(78 nodes) Gap junction network (Calypte anna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	N300_12705	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	N300_01728	Metabotropic glutamate receptor 5. (929 aa)
	N300_07986	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (356 aa)
	N300_10016	Guanine nucleotide-binding protein G(I) subunit alpha-2. (315 aa)
	N300_09856	Platelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (141 aa)
	N300_13984	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (412 aa)
	N300_14466	Tight junction protein ZO-1. (1778 aa)
	N300_06303	GTPase HRas. (189 aa)
	N300_14981	Platelet-derived growth factor C. (306 aa)
	N300_08718	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (367 aa)
	N300_10546	Metabotropic glutamate receptor 1. (1157 aa)
	N300_12609	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (426 aa)
	N300_10149	Guanylate cyclase soluble subunit beta-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (672 aa)
	N300_01302	GTP-binding protein GEM. (297 aa)
	N300_01288	Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (536 aa)
	N300_05575	Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (438 aa)
	N300_07565	cGMP-dependent protein kinase 1. (144 aa)
	N300_07211	Inositol 1,4,5-trisphosphate receptor type 2. (54 aa)
	N300_08178	Mitogen-activated protein kinase. (320 aa)
	N300_03383	GTP-binding protein RAD. (217 aa)
	N300_04391	Inositol 1,4,5-trisphosphate receptor type 1. (2706 aa)
	N300_12251	Son of sevenless 2. (1300 aa)
	N300_10875	Mitogen-activated protein kinase 7. (232 aa)
	N300_15183	5-hydroxytryptamine receptor 2C. (463 aa)
	N300_07567	cGMP-dependent protein kinase 1. (529 aa)
	N300_09224	Guanine nucleotide-binding protein G(Q) subunit alpha. (314 aa)
	N300_06361	Phosphoinositide phospholipase C. (1064 aa)
	N300_03682	Guanine nucleotide-binding protein G(K) subunit alpha. (319 aa)
	N300_01670	Platelet-derived growth factor D. (269 aa)
	N300_11828	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (389 aa)
	N300_12671	Guanine nucleotide-binding protein G(Q) subunit alpha. (245 aa)
	N300_03713	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (395 aa)
	N300_15732	Guanine nucleotide-binding protein G(S) subunit alpha. (334 aa)
	N300_10590	Platelet-derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1040 aa)
	N300_05150	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1181 aa)
	N300_02522	Guanine nucleotide-binding protein subunit alpha-11. (315 aa)
	N300_13030	D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	N300_15728	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (437 aa)
	N300_13986	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (816 aa)
	N300_15645	GTP-binding protein GEM. (144 aa)
	N300_01572	Adenylate cyclase type 1. (1088 aa)
	N300_03598	Mitogen-activated protein kinase kinase kinase 2. (569 aa)
	N300_09577	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (381 aa)
	N300_03630	Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (887 aa)
	N300_14973	Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
	N300_05122	Casein kinase I isoform delta. (389 aa)
	N300_13358	5-hydroxytryptamine receptor 2B. (429 aa)
	N300_00536	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (452 aa)
	N300_05018	Protein kinase C alpha type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (597 aa)
	N300_04924	Growth factor receptor-bound protein 2. (217 aa)
	N300_11912	5-hydroxytryptamine receptor 2A. (471 aa)
	N300_11141	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (279 aa)
	N300_14974	Guanylate cyclase soluble subunit beta-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (612 aa)
	N300_11607	Guanine nucleotide-binding protein G(O) subunit alpha. (103 aa)
	N300_14312	D(2) dopamine receptor. (457 aa)
	N300_00828	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	N300_09499	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (292 aa)
	N300_10455	GTPase NRas. (188 aa)
	N300_07903	Inositol 1,4,5-trisphosphate receptor type 2. (2675 aa)
	N300_03278	Tyrosine-protein kinase. (418 aa)
	N300_02001	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (220 aa)
	N300_02797	Adenylate cyclase type 2. (1034 aa)
	N300_10671	Phosphoinositide phospholipase C. (811 aa)
	N300_10454	Cold shock domain-containing protein E1. (763 aa)
	N300_12102	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (363 aa)
	N300_05377	Son of sevenless 1. (1289 aa)
	N300_07899	GTPase KRas. (188 aa)
	N300_05295	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
	N300_13959	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (443 aa)
	N300_08454	Adenylate cyclase type 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (946 aa)
	N300_14214	Protein kinase C beta type. (43 aa)
	N300_13957	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (446 aa)
	N300_14213	Protein kinase C beta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (601 aa)
	N300_11555	Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (223 aa)
	N300_10964	RAF proto-oncogene serine/threonine-protein kinase. (647 aa)
	N300_10071	Tubulin alpha-5 chain. (55 aa)
	N300_09138	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (425 aa)
	N300_10073	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (424 aa)

Your Current Organism:

Calypte anna

NCBI taxonomy Id: 9244
Other names: C. anna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N300_00536	N300_01728	A0A091HYZ0	A0A091J2K6	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Metabotropic glutamate receptor 5.	0.459
N300_00536	N300_03278	A0A091HYZ0	A0A091HS58	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tyrosine-protein kinase.	0.439
N300_00536	N300_05295	A0A091HYZ0	A0A091HNH1	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.941
N300_00536	N300_07986	A0A091HYZ0	A0A091IZR8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.845
N300_00536	N300_09138	A0A091HYZ0	A0A091HH53	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.870
N300_00536	N300_10546	A0A091HYZ0	A0A091ILA2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Metabotropic glutamate receptor 1.	0.459
N300_00536	N300_12609	A0A091HYZ0	A0A091IJW1	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.941
N300_00536	N300_14466	A0A091HYZ0	A0A091ITP3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tight junction protein ZO-1.	0.840
N300_00536	N300_15728	A0A091HYZ0	A0A091I762	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.941
N300_00828	N300_01288	A0A091HTZ5	A0A091IJD8	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.489
N300_00828	N300_01302	A0A091HTZ5	A0A091IJH4	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	GTP-binding protein GEM.	0.532
N300_00828	N300_01572	A0A091HTZ5	A0A091I5J5	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Adenylate cyclase type 1.	0.887
N300_00828	N300_02797	A0A091HTZ5	A0A091HRS0	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Adenylate cyclase type 2.	0.879
N300_00828	N300_03383	A0A091HTZ5	A0A091IHJ4	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	GTP-binding protein RAD.	0.532
N300_00828	N300_03630	A0A091HTZ5	A0A091I4A3	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Adenylate cyclase type 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.892
N300_00828	N300_03682	A0A091HTZ5	A0A091ICP3	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.709
N300_00828	N300_04391	A0A091HTZ5	A0A091IH39	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Inositol 1,4,5-trisphosphate receptor type 1.	0.857
N300_00828	N300_05122	A0A091HTZ5	A0A091I016	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Casein kinase I isoform delta.	0.843
N300_00828	N300_05377	A0A091HTZ5	A0A091HPD1	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Son of sevenless 1.	0.634
N300_00828	N300_05575	A0A091HTZ5	A0A091IIC6	cAMP-dependent protein kinase catalytic subunit beta; Belongs to the protein kinase superfamily.	Dual specificity mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily.	0.582