STRINGSTRING
LTO1 LTO1 K7EI32_ORNAN K7EI32_ORNAN RUVBL2 RUVBL2 K7EHV5_ORNAN K7EHV5_ORNAN K7EHS6_ORNAN K7EHS6_ORNAN TEP1 TEP1 K7EH22_ORNAN K7EH22_ORNAN K7EGM5_ORNAN K7EGM5_ORNAN RIF1 RIF1 K7EFE3_ORNAN K7EFE3_ORNAN K7EF63_ORNAN K7EF63_ORNAN K7EF33_ORNAN K7EF33_ORNAN K7EEM2_ORNAN K7EEM2_ORNAN INO80 INO80 ACD ACD K7EBR3_ORNAN K7EBR3_ORNAN K7EAL5_ORNAN K7EAL5_ORNAN K7EA92_ORNAN K7EA92_ORNAN K7E9X2_ORNAN K7E9X2_ORNAN K7E960_ORNAN K7E960_ORNAN TELO2 TELO2 K7E8M8_ORNAN K7E8M8_ORNAN K7E8C1_ORNAN K7E8C1_ORNAN TINF2 TINF2 K7E7U9_ORNAN K7E7U9_ORNAN K7E7M8_ORNAN K7E7M8_ORNAN XRCC5 XRCC5 K7E739_ORNAN K7E739_ORNAN K7E6R8_ORNAN K7E6R8_ORNAN K7E6M7_ORNAN K7E6M7_ORNAN F6Y3L2_ORNAN F6Y3L2_ORNAN F6ZIG6_ORNAN F6ZIG6_ORNAN PINX1 PINX1 GAR1 GAR1 NSMCE2 NSMCE2 HUS1 HUS1 ERCC4 ERCC4 F7BR51_ORNAN F7BR51_ORNAN F7BRC7_ORNAN F7BRC7_ORNAN F7BS27_ORNAN F7BS27_ORNAN F7EMV0_ORNAN F7EMV0_ORNAN F7EMV6_ORNAN F7EMV6_ORNAN F7EMW0_ORNAN F7EMW0_ORNAN F7FYD7_ORNAN F7FYD7_ORNAN F7B8L0_ORNAN F7B8L0_ORNAN BRCA2 BRCA2 DCLRE1C DCLRE1C DNA2 DNA2 TERT TERT CCNE1 CCNE1 MCRS1 MCRS1 INO80D INO80D ATR ATR F7D8W7_ORNAN F7D8W7_ORNAN FBXO4 FBXO4 ZBTB48 ZBTB48 F6S2J0_ORNAN F6S2J0_ORNAN XRCC6 XRCC6 RPA1 RPA1 F6Y2M2_ORNAN F6Y2M2_ORNAN SMC6 SMC6 MRE11 MRE11 INO80E INO80E SLX4 SLX4 TFPT TFPT BLM BLM F7EIW2_ORNAN F7EIW2_ORNAN RAD51 RAD51 RUVBL1 RUVBL1 F7F2Y2_ORNAN F7F2Y2_ORNAN APEX1 APEX1 DKC1 DKC1 RAD51C RAD51C TERF2IP TERF2IP RAD50 RAD50 ACTR8 ACTR8 ENSOANP00000012261 ENSOANP00000012261 PRKDC PRKDC F7CL47_ORNAN F7CL47_ORNAN F6PRV0_ORNAN F6PRV0_ORNAN ZNF827 ZNF827 ATM ATM F7BUB6_ORNAN F7BUB6_ORNAN WRN WRN SMC5 SMC5 UPF1 UPF1 ERCC1 ERCC1 F7FJ30_ORNAN F7FJ30_ORNAN RECQL4 RECQL4 DCLRE1B DCLRE1B UCHL5 UCHL5 TERF2 TERF2 CCNE2 CCNE2 F6SUV9_ORNAN F6SUV9_ORNAN NOP10 NOP10 STN1 STN1 DCLRE1A DCLRE1A PARP1 PARP1 NBN NBN F6YDS3_ORNAN F6YDS3_ORNAN PIF1 PIF1 XRCC3 XRCC3 NFRKB NFRKB POT1 POT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LTO1LTO1 maturation factor of ABCE1. (121 aa)
K7EI32_ORNANUncharacterized protein. (129 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (103 aa)
K7EHV5_ORNANUncharacterized protein. (251 aa)
K7EHS6_ORNANFAT domain-containing protein. (138 aa)
TEP1TROVE domain-containing protein. (212 aa)
K7EH22_ORNANUncharacterized protein. (142 aa)
K7EGM5_ORNANFHA domain-containing protein. (142 aa)
RIF1Uncharacterized protein. (89 aa)
K7EFE3_ORNANWGR domain-containing protein. (180 aa)
K7EF63_ORNANTower domain-containing protein. (94 aa)
K7EF33_ORNANUncharacterized protein. (95 aa)
K7EEM2_ORNANUncharacterized protein. (75 aa)
INO80Uncharacterized protein. (97 aa)
ACDUncharacterized protein. (214 aa)
K7EBR3_ORNANUncharacterized protein. (127 aa)
K7EAL5_ORNANFAT domain-containing protein. (153 aa)
K7EA92_ORNANFAT domain-containing protein. (108 aa)
K7E9X2_ORNANUncharacterized protein. (110 aa)
K7E960_ORNANUncharacterized protein. (152 aa)
TELO2Uncharacterized protein. (234 aa)
K7E8M8_ORNANRECA_2 domain-containing protein. (216 aa)
K7E8C1_ORNANUncharacterized protein. (85 aa)
TINF2Uncharacterized protein. (237 aa)
K7E7U9_ORNANPI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (77 aa)
K7E7M8_ORNANUncharacterized protein. (181 aa)
XRCC5Ku_N domain-containing protein. (88 aa)
K7E739_ORNANUME domain-containing protein. (306 aa)
K7E6R8_ORNANUncharacterized protein. (107 aa)
K7E6M7_ORNANUncharacterized protein. (389 aa)
F6Y3L2_ORNANUncharacterized protein; Belongs to the CGI121/TPRKB family. (147 aa)
F6ZIG6_ORNANPUA domain-containing protein. (354 aa)
PINX1Uncharacterized protein. (222 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (223 aa)
NSMCE2SP-RING-type domain-containing protein. (91 aa)
HUS1Uncharacterized protein. (91 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (807 aa)
F7BR51_ORNANNbs1_C domain-containing protein. (284 aa)
F7BRC7_ORNANProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (214 aa)
F7BS27_ORNANUncharacterized protein. (122 aa)
F7EMV0_ORNANTAN domain-containing protein. (121 aa)
F7EMV6_ORNANTAN domain-containing protein. (316 aa)
F7EMW0_ORNANUncharacterized protein. (86 aa)
F7FYD7_ORNANUncharacterized protein. (519 aa)
F7B8L0_ORNANUncharacterized protein. (742 aa)
BRCA2Tower domain-containing protein. (3459 aa)
DCLRE1CDNA cross-link repair 1C. (700 aa)
DNA2Uncharacterized protein. (567 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1101 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (423 aa)
MCRS1MCRS_N domain-containing protein. (249 aa)
INO80DINO80 complex subunit D. (1036 aa)
ATRUncharacterized protein. (473 aa)
F7D8W7_ORNANUncharacterized protein. (2295 aa)
FBXO4F-box domain-containing protein. (260 aa)
ZBTB48Zinc finger and BTB domain containing 48. (685 aa)
F6S2J0_ORNANUncharacterized protein. (194 aa)
XRCC6SAP domain-containing protein. (414 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
F6Y2M2_ORNANBRCT domain-containing protein. (449 aa)
SMC6Uncharacterized protein. (603 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (624 aa)
INO80EINO80 complex subunit E. (236 aa)
SLX4Uncharacterized protein. (1178 aa)
TFPTTCF3 fusion partner. (259 aa)
BLMATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (769 aa)
F7EIW2_ORNANKu_N domain-containing protein. (204 aa)
RAD51Uncharacterized protein. (119 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (396 aa)
F7F2Y2_ORNANWD_REPEATS_REGION domain-containing protein. (263 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (403 aa)
DKC1PUA domain-containing protein. (485 aa)
RAD51CRAD51 paralog C. (458 aa)
TERF2IPTERF2 interacting protein. (407 aa)
RAD50Zinc-hook domain-containing protein. (1209 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (513 aa)
ENSOANP00000012261annotation not available (55 aa)
PRKDCFAT domain-containing protein. (3522 aa)
F7CL47_ORNANUncharacterized protein. (92 aa)
F6PRV0_ORNANPI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (171 aa)
ZNF827Zinc finger protein 827. (1211 aa)
ATMFAT domain-containing protein. (1029 aa)
F7BUB6_ORNANRif1_N domain-containing protein. (2379 aa)
WRNWRN RecQ like helicase. (1333 aa)
SMC5SMC_N domain-containing protein. (1101 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
ERCC1Uncharacterized protein. (310 aa)
F7FJ30_ORNANUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1020 aa)
RECQL4RecQ like helicase 4. (1188 aa)
DCLRE1BDNA cross-link repair 1B. (563 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (259 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (386 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
F6SUV9_ORNANSMC_N domain-containing protein. (340 aa)
NOP10Uncharacterized protein. (55 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (370 aa)
DCLRE1ADNA cross-link repair 1A. (1006 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
NBNUncharacterized protein. (396 aa)
F6YDS3_ORNANTelomere_reg-2 domain-containing protein. (563 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (634 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa)
NFRKBNuclear factor related to kappaB binding protein. (1321 aa)
POT1Protection of telomeres 1. (855 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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