(59 nodes) Response to gamma radiation network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KDM1A	Lysine demethylase 1A. (653 aa)
	F7A7F5_ORNAN	Cbl-PTB domain-containing protein. (212 aa)
	TLK2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (441 aa)
	HSF1	Heat shock transcription factor 1. (464 aa)
	F7F164_ORNAN	Uncharacterized protein. (264 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (973 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (224 aa)
	K7EHV5_ORNAN	Uncharacterized protein. (251 aa)
	K7EHS6_ORNAN	FAT domain-containing protein. (138 aa)
	K7EF63_ORNAN	Tower domain-containing protein. (94 aa)
	K7EF33_ORNAN	Uncharacterized protein. (95 aa)
	K7EF27_ORNAN	Uncharacterized protein. (228 aa)
	K7EEM2_ORNAN	Uncharacterized protein. (75 aa)
	K7EBA7_ORNAN	Uncharacterized protein. (110 aa)
	K7EAL5_ORNAN	FAT domain-containing protein. (153 aa)
	APOBEC1	Uncharacterized protein. (88 aa)
	K7EA92_ORNAN	FAT domain-containing protein. (108 aa)
	K7E9X2_ORNAN	Uncharacterized protein. (110 aa)
	K7E9G3_ORNAN	Uncharacterized protein. (168 aa)
	K7E960_ORNAN	Uncharacterized protein. (152 aa)
	K7E8C1_ORNAN	Uncharacterized protein. (85 aa)
	K7E7U9_ORNAN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (77 aa)
	K7E7M8_ORNAN	Uncharacterized protein. (181 aa)
	XRCC5	Ku_N domain-containing protein. (88 aa)
	K7E739_ORNAN	UME domain-containing protein. (306 aa)
	ERCC6	Uncharacterized protein. (375 aa)
	F6QIR6_ORNAN	Uncharacterized protein. (274 aa)
	F6TA56_ORNAN	Uncharacterized protein. (176 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (575 aa)
	F7F5D6_ORNAN	Uncharacterized protein. (277 aa)
	FANCD2	Uncharacterized protein. (338 aa)
	F7BN07_ORNAN	Tyrosine-protein phosphatase domain-containing protein. (196 aa)
	F6UYY9_ORNAN	Uncharacterized protein. (353 aa)
	F7EMV0_ORNAN	TAN domain-containing protein. (121 aa)
	F7EMV6_ORNAN	TAN domain-containing protein. (316 aa)
	F7EMW0_ORNAN	Uncharacterized protein. (86 aa)
	BRCA2	Tower domain-containing protein. (3459 aa)
	TIGAR	Uncharacterized protein. (195 aa)
	PTPRC	Uncharacterized protein. (548 aa)
	DCUN1D3	DCN1-like protein. (304 aa)
	MEN1	Uncharacterized protein. (113 aa)
	ATR	Uncharacterized protein. (473 aa)
	F6U411_ORNAN	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (462 aa)
	TP53	P53 domain-containing protein. (87 aa)
	XRCC6	SAP domain-containing protein. (414 aa)
	TMEM109	Uncharacterized protein. (269 aa)
	F6TTL2_ORNAN	Uncharacterized protein. (268 aa)
	F7EIW2_ORNAN	Ku_N domain-containing protein. (204 aa)
	PML	Uncharacterized protein. (331 aa)
	CHEK2	Checkpoint kinase 2. (553 aa)
	MAP3K20	Uncharacterized protein. (800 aa)
	MYC	BHLH domain-containing protein. (182 aa)
	F7G3Q8_ORNAN	Uncharacterized protein. (640 aa)
	GTF2H5	General transcription factor IIH subunit 5. (71 aa)
	CRYAB	AlphaB-crystallin; Belongs to the small heat shock protein (HSP20) family. (167 aa)
	ATM	FAT domain-containing protein. (1029 aa)
	XRCC2	X-ray repair cross complementing 2. (278 aa)
	WRN	WRN RecQ like helicase. (1333 aa)
	F7FJ30_ORNAN	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1020 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSOANP00000009993	ENSOANP00000020304	FAT domain-containing protein.	Uncharacterized protein.	0.947
ATM	BRCA2	ENSOANP00000009993	ENSOANP00000024376	FAT domain-containing protein.	Tower domain-containing protein.	0.780
ATM	CHEK2	ENSOANP00000009993	ENSOANP00000014054	FAT domain-containing protein.	Checkpoint kinase 2.	0.978
ATM	F7EIW2_ORNAN	ENSOANP00000009993	ENSOANP00000014779	FAT domain-containing protein.	Ku_N domain-containing protein.	0.548
ATM	F7EMV0_ORNAN	ENSOANP00000009993	ENSOANP00000024948	FAT domain-containing protein.	TAN domain-containing protein.	0.901
ATM	F7EMV6_ORNAN	ENSOANP00000009993	ENSOANP00000024947	FAT domain-containing protein.	TAN domain-containing protein.	0.940
ATM	F7FJ30_ORNAN	ENSOANP00000009993	ENSOANP00000005789	FAT domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.500
ATM	FANCD2	ENSOANP00000009993	ENSOANP00000025994	FAT domain-containing protein.	Uncharacterized protein.	0.417
ATM	K7E739_ORNAN	ENSOANP00000009993	ENSOANP00000029346	FAT domain-containing protein.	UME domain-containing protein.	0.500
ATM	K7E7M8_ORNAN	ENSOANP00000009993	ENSOANP00000029535	FAT domain-containing protein.	Uncharacterized protein.	0.500
ATM	K7E8C1_ORNAN	ENSOANP00000009993	ENSOANP00000029778	FAT domain-containing protein.	Uncharacterized protein.	0.742
ATM	K7E960_ORNAN	ENSOANP00000009993	ENSOANP00000030067	FAT domain-containing protein.	Uncharacterized protein.	0.858
ATM	K7EEM2_ORNAN	ENSOANP00000009993	ENSOANP00000031979	FAT domain-containing protein.	Uncharacterized protein.	0.500
ATM	K7EF33_ORNAN	ENSOANP00000009993	ENSOANP00000032140	FAT domain-containing protein.	Uncharacterized protein.	0.500
ATM	K7EF63_ORNAN	ENSOANP00000009993	ENSOANP00000032170	FAT domain-containing protein.	Tower domain-containing protein.	0.453
ATM	K7EHS6_ORNAN	ENSOANP00000009993	ENSOANP00000033083	FAT domain-containing protein.	FAT domain-containing protein.	0.500
ATM	K7EHV5_ORNAN	ENSOANP00000009993	ENSOANP00000033112	FAT domain-containing protein.	Uncharacterized protein.	0.951
ATM	TP53	ENSOANP00000009993	ENSOANP00000018980	FAT domain-containing protein.	P53 domain-containing protein.	0.982
ATM	WRN	ENSOANP00000009993	ENSOANP00000009476	FAT domain-containing protein.	WRN RecQ like helicase.	0.798
ATM	XRCC2	ENSOANP00000009993	ENSOANP00000009843	FAT domain-containing protein.	X-ray repair cross complementing 2.	0.407