(96 nodes) Mitotic Spindle Checkpoint network (Calypte anna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	N300_06596	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (869 aa)
	N300_06022	Protein RCC2. (433 aa)
	N300_02229	Centromere protein O. (270 aa)
	N300_08264	Dynein light chain. (89 aa)
	N300_01763	Mitotic spindle assembly checkpoint protein MAD2A. (206 aa)
	N300_05825	Nuclear migration protein nudC. (309 aa)
	N300_01646	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (435 aa)
	N300_03050	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
	PAFAH1B1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
	N300_15853	Cytoplasmic dynein 1 heavy chain 1. (4559 aa)
	N300_12777	Nuclear distribution protein nudE-like 1. (315 aa)
	N300_09836	Mitotic spindle assembly checkpoint protein MAD1. (665 aa)
	N300_12892	Microtubule-associated protein RP/EB family member 2. (286 aa)
	N300_03616	CLIP-associating protein 1. (1473 aa)
	N300_11434	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform. (484 aa)
	N300_11251	Uncharacterized protein C17orf104. (244 aa)
	N300_13668	Centromere protein T. (112 aa)
	N300_02584	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (917 aa)
	N300_06961	Protein ELYS. (2286 aa)
	N300_07610	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (439 aa)
	N300_01483	CLIP-associating protein 2. (1457 aa)
	N300_15259	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (723 aa)
	N300_13880	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (232 aa)
	N300_05971	Centromere protein S. (115 aa)
	N300_07230	CAP-Gly domain-containing linker protein 2. (1017 aa)
	N300_07100	Mitotic checkpoint protein BUB3. (323 aa)
	N300_15212	Centromere protein I. (742 aa)
	N300_08262	Dynein light chain. (92 aa)
	N300_11477	Nuclear pore complex protein Nup133. (1076 aa)
	N300_14084	Dynein light chain. (91 aa)
	N300_08687	Uncharacterized protein. (188 aa)
	N300_04405	Protein SEC13; Belongs to the WD repeat SEC13 family. (304 aa)
	N300_05531	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (723 aa)
	N300_10177	Mitotic checkpoint serine/threonine-protein kinase BUB1. (1084 aa)
	N300_10210	Centromere protein L. (285 aa)
	N300_10661	Protein CASC5. (504 aa)
	N300_02182	Centromere protein Q. (210 aa)
	N300_10634	Inner centromere protein. (378 aa)
	N300_07993	Anaphase-promoting complex subunit 2; Belongs to the cullin family. (783 aa)
	N300_06353	Exportin-1. (1075 aa)
	N300_15854	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform. (541 aa)
	SPDL1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (606 aa)
	N300_10204	Kinetochore protein Nuf2. (469 aa)
	N300_15627	Microtubule-associated protein RP/EB family member 1. (263 aa)
	N300_12951	Kinetochore protein NDC80. (640 aa)
	N300_09939	Centromere protein P. (188 aa)
	N300_09667	Nucleoporin Nup43. (265 aa)
	N300_07747	Ubiquitin-conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (136 aa)
	N300_11438	Kinetochore-associated protein NSL1. (311 aa)
	N300_11447	Centromere protein F. (114 aa)
	N300_15099	E3 SUMO-protein ligase RanBP2. (155 aa)
	N300_07733	Anaphase-promoting complex subunit 16. (110 aa)
	N300_06714	Shugoshin-like 1. (137 aa)
	N300_02079	Serine/threonine-protein phosphatase. (275 aa)
	N300_11446	Centromere protein F. (120 aa)
	N300_10987	Cell division cycle protein 23. (525 aa)
	N300_15089	Cell division cycle protein 16. (623 aa)
	N300_15069	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (142 aa)
	N300_11448	Centromere protein F. (190 aa)
	N300_06736	Baculoviral IAP repeat-containing protein 5.1. (147 aa)
	N300_15098	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (162 aa)
	N300_09459	Microtubule-associated tumor suppressor candidate 2. (1397 aa)
	N300_11032	Serine/threonine-protein phosphatase. (309 aa)
	N300_07119	Uncharacterized protein C17orf104. (211 aa)
	N300_04252	Protein zwilch. (577 aa)
	N300_09460	Microtubule-associated tumor suppressor candidate 2. (69 aa)
	N300_14311	Centromere/kinetochore protein zw10. (742 aa)
	N300_15497	Borealin. (122 aa)
	N300_11163	Spindle and kinetochore-associated protein 2. (89 aa)
	N300_04179	Centromere protein U. (313 aa)
	N300_03389	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (455 aa)
	N300_08686	Uncharacterized protein. (118 aa)
	N300_03412	Centromere protein N. (346 aa)
	N300_10691	Nuclear pore complex protein Nup160. (1326 aa)
	N300_10660	Uncharacterized protein. (48 aa)
	N300_06225	Cell division cycle protein 27. (825 aa)
	N300_00803	Cell division cycle protein 20. (504 aa)
	N300_00781	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (706 aa)
	N300_05288	Nucleoporin SEH1; Belongs to the WD repeat SEC13 family. (385 aa)
	N300_08932	Nuclear distribution protein nudE 1. (344 aa)
	N300_10674	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1054 aa)
	N300_04557	Cytoplasmic dynein 1 intermediate chain 2. (629 aa)
	N300_05394	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform. (594 aa)
	N300_10635	Inner centromere protein. (812 aa)
	N300_04581	Kinetochore protein Spc25. (231 aa)
	N300_00636	Centromere protein R. (161 aa)
	N300_13167	Centromere protein M. (159 aa)
	N300_10265	Anaphase-promoting complex subunit 5. (689 aa)
	N300_10935	Polyamine-modulated factor 1. (140 aa)
	N300_12323	DNA excision repair protein ERCC-6-like 2. (427 aa)
	N300_10290	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (308 aa)
	N300_10283	Kinetochore-associated protein 1. (2213 aa)
	N300_12322	Putative DNA repair and recombination protein RAD26-like. (684 aa)
	N300_10280	CAP-Gly domain-containing linker protein 1. (1435 aa)
	N300_10259	Anaphase-promoting complex subunit 7. (558 aa)
	N300_08649	Nucleoporin Nup37. (326 aa)

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_00636	N300_00803	A0A091HM67	A0A091HQM6	Centromere protein R.	Cell division cycle protein 20.	0.590
N300_00636	N300_01763	A0A091HM67	A0A091J5E5	Centromere protein R.	Mitotic spindle assembly checkpoint protein MAD2A.	0.601
N300_00636	N300_02182	A0A091HM67	A0A091IDD1	Centromere protein R.	Centromere protein Q.	0.988
N300_00636	N300_02229	A0A091HM67	A0A091J9E1	Centromere protein R.	Centromere protein O.	0.987
N300_00636	N300_03412	A0A091HM67	A0A091HSE6	Centromere protein R.	Centromere protein N.	0.972
N300_00636	N300_04179	A0A091HM67	A0A091HU35	Centromere protein R.	Centromere protein U.	0.987
N300_00636	N300_05825	A0A091HM67	A0A091J4V9	Centromere protein R.	Nuclear migration protein nudC.	0.557
N300_00636	N300_05971	A0A091HM67	A0A091III7	Centromere protein R.	Centromere protein S.	0.904
N300_00636	N300_08649	A0A091HM67	A0A091HGP2	Centromere protein R.	Nucleoporin Nup37.	0.443
N300_00636	N300_09939	A0A091HM67	A0A091I8A0	Centromere protein R.	Centromere protein P.	0.987
N300_00636	N300_10177	A0A091HM67	A0A091IDY4	Centromere protein R.	Mitotic checkpoint serine/threonine-protein kinase BUB1.	0.485
N300_00636	N300_10210	A0A091HM67	A0A091IDT3	Centromere protein R.	Centromere protein L.	0.706
N300_00636	N300_10674	A0A091HM67	A0A091HPG6	Centromere protein R.	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta.	0.544
N300_00636	N300_13167	A0A091HM67	A0A091HLS5	Centromere protein R.	Centromere protein M.	0.933
N300_00636	N300_13668	A0A091HM67	A0A091IQR2	Centromere protein R.	Centromere protein T.	0.972
N300_00636	N300_15212	A0A091HM67	A0A091IHX7	Centromere protein R.	Centromere protein I.	0.971
N300_00781	N300_00803	A0A091HQK6	A0A091HQM6	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Cell division cycle protein 20.	0.982
N300_00781	N300_01763	A0A091HQK6	A0A091J5E5	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Mitotic spindle assembly checkpoint protein MAD2A.	0.787
N300_00781	N300_03389	A0A091HQK6	A0A091HTB8	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.446
N300_00781	N300_03412	A0A091HQK6	A0A091HSE6	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Centromere protein N.	0.482