(26 nodes) Endothelial cell proliferation network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F7CVB0_ORNAN	Uncharacterized protein. (408 aa)
	THAP1	THAP domain containing 1. (223 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	PROK1	Prokineticin 1. (105 aa)
	PRKX	Uncharacterized protein. (347 aa)
	F6PVL6_ORNAN	Uncharacterized protein. (918 aa)
	BMPER	Uncharacterized protein. (507 aa)
	F6W205_ORNAN	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	ERN1	Endoplasmic reticulum to nucleus signaling 1. (900 aa)
	XBP1	X-box binding protein 1. (190 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (99 aa)
	VSTM4	Ig-like domain-containing protein. (173 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1031 aa)
	NOX5	NADPH oxidase 5. (659 aa)
	TEK	TEK receptor tyrosine kinase. (1000 aa)
	LOXL2	Lysyl oxidase like 2. (779 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	TGFBR1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (438 aa)
	EPHA2	EPH receptor A2. (973 aa)
	CAV1	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (113 aa)
	ENSOANP00000023661	annotation not available (113 aa)
	F6SU31_ORNAN	Uncharacterized protein. (116 aa)
	NF1	Ras-GAP domain-containing protein. (1467 aa)
	ERN1-2	Uncharacterized protein. (67 aa)
	K7EFP4_ORNAN	Uncharacterized protein. (71 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPER	BMPR2	ENSOANP00000009344	ENSOANP00000019463	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.535
BMPR2	BMPER	ENSOANP00000019463	ENSOANP00000009344	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Uncharacterized protein.	0.535
BMPR2	CAV1	ENSOANP00000019463	ENSOANP00000023660	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.426
BMPR2	TGFBR1	ENSOANP00000019463	ENSOANP00000023412	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.639
CAV1	BMPR2	ENSOANP00000023660	ENSOANP00000019463	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.426
CAV1	F6W205_ORNAN	ENSOANP00000023660	ENSOANP00000009374	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.991
CAV1	SCARB1	ENSOANP00000023660	ENSOANP00000002110	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.516
CAV1	TGFBR1	ENSOANP00000023660	ENSOANP00000023412	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.473
ENSOANP00000023661	F6W205_ORNAN	ENSOANP00000023661	ENSOANP00000009374	annotation not available	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.919
ENSOANP00000023661	SCARB1	ENSOANP00000023661	ENSOANP00000002110	annotation not available	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.516
ENSOANP00000023661	TGFBR1	ENSOANP00000023661	ENSOANP00000023412	annotation not available	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.473
EPHA2	FGF7	ENSOANP00000023610	ENSOANP00000015581	EPH receptor A2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.673
EPHA2	SCARB1	ENSOANP00000023610	ENSOANP00000002110	EPH receptor A2.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.583
ERN1	XBP1	ENSOANP00000012776	ENSOANP00000014046	Endoplasmic reticulum to nucleus signaling 1.	X-box binding protein 1.	0.592
ERN1-2	XBP1	ENSOANP00000030549	ENSOANP00000014046	Uncharacterized protein.	X-box binding protein 1.	0.957
F6PVL6_ORNAN	NF1	ENSOANP00000009021	ENSOANP00000027864	Uncharacterized protein.	Ras-GAP domain-containing protein.	0.951
F6SU31_ORNAN	VSTM4	ENSOANP00000027509	ENSOANP00000018706	Uncharacterized protein.	Ig-like domain-containing protein.	0.922
F6W205_ORNAN	CAV1	ENSOANP00000009374	ENSOANP00000023660	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...]	0.991
F6W205_ORNAN	ENSOANP00000023661	ENSOANP00000009374	ENSOANP00000023661	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	annotation not available	0.919
FGF7	EPHA2	ENSOANP00000015581	ENSOANP00000023610	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	EPH receptor A2.	0.673