(20 nodes) FGFR2 ligand binding and activation, and Fibroblast growth factor receptor activity network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGFRL1	Fibroblast growth factor receptor like 1. (357 aa)
	FGFR2	Receptor protein-tyrosine kinase. (642 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	FGFR1	Fibroblast growth factor receptor. (821 aa)
	FGFR3	Fibroblast growth factor receptor. (769 aa)
	FGF5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (152 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (87 aa)
	F6QKY2_ORNAN	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (735 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	KLB	Klotho beta. (1043 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (96 aa)
	FGF18	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (98 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	KL	Klotho; Belongs to the glycosyl hydrolase 1 family. (739 aa)
	F7EEG4_ORNAN	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (229 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F6QKY2_ORNAN	F7EEG4_ORNAN	ENSOANP00000011930	ENSOANP00000024978	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	0.645
F6QKY2_ORNAN	FGF1	ENSOANP00000011930	ENSOANP00000022448	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.917
F6QKY2_ORNAN	FGF10	ENSOANP00000011930	ENSOANP00000002663	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.717
F6QKY2_ORNAN	FGF17	ENSOANP00000011930	ENSOANP00000002138	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.801
F6QKY2_ORNAN	FGF18	ENSOANP00000011930	ENSOANP00000020199	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.831
F6QKY2_ORNAN	FGF19	ENSOANP00000011930	ENSOANP00000011803	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.912
F6QKY2_ORNAN	FGF22	ENSOANP00000011930	ENSOANP00000019027	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.772
F6QKY2_ORNAN	FGF3	ENSOANP00000011930	ENSOANP00000011800	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.803
F6QKY2_ORNAN	FGF4	ENSOANP00000011930	ENSOANP00000011801	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.846
F6QKY2_ORNAN	FGF5	ENSOANP00000011930	ENSOANP00000005659	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.822
F6QKY2_ORNAN	FGF6	ENSOANP00000011930	ENSOANP00000026402	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.828
F6QKY2_ORNAN	FGF7	ENSOANP00000011930	ENSOANP00000015581	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.814
F6QKY2_ORNAN	FGF9	ENSOANP00000011930	ENSOANP00000014371	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.809
F6QKY2_ORNAN	FGFR1	ENSOANP00000011930	ENSOANP00000005151	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor receptor.	0.517
F6QKY2_ORNAN	FGFR2	ENSOANP00000011930	ENSOANP00000000755	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Receptor protein-tyrosine kinase.	0.537
F6QKY2_ORNAN	FGFR3	ENSOANP00000011930	ENSOANP00000005325	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor receptor.	0.520
F6QKY2_ORNAN	KL	ENSOANP00000011930	ENSOANP00000024382	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Klotho; Belongs to the glycosyl hydrolase 1 family.	0.645
F6QKY2_ORNAN	KLB	ENSOANP00000011930	ENSOANP00000016391	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Klotho beta.	0.645
F7EEG4_ORNAN	F6QKY2_ORNAN	ENSOANP00000024978	ENSOANP00000011930	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.645
F7EEG4_ORNAN	FGF1	ENSOANP00000024978	ENSOANP00000022448	Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.451