STRINGSTRING
MEIOB MEIOB RPA2 RPA2 BLM BLM TOP3A TOP3A RPA1 RPA1 RMI1 RMI1 RAD52 RAD52 FANCM FANCM K7E8C1_ORNAN K7E8C1_ORNAN K7E8M8_ORNAN K7E8M8_ORNAN K7EGF0_ORNAN K7EGF0_ORNAN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEIOBMeiosis specific with OB-fold. (472 aa)
RPA2Replication protein A2. (235 aa)
BLMATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (769 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (940 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
RMI1RecQ mediated genome instability 1. (612 aa)
RAD52Uncharacterized protein. (95 aa)
FANCMUncharacterized protein. (1951 aa)
K7E8C1_ORNANUncharacterized protein. (85 aa)
K7E8M8_ORNANRECA_2 domain-containing protein. (216 aa)
K7EGF0_ORNAN3'-5' exonuclease domain-containing protein. (79 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.