(17 nodes) Multicellular organism aging network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EDN1	Endothelin 1. (204 aa)
	AVPR1B	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (173 aa)
	WRN	WRN RecQ like helicase. (1333 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	ERCC1	Uncharacterized protein. (310 aa)
	GNA12	G protein subunit alpha 12. (281 aa)
	K7E8C1_ORNAN	Uncharacterized protein. (85 aa)
	F6RKJ4_ORNAN	Uncharacterized protein. (86 aa)
	SEC63	SEC63 homolog, protein translocation regulator. (704 aa)
	F6PHG4_ORNAN	Uncharacterized protein; Belongs to the alkaline phosphatase family. (215 aa)
	GNA13	G protein subunit alpha 13. (291 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (677 aa)
	F7CLA4_ORNAN	RING-type domain-containing protein. (343 aa)
	ADRA1A	G_PROTEIN_RECEP_F1_2 domain-containing protein. (298 aa)
	AVPR1A	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (433 aa)
	F6UAA2_ORNAN	TSP C-terminal domain-containing protein. (277 aa)
	F6RT37_ORNAN	Uncharacterized protein. (175 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	EDN1	ENSOANP00000024921	ENSOANP00000011454	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Endothelin 1.	0.660
ADRA1A	F6RT37_ORNAN	ENSOANP00000024921	ENSOANP00000012069	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Uncharacterized protein.	0.899
ADRA1A	GNA12	ENSOANP00000024921	ENSOANP00000006862	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G protein subunit alpha 12.	0.958
ADRA1A	GNA13	ENSOANP00000024921	ENSOANP00000012823	G_PROTEIN_RECEP_F1_2 domain-containing protein.	G protein subunit alpha 13.	0.595
AVPR1A	AVPR1B	ENSOANP00000003311	ENSOANP00000010148	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.934
AVPR1A	EDN1	ENSOANP00000003311	ENSOANP00000011454	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Endothelin 1.	0.740
AVPR1A	GNA12	ENSOANP00000003311	ENSOANP00000006862	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	G protein subunit alpha 12.	0.914
AVPR1B	AVPR1A	ENSOANP00000010148	ENSOANP00000003311	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.934
AVPR1B	EDN1	ENSOANP00000010148	ENSOANP00000011454	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Endothelin 1.	0.734
AVPR1B	EDNRA	ENSOANP00000010148	ENSOANP00000008365	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.401
AVPR1B	GNA12	ENSOANP00000010148	ENSOANP00000006862	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	G protein subunit alpha 12.	0.914
EDN1	ADRA1A	ENSOANP00000011454	ENSOANP00000024921	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.660
EDN1	AVPR1A	ENSOANP00000011454	ENSOANP00000003311	Endothelin 1.	Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.740
EDN1	AVPR1B	ENSOANP00000011454	ENSOANP00000010148	Endothelin 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.734
EDN1	EDNRA	ENSOANP00000011454	ENSOANP00000008365	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.998
EDN1	F6RT37_ORNAN	ENSOANP00000011454	ENSOANP00000012069	Endothelin 1.	Uncharacterized protein.	0.567
EDNRA	AVPR1B	ENSOANP00000008365	ENSOANP00000010148	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.	0.401
EDNRA	EDN1	ENSOANP00000008365	ENSOANP00000011454	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.998
EDNRA	GNA12	ENSOANP00000008365	ENSOANP00000006862	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 12.	0.947
ERCC1	K7E8C1_ORNAN	ENSOANP00000007190	ENSOANP00000029778	Uncharacterized protein.	Uncharacterized protein.	0.549