(22 nodes) Activation of the pre-replicative complex network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MCM10	Minichromosome maintenance 10 replication initiation factor. (882 aa)
	ORC3	Origin recognition complex subunit 3. (616 aa)
	ORC6	Origin recognition complex subunit 6. (263 aa)
	F7AR20_ORNAN	Uncharacterized protein. (257 aa)
	DBF4	DBF4-type domain-containing protein. (405 aa)
	MCM2	DNA helicase; Belongs to the MCM family. (908 aa)
	MCM4	DNA helicase; Belongs to the MCM family. (863 aa)
	MCM6	MCM domain-containing protein; Belongs to the MCM family. (741 aa)
	ORC4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (435 aa)
	MCM8	MCM domain-containing protein; Belongs to the MCM family. (828 aa)
	MCM9	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1137 aa)
	F6TS55_ORNAN	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (653 aa)
	ORC2	Origin recognition complex subunit 2. (400 aa)
	MCM5	DNA helicase; Belongs to the MCM family. (609 aa)
	F7E3J1_ORNAN	CDT1 domain-containing protein. (445 aa)
	CDC7	Cell division cycle 7; Belongs to the protein kinase superfamily. (410 aa)
	ORC5	Origin recognition complex subunit 5. (435 aa)
	CDC6	AAA domain-containing protein. (372 aa)
	MCM3	MCM_OB domain-containing protein. (192 aa)
	CDC45	Uncharacterized protein. (146 aa)
	K7ECA8_ORNAN	Uncharacterized protein. (151 aa)
	K7ED41_ORNAN	Cdc6_C domain-containing protein. (115 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC45	CDC6	ENSOANP00000030904	ENSOANP00000024344	Uncharacterized protein.	AAA domain-containing protein.	0.714
CDC45	CDC7	ENSOANP00000030904	ENSOANP00000023290	Uncharacterized protein.	Cell division cycle 7; Belongs to the protein kinase superfamily.	0.738
CDC45	DBF4	ENSOANP00000030904	ENSOANP00000007758	Uncharacterized protein.	DBF4-type domain-containing protein.	0.588
CDC45	F6TS55_ORNAN	ENSOANP00000030904	ENSOANP00000015143	Uncharacterized protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.886
CDC45	F7AR20_ORNAN	ENSOANP00000030904	ENSOANP00000006992	Uncharacterized protein.	Uncharacterized protein.	0.588
CDC45	F7E3J1_ORNAN	ENSOANP00000030904	ENSOANP00000021918	Uncharacterized protein.	CDT1 domain-containing protein.	0.748
CDC45	K7ECA8_ORNAN	ENSOANP00000030904	ENSOANP00000031165	Uncharacterized protein.	Uncharacterized protein.	0.755
CDC45	K7ED41_ORNAN	ENSOANP00000030904	ENSOANP00000031448	Uncharacterized protein.	Cdc6_C domain-containing protein.	0.714
CDC45	MCM10	ENSOANP00000030904	ENSOANP00000000324	Uncharacterized protein.	Minichromosome maintenance 10 replication initiation factor.	0.933
CDC45	MCM2	ENSOANP00000030904	ENSOANP00000011401	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.994
CDC45	MCM3	ENSOANP00000030904	ENSOANP00000030803	Uncharacterized protein.	MCM_OB domain-containing protein.	0.991
CDC45	MCM4	ENSOANP00000030904	ENSOANP00000011566	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.997
CDC45	MCM5	ENSOANP00000030904	ENSOANP00000017224	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.931
CDC45	MCM6	ENSOANP00000030904	ENSOANP00000012709	Uncharacterized protein.	MCM domain-containing protein; Belongs to the MCM family.	0.987
CDC45	MCM8	ENSOANP00000030904	ENSOANP00000013356	Uncharacterized protein.	MCM domain-containing protein; Belongs to the MCM family.	0.786
CDC45	MCM9	ENSOANP00000030904	ENSOANP00000014030	Uncharacterized protein.	Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family.	0.799
CDC45	ORC2	ENSOANP00000030904	ENSOANP00000016003	Uncharacterized protein.	Origin recognition complex subunit 2.	0.755
CDC45	ORC3	ENSOANP00000030904	ENSOANP00000000855	Uncharacterized protein.	Origin recognition complex subunit 3.	0.763
CDC45	ORC4	ENSOANP00000030904	ENSOANP00000013319	Uncharacterized protein.	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.	0.714
CDC45	ORC5	ENSOANP00000030904	ENSOANP00000023674	Uncharacterized protein.	Origin recognition complex subunit 5.	0.804