(7 nodes) Insulin receptor complex, and IRS activation network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6W873_ORNAN	Tyrosine-protein kinase receptor. (1150 aa)
	GRB10	Growth factor receptor bound protein 10. (596 aa)
	F7EVG8_ORNAN	Receptor protein-tyrosine kinase. (1063 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type. (376 aa)
	IGF1R	Recep_L_domain domain-containing protein. (214 aa)
	INSRR	Recep_L_domain domain-containing protein. (246 aa)
	K7EI96_ORNAN	Protein kinase domain-containing protein. (85 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6W873_ORNAN	F7EVG8_ORNAN	ENSOANP00000000256	ENSOANP00000002164	Tyrosine-protein kinase receptor.	Receptor protein-tyrosine kinase.	0.884
F6W873_ORNAN	GRB10	ENSOANP00000000256	ENSOANP00000000482	Tyrosine-protein kinase receptor.	Growth factor receptor bound protein 10.	0.838
F6W873_ORNAN	IGF1R	ENSOANP00000000256	ENSOANP00000030177	Tyrosine-protein kinase receptor.	Recep_L_domain domain-containing protein.	0.900
F6W873_ORNAN	INSRR	ENSOANP00000000256	ENSOANP00000033071	Tyrosine-protein kinase receptor.	Recep_L_domain domain-containing protein.	0.899
F6W873_ORNAN	K7EI96_ORNAN	ENSOANP00000000256	ENSOANP00000033253	Tyrosine-protein kinase receptor.	Protein kinase domain-containing protein.	0.524
F6W873_ORNAN	PTPN1	ENSOANP00000000256	ENSOANP00000013825	Tyrosine-protein kinase receptor.	Tyrosine-protein phosphatase non-receptor type.	0.892
F7EVG8_ORNAN	F6W873_ORNAN	ENSOANP00000002164	ENSOANP00000000256	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.884
F7EVG8_ORNAN	GRB10	ENSOANP00000002164	ENSOANP00000000482	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 10.	0.881
F7EVG8_ORNAN	IGF1R	ENSOANP00000002164	ENSOANP00000030177	Receptor protein-tyrosine kinase.	Recep_L_domain domain-containing protein.	0.973
F7EVG8_ORNAN	INSRR	ENSOANP00000002164	ENSOANP00000033071	Receptor protein-tyrosine kinase.	Recep_L_domain domain-containing protein.	0.761
F7EVG8_ORNAN	K7EI96_ORNAN	ENSOANP00000002164	ENSOANP00000033253	Receptor protein-tyrosine kinase.	Protein kinase domain-containing protein.	0.825
F7EVG8_ORNAN	PTPN1	ENSOANP00000002164	ENSOANP00000013825	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type.	0.967
GRB10	F6W873_ORNAN	ENSOANP00000000482	ENSOANP00000000256	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.838
GRB10	F7EVG8_ORNAN	ENSOANP00000000482	ENSOANP00000002164	Growth factor receptor bound protein 10.	Receptor protein-tyrosine kinase.	0.881
GRB10	IGF1R	ENSOANP00000000482	ENSOANP00000030177	Growth factor receptor bound protein 10.	Recep_L_domain domain-containing protein.	0.983
GRB10	INSRR	ENSOANP00000000482	ENSOANP00000033071	Growth factor receptor bound protein 10.	Recep_L_domain domain-containing protein.	0.507
GRB10	K7EI96_ORNAN	ENSOANP00000000482	ENSOANP00000033253	Growth factor receptor bound protein 10.	Protein kinase domain-containing protein.	0.507
IGF1R	F6W873_ORNAN	ENSOANP00000030177	ENSOANP00000000256	Recep_L_domain domain-containing protein.	Tyrosine-protein kinase receptor.	0.900
IGF1R	F7EVG8_ORNAN	ENSOANP00000030177	ENSOANP00000002164	Recep_L_domain domain-containing protein.	Receptor protein-tyrosine kinase.	0.973
IGF1R	GRB10	ENSOANP00000030177	ENSOANP00000000482	Recep_L_domain domain-containing protein.	Growth factor receptor bound protein 10.	0.983