(125 nodes) Tight junction network (Calypte anna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	N300_15069	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (142 aa)
	N300_11007	Heat shock 70 kDa protein 4. (808 aa)
	N300_09642	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	N300_07282	Runt-related transcription factor 1. (315 aa)
	N300_01186	Leucine-rich repeat-containing protein 1. (472 aa)
	N300_13201	Uncharacterized protein. (53 aa)
	N300_07446	5'-AMP-activated protein kinase subunit gamma-2. (524 aa)
	N300_02079	Serine/threonine-protein phosphatase. (275 aa)
	N300_03610	Band 4.1-like 5. (576 aa)
	N300_13420	Partitioning defective 6 beta. (288 aa)
	N300_12942	Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1323 aa)
	N300_11751	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (192 aa)
	N300_02427	Liprin-alpha-1. (1240 aa)
	N300_09625	Ezrin. (582 aa)
	N300_09643	T-lymphoma invasion and metastasis-inducing protein 2. (523 aa)
	N300_03655	Extended synaptotagmin-3. (473 aa)
	N300_02420	G1/S-specific cyclin-D1; Belongs to the cyclin family. (292 aa)
	N300_11531	Eukaryotic translation initiation factor 3 subunit L. (547 aa)
	N300_09809	Actin, cytoplasmic 1; Belongs to the actin family. (374 aa)
	N300_02492	Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (449 aa)
	N300_00720	Myosin light polypeptide 6. (85 aa)
	N300_03698	Liprin-alpha-2. (1178 aa)
	N300_15701	Transcription factor GATA-5. (266 aa)
	N300_15770	Partitioning defective 6 beta. (347 aa)
	N300_12666	Symplekin. (760 aa)
	N300_06993	Blood vessel epicardial substance. (575 aa)
	N300_12820	Rho GTPase-activating protein 44. (524 aa)
	N300_03713	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (395 aa)
	N300_09843	MICAL-like 2. (833 aa)
	N300_09865	Actin, cytoplasmic type 5. (376 aa)
	N300_14136	Prolyl 3-hydroxylase 3. (741 aa)
	N300_11828	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (389 aa)
	N300_05238	Partitioning defective 6 gamma. (282 aa)
	N300_01699	Angiomotin-like 1. (655 aa)
	N300_13681	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1470 aa)
	N300_07807	Rho guanine nucleotide exchange factor 18. (1040 aa)
	N300_15807	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
	N300_09882	Moesin. (576 aa)
	N300_15231	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
	N300_05509	Mitogen-activated protein kinase kinase kinase 1. (1332 aa)
	N300_14352	Merlin. (443 aa)
	N300_15168	Ras-related protein Rap-2c. (93 aa)
	N300_01744	Disks large 2. (361 aa)
	N300_08344	Protein scribble. (455 aa)
	N300_01751	Mitogen-activated protein kinase. (426 aa)
	N300_07524	Mitogen-activated protein kinase. (427 aa)
	N300_04188	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (208 aa)
	N300_10073	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (424 aa)
	N300_09504	5'-AMP-activated protein kinase subunit gamma-1. (242 aa)
	N300_08311	Band 4.1-like 4A. (649 aa)
	N300_08278	5'-AMP-activated protein kinase subunit beta-1. (273 aa)
	N300_13229	E3 ubiquitin-protein ligase NEDD4-like. (942 aa)
	N300_05889	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
	N300_13623	Partitioning defective 3. (1270 aa)
	N300_13628	Integrin beta. (758 aa)
	N300_04932	Unconventional myosin-XV. (512 aa)
	N300_02344	Claudin-4. (209 aa)
	N300_08759	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (378 aa)
	N300_11026	Rap guanine nucleotide exchange factor 6. (807 aa)
	N300_12755	MARVEL domain-containing protein 2. (328 aa)
	N300_14466	Tight junction protein ZO-1. (1778 aa)
	N300_07275	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (236 aa)
	N300_07338	Junctional adhesion molecule B. (246 aa)
	N300_07450	Actin-related protein 3B; Belongs to the actin family. (403 aa)
	N300_10416	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
	N300_02429	Src substrate protein p85. (516 aa)
	N300_01386	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (177 aa)
	N300_07758	Ras-related protein Rab-8A. (161 aa)
	N300_01267	Radixin. (579 aa)
	N300_10071	Tubulin alpha-5 chain. (55 aa)
	N300_01984	MAGUK p55 subfamily member 5; Belongs to the MAGUK family. (675 aa)
	N300_12656	Protein kinase C iota type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (562 aa)
	N300_15329	Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1403 aa)
	N300_11532	MICAL-like 1. (904 aa)
	N300_10611	Mitogen-activated protein kinase. (420 aa)
	N300_13957	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (446 aa)
	N300_09477	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (423 aa)
	N300_14206	Rho GTPase-activating protein 17. (517 aa)
	N300_09106	MARVEL domain-containing protein 3. (200 aa)
	N300_00610	Non-specific serine/threonine protein kinase. (521 aa)
	N300_12654	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
	N300_01965	Alpha-actinin-1. (852 aa)
	N300_12084	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform. (386 aa)
	N300_00618	Transcription factor AP-1; Belongs to the bZIP family. (316 aa)
	N300_13959	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (443 aa)
	N300_05328	Myosin regulatory light chain 2, smooth muscle minor isoform. (176 aa)
	N300_15024	Ras-related protein Rab-8B. (170 aa)
	N300_15385	Transmembrane protein 237. (380 aa)
	N300_09192	Tight junction protein ZO-2; Belongs to the MAGUK family. (1162 aa)
	N300_04852	Junctional adhesion molecule C. (292 aa)
	N300_03278	Tyrosine-protein kinase. (418 aa)
	N300_01421	Claudin-19. (138 aa)
	N300_02768	DOMON domain-containing protein FRRS1L. (211 aa)
	N300_13805	WASP homolog-associated protein with actin, membranes and microtubules. (592 aa)
	N300_14245	Nuclease-sensitive element-binding protein 1. (215 aa)
	N300_10471	Rho-related GTP-binding protein RhoC. (193 aa)
	N300_10481	Ras-related protein Rap-1A. (158 aa)
	N300_09499	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (292 aa)
	N300_14584	Merlin. (552 aa)
	N300_10972	Uncharacterized protein. (236 aa)
	N300_00828	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	N300_04189	Claudin-22. (158 aa)
	N300_01894	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (259 aa)
	N300_01905	Angiomotin-like 2. (737 aa)
	N300_10795	Myosin regulatory light polypeptide 9. (176 aa)
	N300_01418	Cell division control protein 42. (163 aa)
	N300_01422	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (188 aa)
	N300_13336	Prolyl 3-hydroxylase 2. (548 aa)
	N300_14946	Claudin-23. (188 aa)
	N300_13334	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
	N300_14991	Rap guanine nucleotide exchange factor 2. (816 aa)
	N300_11944	E3 ubiquitin-protein ligase NEDD4. (887 aa)
	N300_07424	Non-specific serine/threonine protein kinase. (517 aa)
	N300_12635	MARVEL domain-containing protein 3. (262 aa)
	N300_00536	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (452 aa)
	N300_13307	Disks large 1. (711 aa)
	N300_13335	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	N300_10991	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (420 aa)
	N300_02998	Actin-related protein 3; Belongs to the actin family. (402 aa)
	N300_11032	Serine/threonine-protein phosphatase. (309 aa)
	N300_04900	Na(+)/H(+) exchange regulatory cofactor NHE-RF1. (207 aa)
	N300_12216	Tight junction-associated protein 1. (583 aa)
	N300_02718	5'-AMP-activated protein kinase subunit beta-2. (274 aa)
	N300_07336	GA-binding protein alpha chain. (446 aa)
	N300_09077	Unconventional myosin-VIIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2192 aa)

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_00536	N300_00720	A0A091HYZ0	A0A091I951	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Myosin light polypeptide 6.	0.401
N300_00536	N300_01418	A0A091HYZ0	A0A091HUM3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Cell division control protein 42.	0.882
N300_00536	N300_02998	A0A091HYZ0	A0A091I1B7	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Actin-related protein 3; Belongs to the actin family.	0.524
N300_00536	N300_03278	A0A091HYZ0	A0A091HS58	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tyrosine-protein kinase.	0.439
N300_00536	N300_05328	A0A091HYZ0	A0A091HNI9	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Myosin regulatory light chain 2, smooth muscle minor isoform.	0.408
N300_00536	N300_07450	A0A091HYZ0	A0A091IU88	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Actin-related protein 3B; Belongs to the actin family.	0.584
N300_00536	N300_08759	A0A091HYZ0	A0A091IQ40	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.511
N300_00536	N300_09192	A0A091HYZ0	A0A091HR54	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tight junction protein ZO-2; Belongs to the MAGUK family.	0.476
N300_00536	N300_09809	A0A091HYZ0	A0A091I8G7	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Actin, cytoplasmic 1; Belongs to the actin family.	0.686
N300_00536	N300_09865	A0A091HYZ0	A0A091IAR1	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Actin, cytoplasmic type 5.	0.685
N300_00536	N300_10471	A0A091HYZ0	A0A091HTF8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Rho-related GTP-binding protein RhoC.	0.455
N300_00536	N300_10795	A0A091HYZ0	A0A091HUM2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Myosin regulatory light polypeptide 9.	0.408
N300_00536	N300_11007	A0A091HYZ0	A0A091I3R7	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Heat shock 70 kDa protein 4.	0.478
N300_00536	N300_12942	A0A091HYZ0	A0A091I6L8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.603
N300_00536	N300_14466	A0A091HYZ0	A0A091ITP3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tight junction protein ZO-1.	0.840
N300_00536	N300_15329	A0A091HYZ0	A0A091HJA0	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Rho-associated protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.603
N300_00610	N300_00720	A0A091HK93	A0A091I951	Non-specific serine/threonine protein kinase.	Myosin light polypeptide 6.	0.525
N300_00610	N300_00828	A0A091HK93	A0A091HTZ5	Non-specific serine/threonine protein kinase.	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	0.887
N300_00610	N300_02492	A0A091HK93	A0A091I8T8	Non-specific serine/threonine protein kinase.	Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily.	0.932
N300_00610	N300_02718	A0A091HK93	A0A091I2L6	Non-specific serine/threonine protein kinase.	5'-AMP-activated protein kinase subunit beta-2.	0.992