(69 nodes) Mixed, incl. Regulation of signaling by CBL, and SH2 domain network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6W8B0_ORNAN	Uncharacterized protein. (211 aa)
	F7EG87_ORNAN	Uncharacterized protein. (224 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1521 aa)
	NCK1	NCK adaptor protein 1. (315 aa)
	F6QDR7_ORNAN	Uncharacterized protein. (284 aa)
	PIK3R2	Uncharacterized protein. (724 aa)
	VAV2-2	Calponin-homology (CH) domain-containing protein. (127 aa)
	VAV2	Uncharacterized protein. (723 aa)
	F7A7F5_ORNAN	Cbl-PTB domain-containing protein. (212 aa)
	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1053 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	F7FRJ2_ORNAN	SH3 domain-containing protein. (75 aa)
	SH3KBP1	Uncharacterized protein. (1349 aa)
	BTK	Tyrosine-protein kinase. (657 aa)
	PIK3R1	SH2 domain-containing protein. (230 aa)
	ITK	Tyrosine-protein kinase. (627 aa)
	F6VL77_ORNAN	Uncharacterized protein. (358 aa)
	YES1	Tyrosine-protein kinase. (464 aa)
	LYN	Tyrosine-protein kinase. (514 aa)
	TEC	Tyrosine-protein kinase. (585 aa)
	PIK3R3	Uncharacterized protein. (462 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (482 aa)
	PTPN11	Uncharacterized protein. (368 aa)
	PXN	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (580 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (300 aa)
	SHC2	Uncharacterized protein. (553 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1142 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (749 aa)
	F7B9D8_ORNAN	Uncharacterized protein. (599 aa)
	CRK	CRK proto-oncogene, adaptor protein. (282 aa)
	LCP2	Lymphocyte cytosolic protein 2. (530 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1053 aa)
	F6PLS0_ORNAN	Uncharacterized protein. (129 aa)
	F6YFD5_ORNAN	WH2 domain-containing protein. (503 aa)
	FGR	Tyrosine-protein kinase. (530 aa)
	FYN	Tyrosine-protein kinase. (455 aa)
	RAC2	Rac family small GTPase 2. (192 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	GAB1	GRB2 associated binding protein 1. (648 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1333 aa)
	F7C7M4_ORNAN	SH3 domain-containing protein. (143 aa)
	NCK2	Uncharacterized protein. (317 aa)
	F6WE73_ORNAN	Uncharacterized protein. (548 aa)
	GRAP2	GRB2 related adaptor protein 2. (326 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1260 aa)
	VAV1	Uncharacterized protein. (454 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1214 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (462 aa)
	F7CH03_ORNAN	Uncharacterized protein. (270 aa)
	F6XI85_ORNAN	Uncharacterized protein. (373 aa)
	F7FX95_ORNAN	SH2 domain-containing protein. (177 aa)
	ENSOANP00000026171	annotation not available (132 aa)
	CBL	UBA domain-containing protein. (226 aa)
	VAV3	Uncharacterized protein. (171 aa)
	PLCG1	Uncharacterized protein. (265 aa)
	F6SQK0_ORNAN	DH domain-containing protein. (147 aa)
	ERBB3	Protein kinase domain-containing protein. (235 aa)
	PIK3R5	Uncharacterized protein. (286 aa)
	K7E7K8_ORNAN	Pkinase_Tyr domain-containing protein. (233 aa)
	K7E7U1_ORNAN	Uncharacterized protein. (81 aa)
	PLCG2	SH2 domain-containing protein. (238 aa)
	TIAM1	Uncharacterized protein. (137 aa)
	K7EAQ6_ORNAN	Rho-GAP domain-containing protein. (200 aa)
	BLNK	SH2 domain-containing protein. (106 aa)
	ENSOANP00000031210	annotation not available (90 aa)
	K7EE78_ORNAN	SH3 domain-containing protein. (155 aa)
	K7EFU7_ORNAN	Uncharacterized protein. (344 aa)
	K7EHZ5_ORNAN	Uncharacterized protein. (72 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLNK	BTK	ENSOANP00000030762	ENSOANP00000006710	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.979
BLNK	CBL	ENSOANP00000030762	ENSOANP00000026620	SH2 domain-containing protein.	UBA domain-containing protein.	0.437
BLNK	F6PLS0_ORNAN	ENSOANP00000030762	ENSOANP00000013236	SH2 domain-containing protein.	Uncharacterized protein.	0.875
BLNK	F6QDR7_ORNAN	ENSOANP00000030762	ENSOANP00000001648	SH2 domain-containing protein.	Uncharacterized protein.	0.476
BLNK	F6SQK0_ORNAN	ENSOANP00000030762	ENSOANP00000027728	SH2 domain-containing protein.	DH domain-containing protein.	0.476
BLNK	F6VL77_ORNAN	ENSOANP00000030762	ENSOANP00000008181	SH2 domain-containing protein.	Uncharacterized protein.	0.917
BLNK	F6WE73_ORNAN	ENSOANP00000030762	ENSOANP00000022624	SH2 domain-containing protein.	Uncharacterized protein.	0.453
BLNK	F7A7F5_ORNAN	ENSOANP00000030762	ENSOANP00000004852	SH2 domain-containing protein.	Cbl-PTB domain-containing protein.	0.575
BLNK	F7CH03_ORNAN	ENSOANP00000030762	ENSOANP00000025035	SH2 domain-containing protein.	Uncharacterized protein.	0.476
BLNK	F7EG87_ORNAN	ENSOANP00000030762	ENSOANP00000000526	SH2 domain-containing protein.	Uncharacterized protein.	0.451
BLNK	F7FRJ2_ORNAN	ENSOANP00000030762	ENSOANP00000005740	SH2 domain-containing protein.	SH3 domain-containing protein.	0.507
BLNK	GRAP2	ENSOANP00000030762	ENSOANP00000023109	SH2 domain-containing protein.	GRB2 related adaptor protein 2.	0.452
BLNK	ITK	ENSOANP00000030762	ENSOANP00000008068	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.463
BLNK	K7E7K8_ORNAN	ENSOANP00000030762	ENSOANP00000029515	SH2 domain-containing protein.	Pkinase_Tyr domain-containing protein.	0.704
BLNK	K7EE78_ORNAN	ENSOANP00000030762	ENSOANP00000031835	SH2 domain-containing protein.	SH3 domain-containing protein.	0.453
BLNK	LCP2	ENSOANP00000030762	ENSOANP00000012426	SH2 domain-containing protein.	Lymphocyte cytosolic protein 2.	0.951
BLNK	LYN	ENSOANP00000030762	ENSOANP00000008740	SH2 domain-containing protein.	Tyrosine-protein kinase.	0.962
BLNK	NCK1	ENSOANP00000030762	ENSOANP00000000957	SH2 domain-containing protein.	NCK adaptor protein 1.	0.607
BLNK	NCK2	ENSOANP00000030762	ENSOANP00000022369	SH2 domain-containing protein.	Uncharacterized protein.	0.507
BLNK	PLCG1	ENSOANP00000030762	ENSOANP00000026973	SH2 domain-containing protein.	Uncharacterized protein.	0.453