binding protein 3. (299 aa)
	N300_06597	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (246 aa)
	N300_09825	BRCA1-associated ATM activator 1. (822 aa)
	N300_07993	Anaphase-promoting complex subunit 2; Belongs to the cullin family. (783 aa)
	N300_08040	E3 ubiquitin-protein ligase TRIM32. (649 aa)
	N300_03707	Synaptotagmin-2. (403 aa)
	N300_08845	DNA helicase INO80. (1566 aa)
	N300_07777	Semaphorin-4E. (622 aa)
	N300_09241	Tyrosine-protein kinase receptor. (748 aa)
	N300_12803	RING finger protein 157. (577 aa)
	N300_11291	SAM and SH3 domain-containing protein 3. (279 aa)
	N300_13260	Calpain-3; Belongs to the peptidase C2 family. (809 aa)
	N300_13753	Nipped-B-like. (563 aa)
	N300_12525	Protrudin. (332 aa)
	N300_06368	McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (572 aa)
	N300_12075	Growth hormone-releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (405 aa)
	N300_14029	Myotrophin. (98 aa)
	N300_10376	Intersectin-2. (1637 aa)
	N300_07216	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (216 aa)
	N300_07486	Leucine-rich glioma-inactivated protein 1. (551 aa)
	N300_15279	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (435 aa)
	N300_10530	Raftlin. (601 aa)
	N300_15276	ADNP homeobox protein 2. (1041 aa)
	N300_05822	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (469 aa)
	N300_05575	Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (438 aa)
	N300_04806	T-box transcription factor TBX20. (172 aa)
	N300_07948	Somatotropin. (93 aa)
	N300_13514	Growth hormone receptor. (588 aa)
	N300_02824	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (611 aa)
	N300_07405	Nipped-B protein. (817 aa)
	N300_02958	Interleukin-7. (130 aa)
	N300_04658	26S proteasome non-ATPase regulatory subunit 10. (189 aa)
	N300_04693	COMM domain-containing protein 5. (177 aa)
	N300_14938	Homeodomain-only protein. (73 aa)
	N300_11933	Disintegrin and metalloproteinase domain-containing protein 10. (731 aa)
	N300_15802	Zona pellucida sperm-binding protein 3. (295 aa)
	N300_12720	Phospholipase A-2-activating protein. (747 aa)
	N300_07327	HemK methyltransferase family member 2. (171 aa)
	N300_09617	H2.0-like homeobox protein. (137 aa)
	N300_11116	Down syndrome cell adhesion molecule. (1726 aa)
	N300_02111	Protein RUFY3. (457 aa)
	N300_03211	Cytoplasmic FMR1-interacting protein 1. (1254 aa)
	N300_07779	Putative ATP-dependent RNA helicase DDX49; Belongs to the DEAD box helicase family. (449 aa)
	N300_03914	Zinc finger protein ZFPM2. (1050 aa)
	N300_08146	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (191 aa)
	N300_06925	Synaptotagmin-17. (464 aa)
	N300_14070	Exosome complex component RRP45. (410 aa)

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_00618	N300_12634	A0A091HM51	A0A091HUI8	Transcription factor AP-1; Belongs to the bZIP family.	Apoptosis regulator Bcl-2.	0.491
N300_01418	N300_03099	A0A091HUM3	A0A091HPX6	Cell division control protein 42.	Parvalbumin, thymic CPV3; Belongs to the parvalbumin family.	0.425
N300_01418	N300_03211	A0A091HUM3	A0A091IX59	Cell division control protein 42.	Cytoplasmic FMR1-interacting protein 1.	0.771
N300_01418	N300_05068	A0A091HUM3	A0A091I252	Cell division control protein 42.	Regulatory-associated protein of mTOR.	0.573
N300_01418	N300_05415	A0A091HUM3	A0A091HM91	Cell division control protein 42.	E3 ubiquitin-protein ligase parkin.	0.510
N300_01418	N300_05575	A0A091HUM3	A0A091IIC6	Cell division control protein 42.	Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.484
N300_01418	N300_06597	A0A091HUM3	A0A091IAS0	Cell division control protein 42.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.481
N300_01418	N300_06684	A0A091HUM3	A0A091I2S0	Cell division control protein 42.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.493
N300_01418	N300_07777	A0A091HUM3	A0A091ICR2	Cell division control protein 42.	Semaphorin-4E.	0.445
N300_01418	N300_09241	A0A091HUM3	A0A091ID17	Cell division control protein 42.	Tyrosine-protein kinase receptor.	0.458
N300_01418	N300_09625	A0A091HUM3	A0A091I6Y8	Cell division control protein 42.	Ezrin.	0.679
N300_01418	N300_10376	A0A091HUM3	A0A091IFK6	Cell division control protein 42.	Intersectin-2.	0.998
N300_01418	N300_11116	A0A091HUM3	A0A091IV56	Cell division control protein 42.	Down syndrome cell adhesion molecule.	0.467
N300_01418	N300_11117	A0A091HUM3	A0A091I5M1	Cell division control protein 42.	Down syndrome cell adhesion molecule.	0.467
N300_01418	N300_15279	A0A091HUM3	A0A091IG30	Cell division control protein 42.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.446
N300_01468	N300_04693	A0A091HUS3	A0A091IM40	Mitochondrial ubiquitin ligase activator of NFKB 1.	COMM domain-containing protein 5.	0.558
N300_01468	N300_05415	A0A091HUS3	A0A091HM91	Mitochondrial ubiquitin ligase activator of NFKB 1.	E3 ubiquitin-protein ligase parkin.	0.416
N300_01540	N300_12501	A0A091I5H4	A0A091HT20	Endothelin-1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.448
N300_01540	N300_14312	A0A091I5H4	A0A091HU08	Endothelin-1.	D(2) dopamine receptor.	0.887
N300_02111	N300_04592	A0A091IVL3	A0A091HSA4	Protein RUFY3.	Shootin-1.	0.516