STRINGSTRING
QTRT2 QTRT2 THADA THADA TRIT1 TRIT1 TRMO TRMO F7FL51_ORNAN F7FL51_ORNAN TYW3 TYW3 F7ALK5_ORNAN F7ALK5_ORNAN TRMT11 TRMT11 TYW5 TYW5 YRDC YRDC TRMU TRMU ALKBH8 ALKBH8 AARS1 AARS1 TRMT1L TRMT1L METTL2A METTL2A TRMT10B TRMT10B TRMT61A TRMT61A HSD17B10 HSD17B10 NSUN2 NSUN2 CTU2 CTU2 ELP1 ELP1 TRMT12 TRMT12 ELP2 ELP2 DTWD1 DTWD1 TRUB1 TRUB1 PUS1 PUS1 F6YNQ5_ORNAN F6YNQ5_ORNAN CTU1 CTU1 ALKBH1 ALKBH1 CX5H9orf64 CX5H9orf64 F6ZLR8_ORNAN F6ZLR8_ORNAN WDR6 WDR6 CDKAL1 CDKAL1 TRMT13 TRMT13 F7FWI6_ORNAN F7FWI6_ORNAN NSUN3 NSUN3 GTPBP3 GTPBP3 F6PGE7_ORNAN F6PGE7_ORNAN F6XB74_ORNAN F6XB74_ORNAN GTPBP6 GTPBP6 THUMPD1 THUMPD1 METTL1 METTL1 F7BD68_ORNAN F7BD68_ORNAN THUMPD3 THUMPD3 F6W0H7_ORNAN F6W0H7_ORNAN ANKRD16 ANKRD16 ELP6 ELP6 DUS4L DUS4L TRMT44 TRMT44 F7G298_ORNAN F7G298_ORNAN ADAT2 ADAT2 F7ES32_ORNAN F7ES32_ORNAN BCDIN3D BCDIN3D DTWD2 DTWD2 F6Y3L2_ORNAN F6Y3L2_ORNAN F6Y244_ORNAN F6Y244_ORNAN ELP3 ELP3 QTRT1 QTRT1 PUS3 PUS3 TRMT1 TRMT1 CDK5RAP1 CDK5RAP1 DUS2 DUS2 K7ECX0_ORNAN K7ECX0_ORNAN K7EDI1_ORNAN K7EDI1_ORNAN K7EDZ0_ORNAN K7EDZ0_ORNAN K7EEA1_ORNAN K7EEA1_ORNAN PUS10 PUS10 LYRM9 LYRM9 K7EGD5_ORNAN K7EGD5_ORNAN K7EGH0_ORNAN K7EGH0_ORNAN MTFMT MTFMT K7EHB1_ORNAN K7EHB1_ORNAN OSGEP OSGEP MOCS3 MOCS3 METTL8 METTL8 TRMT6 TRMT6 TYW1 TYW1 TRMT10C TRMT10C NAT10 NAT10 RPUSD4 RPUSD4 TRMT10A TRMT10A F7CX02_ORNAN F7CX02_ORNAN F7C3Q2_ORNAN F7C3Q2_ORNAN METTL6 METTL6 WDR4 WDR4 NSUN6 NSUN6 THG1L THG1L F7FHV0_ORNAN F7FHV0_ORNAN DUS3L DUS3L TRMT2B TRMT2B DALRD3 DALRD3 THUMPD2 THUMPD2 URM1 URM1 MTO1 MTO1 F6SN38_ORNAN F6SN38_ORNAN PUS7 PUS7
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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QTRT2Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (466 aa)
THADADUF2428 domain-containing protein. (697 aa)
TRIT1tRNA isopentenyltransferase 1; Belongs to the IPP transferase family. (393 aa)
TRMOtRNA methyltransferase O. (407 aa)
F7FL51_ORNANFormyl_trans_N domain-containing protein. (177 aa)
TYW3TYW3 domain-containing protein. (198 aa)
F7ALK5_ORNANMethyltransf_11 domain-containing protein. (325 aa)
TRMT11tRNA methyltransferase 11 homolog. (461 aa)
TYW5JmjC domain-containing protein. (176 aa)
YRDCYrdC-like domain-containing protein. (128 aa)
TRMUtRNA 5-methylaminomethyl-2-thiouridylate methyltransferase. (394 aa)
ALKBH8AlkB homolog 8, tRNA methyltransferase. (666 aa)
AARS1Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
TRMT1LtRNA (guanine(26)-N(2))-dimethyltransferase. (653 aa)
METTL2AMethyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (377 aa)
TRMT10BtRNA methyltransferase 10B. (333 aa)
TRMT61AUncharacterized protein. (193 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (197 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (742 aa)
CTU2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the CTU2/NCS2 family. (507 aa)
ELP1Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1339 aa)
TRMT12tRNA methyltransferase 12 homolog. (410 aa)
ELP2Elongator acetyltransferase complex subunit 2. (830 aa)
DTWD1DTW domain containing 1. (321 aa)
TRUB1TruB pseudouridine synthase family member 1. (303 aa)
PUS1Pseudouridine synthase 1. (436 aa)
F6YNQ5_ORNANUncharacterized protein. (73 aa)
CTU1Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position; Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily. (329 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (365 aa)
CX5H9orf64Queuosine salvage protein; Involved in salvaging queuosine. (278 aa)
F6ZLR8_ORNANUncharacterized protein. (192 aa)
WDR6WD_REPEATS_REGION domain-containing protein. (1134 aa)
CDKAL1CDK5 regulatory subunit associated protein 1 like 1. (424 aa)
TRMT13tRNA methyltransferase 13 homolog. (434 aa)
F7FWI6_ORNANFtsJ domain-containing protein. (240 aa)
NSUN3SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (127 aa)
GTPBP3GTP binding protein 3, mitochondrial. (522 aa)
F6PGE7_ORNANUncharacterized protein. (177 aa)
F6XB74_ORNANUncharacterized protein. (772 aa)
GTPBP6Hflx-type G domain-containing protein. (193 aa)
THUMPD1THUMP domain containing 1. (352 aa)
METTL1tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (245 aa)
F7BD68_ORNANUncharacterized protein. (434 aa)
THUMPD3THUMP domain containing 3. (425 aa)
F6W0H7_ORNANUncharacterized protein. (226 aa)
ANKRD16Ankyrin repeat domain 16. (382 aa)
ELP6Elongator acetyltransferase complex subunit 6. (261 aa)
DUS4LtRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family. (307 aa)
TRMT44Uncharacterized protein. (200 aa)
F7G298_ORNANUncharacterized protein. (149 aa)
ADAT2CMP/dCMP-type deaminase domain-containing protein. (122 aa)
F7ES32_ORNANAA_TRNA_LIGASE_II_ALA domain-containing protein. (504 aa)
BCDIN3DBCDIN3 domain containing RNA methyltransferase. (304 aa)
DTWD2DTW domain-containing protein. (182 aa)
F6Y3L2_ORNANUncharacterized protein; Belongs to the CGI121/TPRKB family. (147 aa)
F6Y244_ORNANUncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (353 aa)
ELP3Radical_SAM_C domain-containing protein. (250 aa)
QTRT1TGT domain-containing protein. (101 aa)
PUS3Pseudouridine synthase 3. (504 aa)
TRMT1Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (120 aa)
CDK5RAP1Radical_SAM domain-containing protein. (125 aa)
DUS2DRBM domain-containing protein. (203 aa)
K7ECX0_ORNANPeptidase_M22 domain-containing protein. (266 aa)
K7EDI1_ORNANUncharacterized protein. (654 aa)
K7EDZ0_ORNANTGT domain-containing protein. (103 aa)
K7EEA1_ORNANYrdC-like domain-containing protein. (137 aa)
PUS10Pseudouridine synthase 10. (560 aa)
LYRM9Uncharacterized protein; Belongs to the complex I LYR family. (78 aa)
K7EGD5_ORNANUncharacterized protein. (90 aa)
K7EGH0_ORNANHelicase_RecD domain-containing protein. (118 aa)
MTFMTFormyl_trans_C domain-containing protein. (220 aa)
K7EHB1_ORNANDUF1726 domain-containing protein. (66 aa)
OSGEPO-sialoglycoprotein endopeptidase. (260 aa)
MOCS3ThiF domain-containing protein. (237 aa)
METTL8Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (379 aa)
TRMT6tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (451 aa)
TYW1Uncharacterized protein. (323 aa)
TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit. (371 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (990 aa)
RPUSD4RNA pseudouridine synthase D4. (313 aa)
TRMT10AtRNA methyltransferase 10A. (314 aa)
F7CX02_ORNANUncharacterized protein. (466 aa)
F7C3Q2_ORNANQueuosine salvage protein; Involved in salvaging queuosine. (74 aa)
METTL6Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (279 aa)
WDR4tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (389 aa)
NSUN6NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (476 aa)
THG1LtRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (300 aa)
F7FHV0_ORNANUncharacterized protein. (956 aa)
DUS3LtRNA-dihydrouridine(47) synthase [NAD(P)(+)]. (668 aa)
TRMT2BtRNA methyltransferase 2 homolog B; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (487 aa)
DALRD3DALR_1 domain-containing protein. (163 aa)
THUMPD2THUMP domain-containing protein. (368 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for co [...] (97 aa)
MTO1Mitochondrial tRNA translation optimization 1. (527 aa)
F6SN38_ORNANUncharacterized protein. (176 aa)
PUS7Pseudouridine synthase 7. (675 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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