(32 nodes) Polymerase switching, and Epsilon DNA polymerase complex network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHTF18	Uncharacterized protein. (486 aa)
	RAD17	Uncharacterized protein. (680 aa)
	CHTF8	Chromosome transmission fidelity factor 8. (122 aa)
	LIG1	DNA ligase. (828 aa)
	F7FJN1_ORNAN	AAA domain-containing protein. (350 aa)
	F6WX64_ORNAN	Uncharacterized protein. (210 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (471 aa)
	POLD3	Uncharacterized protein. (125 aa)
	RFC2	Replication factor C subunit 2. (316 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (387 aa)
	F7F484_ORNAN	Uncharacterized protein. (251 aa)
	RFC1	Replication factor C subunit 1. (1153 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1770 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (107 aa)
	RFC4	Replication factor C subunit 4. (228 aa)
	PRIM2	Uncharacterized protein. (164 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	F6XC55_ORNAN	DNA_pol_E_B domain-containing protein. (472 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	F6XP74_ORNAN	Uncharacterized protein. (178 aa)
	F7BRC7_ORNAN	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (214 aa)
	F6VQA8_ORNAN	ATPase_AAA_core domain-containing protein. (93 aa)
	F6QIT2_ORNAN	Uncharacterized protein. (155 aa)
	K7E8H6_ORNAN	Uncharacterized protein. (95 aa)
	POLE-2	DNA polymerase epsilon catalytic subunit A isoform X1. (127 aa)
	ENSOANP00000029989	annotation not available (91 aa)
	POLA2	Uncharacterized protein. (95 aa)
	POLD1	DNA polymerase. (287 aa)
	K7EF39_ORNAN	DNA_pol_B domain-containing protein. (96 aa)
	K7EFV9_ORNAN	Uncharacterized protein. (126 aa)
	ENSOANP00000032425	annotation not available (59 aa)
	K7EIB3_ORNAN	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (137 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHTF18	CHTF8	ENSOANP00000000739	ENSOANP00000003739	Uncharacterized protein.	Chromosome transmission fidelity factor 8.	0.961
CHTF18	ENSOANP00000029989	ENSOANP00000000739	ENSOANP00000029989	Uncharacterized protein.	annotation not available	0.671
CHTF18	ENSOANP00000032425	ENSOANP00000000739	ENSOANP00000032425	Uncharacterized protein.	annotation not available	0.754
CHTF18	F6QIT2_ORNAN	ENSOANP00000000739	ENSOANP00000028991	Uncharacterized protein.	Uncharacterized protein.	0.967
CHTF18	F6VQA8_ORNAN	ENSOANP00000000739	ENSOANP00000025991	Uncharacterized protein.	ATPase_AAA_core domain-containing protein.	0.862
CHTF18	F6WX64_ORNAN	ENSOANP00000000739	ENSOANP00000009530	Uncharacterized protein.	Uncharacterized protein.	0.604
CHTF18	F6XC55_ORNAN	ENSOANP00000000739	ENSOANP00000022420	Uncharacterized protein.	DNA_pol_E_B domain-containing protein.	0.526
CHTF18	F6XP74_ORNAN	ENSOANP00000000739	ENSOANP00000025138	Uncharacterized protein.	Uncharacterized protein.	0.950
CHTF18	F7BRC7_ORNAN	ENSOANP00000000739	ENSOANP00000025275	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.869
CHTF18	F7F484_ORNAN	ENSOANP00000000739	ENSOANP00000012906	Uncharacterized protein.	Uncharacterized protein.	0.534
CHTF18	F7FJN1_ORNAN	ENSOANP00000000739	ENSOANP00000005764	Uncharacterized protein.	AAA domain-containing protein.	0.941
CHTF18	FEN1	ENSOANP00000000739	ENSOANP00000012510	Uncharacterized protein.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.614
CHTF18	K7E8H6_ORNAN	ENSOANP00000000739	ENSOANP00000029833	Uncharacterized protein.	Uncharacterized protein.	0.604
CHTF18	K7EF39_ORNAN	ENSOANP00000000739	ENSOANP00000032146	Uncharacterized protein.	DNA_pol_B domain-containing protein.	0.804
CHTF18	K7EFV9_ORNAN	ENSOANP00000000739	ENSOANP00000032416	Uncharacterized protein.	Uncharacterized protein.	0.671
CHTF18	K7EIB3_ORNAN	ENSOANP00000000739	ENSOANP00000033270	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.754
CHTF18	LIG1	ENSOANP00000000739	ENSOANP00000004264	Uncharacterized protein.	DNA ligase.	0.510
CHTF18	POLA2	ENSOANP00000000739	ENSOANP00000031516	Uncharacterized protein.	Uncharacterized protein.	0.526
CHTF18	POLD1	ENSOANP00000000739	ENSOANP00000031804	Uncharacterized protein.	DNA polymerase.	0.817
CHTF18	POLD2	ENSOANP00000000739	ENSOANP00000010385	Uncharacterized protein.	DNA polymerase delta 2, accessory subunit.	0.522