STRINGSTRING
RAD51C RAD51C F7CQ71_ORNAN F7CQ71_ORNAN RNF138 RNF138 F7BXU5_ORNAN F7BXU5_ORNAN WRN WRN EPC1 EPC1 XRCC2 XRCC2 PSMD14 PSMD14 ATM ATM GINS4 GINS4 MCM9-2 MCM9-2 MCM2 MCM2 SPIDR SPIDR MCM4 MCM4 F6XVG2_ORNAN F6XVG2_ORNAN POLL POLL F6W8Y9_ORNAN F6W8Y9_ORNAN MCM6 MCM6 F7EW15_ORNAN F7EW15_ORNAN MCM8 MCM8 CRLS1 CRLS1 MCM9 MCM9 RBBP8 RBBP8 NIPBL NIPBL RAD51 RAD51 BLM BLM SLX4 SLX4 SAMHD1 SAMHD1 WDR48 WDR48 TOP3A TOP3A REV3L REV3L F6ZQP9_ORNAN F6ZQP9_ORNAN FAN1 FAN1 MRE11 MRE11 DMC1 DMC1 SMC6 SMC6 F6Y2M2_ORNAN F6Y2M2_ORNAN MCM5 MCM5 RPA1 RPA1 RMI1 RMI1 NSMCE1 NSMCE1 F7FCF8_ORNAN F7FCF8_ORNAN RAD54B RAD54B GINS2 GINS2 F6S2J0_ORNAN F6S2J0_ORNAN F7FVF8_ORNAN F7FVF8_ORNAN SEM1 SEM1 EXD2 EXD2 ZSWIM7 ZSWIM7 RFWD3 RFWD3 F6S822_ORNAN F6S822_ORNAN RAD52 RAD52 FANCM FANCM F7G4U4_ORNAN F7G4U4_ORNAN CDC7 CDC7 F6PTS2_ORNAN F6PTS2_ORNAN SWI5 SWI5 FBH1 FBH1 BRCA2 BRCA2 F7FYD7_ORNAN F7FYD7_ORNAN F7EMW0_ORNAN F7EMW0_ORNAN F7EMV6_ORNAN F7EMV6_ORNAN F7EMV0_ORNAN F7EMV0_ORNAN RECQL5 RECQL5 F7BS27_ORNAN F7BS27_ORNAN F7BR51_ORNAN F7BR51_ORNAN ERCC4 ERCC4 HUS1 HUS1 NSMCE2 NSMCE2 F6QAF0_ORNAN F6QAF0_ORNAN F7G0R7_ORNAN F7G0R7_ORNAN F6TT55_ORNAN F6TT55_ORNAN F6Z0X4_ORNAN F6Z0X4_ORNAN NABP1 NABP1 F6TKG8_ORNAN F6TKG8_ORNAN K7EDU9_ORNAN K7EDU9_ORNAN MUS81 MUS81 K7EEP5_ORNAN K7EEP5_ORNAN K7EF63_ORNAN K7EF63_ORNAN K7EFA8_ORNAN K7EFA8_ORNAN INTS3 INTS3 GEN1 GEN1 K7EGM5_ORNAN K7EGM5_ORNAN NUCKS1 NUCKS1 K7EHV5_ORNAN K7EHV5_ORNAN ENSOANP00000033155 ENSOANP00000033155 F6U4G4_ORNAN F6U4G4_ORNAN ENSOANP00000029145 ENSOANP00000029145 K7E764_ORNAN K7E764_ORNAN K7E7G1_ORNAN K7E7G1_ORNAN K7E7U9_ORNAN K7E7U9_ORNAN K7E8C1_ORNAN K7E8C1_ORNAN K7E8J2_ORNAN K7E8J2_ORNAN K7E8M8_ORNAN K7E8M8_ORNAN K7E960_ORNAN K7E960_ORNAN K7E9A0_ORNAN K7E9A0_ORNAN K7E9F1_ORNAN K7E9F1_ORNAN K7E9X2_ORNAN K7E9X2_ORNAN K7EA92_ORNAN K7EA92_ORNAN K7EAF2_ORNAN K7EAF2_ORNAN K7EAK1_ORNAN K7EAK1_ORNAN K7EAL5_ORNAN K7EAL5_ORNAN K7EAM9_ORNAN K7EAM9_ORNAN K7EAP7_ORNAN K7EAP7_ORNAN MCM3 MCM3 CDC45 CDC45 BRCA1 BRCA1 RAD54L RAD54L K7ECT5_ORNAN K7ECT5_ORNAN INO80 INO80 K7ED11_ORNAN K7ED11_ORNAN K7ED80_ORNAN K7ED80_ORNAN F7EMZ8_ORNAN F7EMZ8_ORNAN F6YM44_ORNAN F6YM44_ORNAN XRCC3 XRCC3 INIP INIP MMS22L MMS22L NBN NBN HELQ HELQ F6SUV9_ORNAN F6SUV9_ORNAN MCMDC2 MCMDC2 F7BB16_ORNAN F7BB16_ORNAN TONSL TONSL EXD2-2 EXD2-2 FANCB FANCB MEIOB MEIOB F6SF21_ORNAN F6SF21_ORNAN ZFYVE26 ZFYVE26 MBTD1 MBTD1 AP5Z1 AP5Z1 RECQL4 RECQL4 F6S2Y0_ORNAN F6S2Y0_ORNAN SWSAP1 SWSAP1 RAD21 RAD21 SMC5 SMC5 F7CRP1_ORNAN F7CRP1_ORNAN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD51CRAD51 paralog C. (458 aa)
F7CQ71_ORNANDNA_pol_B domain-containing protein. (151 aa)
RNF138Ring finger protein 138. (199 aa)
F7BXU5_ORNANUncharacterized protein. (222 aa)
WRNWRN RecQ like helicase. (1333 aa)
EPC1Enhancer of polycomb homolog. (813 aa)
XRCC2X-ray repair cross complementing 2. (278 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
ATMFAT domain-containing protein. (1029 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (225 aa)
MCM9-2Uncharacterized protein. (46 aa)
MCM2DNA helicase; Belongs to the MCM family. (908 aa)
SPIDRDUF4503 domain-containing protein. (557 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
F6XVG2_ORNANAAA_23 domain-containing protein. (170 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (522 aa)
F6W8Y9_ORNANPALB2_WD40 domain-containing protein. (1194 aa)
MCM6MCM domain-containing protein; Belongs to the MCM family. (741 aa)
F7EW15_ORNANXPGI domain-containing protein. (807 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (828 aa)
CRLS1Cardiolipin synthase 1. (203 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1137 aa)
RBBP8Uncharacterized protein. (569 aa)
NIPBLNipped-B protein. (2821 aa)
RAD51Uncharacterized protein. (119 aa)
BLMATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (769 aa)
SLX4Uncharacterized protein. (1178 aa)
SAMHD1HD domain-containing protein. (141 aa)
WDR48WD repeat domain 48. (662 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (940 aa)
REV3LUncharacterized protein. (551 aa)
F6ZQP9_ORNANDUF4683 domain-containing protein. (360 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1036 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (624 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (333 aa)
SMC6Uncharacterized protein. (603 aa)
F6Y2M2_ORNANBRCT domain-containing protein. (449 aa)
MCM5DNA helicase; Belongs to the MCM family. (609 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
RMI1RecQ mediated genome instability 1. (612 aa)
NSMCE1Uncharacterized protein. (199 aa)
F7FCF8_ORNANUncharacterized protein. (688 aa)
RAD54BUncharacterized protein. (753 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (155 aa)
F6S2J0_ORNANUncharacterized protein. (194 aa)
F7FVF8_ORNANUncharacterized protein. (80 aa)
SEM1Uncharacterized protein. (70 aa)
EXD2Exonuclease 3'-5' domain containing 2. (498 aa)
ZSWIM7Zinc finger SWIM-type containing 7. (139 aa)
RFWD3RING-type domain-containing protein. (744 aa)
F6S822_ORNANUncharacterized protein. (279 aa)
RAD52Uncharacterized protein. (95 aa)
FANCMUncharacterized protein. (1951 aa)
F7G4U4_ORNANLEM domain-containing protein. (286 aa)
CDC7Cell division cycle 7; Belongs to the protein kinase superfamily. (410 aa)
F6PTS2_ORNANUncharacterized protein. (458 aa)
SWI5Uncharacterized protein. (89 aa)
FBH1F-box DNA helicase 1. (1035 aa)
BRCA2Tower domain-containing protein. (3459 aa)
F7FYD7_ORNANUncharacterized protein. (519 aa)
F7EMW0_ORNANUncharacterized protein. (86 aa)
F7EMV6_ORNANTAN domain-containing protein. (316 aa)
F7EMV0_ORNANTAN domain-containing protein. (121 aa)
RECQL5Uncharacterized protein. (413 aa)
F7BS27_ORNANUncharacterized protein. (122 aa)
F7BR51_ORNANNbs1_C domain-containing protein. (284 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (807 aa)
HUS1Uncharacterized protein. (91 aa)
NSMCE2SP-RING-type domain-containing protein. (91 aa)
F6QAF0_ORNANRad21_Rec8 domain-containing protein. (356 aa)
F7G0R7_ORNANUncharacterized protein. (377 aa)
F6TT55_ORNANUncharacterized protein. (114 aa)
F6Z0X4_ORNANRAD51_interact domain-containing protein. (922 aa)
NABP1Nucleic acid binding protein 1. (126 aa)
F6TKG8_ORNANHelicase C-terminal domain-containing protein. (345 aa)
K7EDU9_ORNANERCC4 domain-containing protein. (133 aa)
MUS81Uncharacterized protein. (135 aa)
K7EEP5_ORNANUncharacterized protein. (88 aa)
K7EF63_ORNANTower domain-containing protein. (94 aa)
K7EFA8_ORNANUncharacterized protein. (359 aa)
INTS3Uncharacterized protein. (66 aa)
GEN1Uncharacterized protein. (132 aa)
K7EGM5_ORNANFHA domain-containing protein. (142 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (295 aa)
K7EHV5_ORNANUncharacterized protein. (251 aa)
ENSOANP00000033155annotation not available (86 aa)
F6U4G4_ORNANKASH_CCD domain-containing protein. (361 aa)
ENSOANP00000029145annotation not available (79 aa)
K7E764_ORNANUncharacterized protein. (240 aa)
K7E7G1_ORNANUncharacterized protein. (684 aa)
K7E7U9_ORNANPI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (77 aa)
K7E8C1_ORNANUncharacterized protein. (85 aa)
K7E8J2_ORNANUncharacterized protein. (75 aa)
K7E8M8_ORNANRECA_2 domain-containing protein. (216 aa)
K7E960_ORNANUncharacterized protein. (152 aa)
K7E9A0_ORNANUncharacterized protein. (167 aa)
K7E9F1_ORNANRING-type domain-containing protein. (145 aa)
K7E9X2_ORNANUncharacterized protein. (110 aa)
K7EA92_ORNANFAT domain-containing protein. (108 aa)
K7EAF2_ORNANSAE2 domain-containing protein. (183 aa)
K7EAK1_ORNANUncharacterized protein. (170 aa)
K7EAL5_ORNANFAT domain-containing protein. (153 aa)
K7EAM9_ORNANUncharacterized protein. (93 aa)
K7EAP7_ORNANUncharacterized protein. (241 aa)
MCM3MCM_OB domain-containing protein. (192 aa)
CDC45Uncharacterized protein. (146 aa)
BRCA1Uncharacterized protein. (208 aa)
RAD54LSNF2_N domain-containing protein. (294 aa)
K7ECT5_ORNANUncharacterized protein. (70 aa)
INO80Uncharacterized protein. (97 aa)
K7ED11_ORNANUncharacterized protein. (118 aa)
K7ED80_ORNANCtIP_N domain-containing protein. (108 aa)
F7EMZ8_ORNANDNA_pol_B_exo1 domain-containing protein. (225 aa)
F6YM44_ORNANUncharacterized protein. (579 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa)
INIPINTS3 and NABP interacting protein. (88 aa)
MMS22LMMS22 like, DNA repair protein. (1253 aa)
NBNUncharacterized protein. (396 aa)
HELQUncharacterized protein. (727 aa)
F6SUV9_ORNANSMC_N domain-containing protein. (340 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
F7BB16_ORNANATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (444 aa)
TONSLUncharacterized protein. (413 aa)
EXD2-2Uncharacterized protein. (128 aa)
FANCBUncharacterized protein. (868 aa)
MEIOBMeiosis specific with OB-fold. (472 aa)
F6SF21_ORNANUncharacterized protein. (201 aa)
ZFYVE26FYVE-type domain-containing protein. (652 aa)
MBTD1Mbt domain containing 1. (605 aa)
AP5Z1Uncharacterized protein. (648 aa)
RECQL4RecQ like helicase 4. (1188 aa)
F6S2Y0_ORNANUncharacterized protein. (58 aa)
SWSAP1Uncharacterized protein. (181 aa)
RAD21Uncharacterized protein. (689 aa)
SMC5SMC_N domain-containing protein. (1101 aa)
F7CRP1_ORNANDNA_pol_B domain-containing protein. (83 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
Server load: low (22%) [HD]