(120 nodes) Regulation of macroautophagy network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VPS13D	Vacuolar protein sorting 13 homolog D. (4392 aa)
	K7EI42_ORNAN	Uncharacterized protein. (179 aa)
	K7EGX5_ORNAN	Uncharacterized protein. (238 aa)
	K7EGI6_ORNAN	Uncharacterized protein. (59 aa)
	ULK1	Uncharacterized protein. (95 aa)
	K7EFV3_ORNAN	SMG1_N domain-containing protein. (83 aa)
	K7EFR3_ORNAN	Uncharacterized protein. (637 aa)
	K7EF42_ORNAN	Uncharacterized protein. (218 aa)
	K7EEX3_ORNAN	Uncharacterized protein. (213 aa)
	K7EDL2_ORNAN	Uncharacterized protein. (127 aa)
	K7ECW3_ORNAN	Uncharacterized protein. (138 aa)
	K7ECT4_ORNAN	Uncharacterized protein. (104 aa)
	RNF31	Uncharacterized protein. (119 aa)
	K7EC51_ORNAN	Uncharacterized protein. (145 aa)
	K7EC05_ORNAN	Protein kinase domain-containing protein. (74 aa)
	HTT	Uncharacterized protein. (261 aa)
	K7EBR2_ORNAN	Uncharacterized protein. (117 aa)
	K7EB94_ORNAN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (69 aa)
	K7EAQ0_ORNAN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (76 aa)
	K7EAL4_ORNAN	Protein kinase domain-containing protein. (96 aa)
	K7EAH8_ORNAN	ATG2_CAD domain-containing protein. (130 aa)
	TECPR1-2	Uncharacterized protein. (65 aa)
	K7EA28_ORNAN	Uncharacterized protein. (149 aa)
	K7E9C0_ORNAN	Uncharacterized protein. (247 aa)
	K7E8K7_ORNAN	Uncharacterized protein. (66 aa)
	K7E8F8_ORNAN	Uncharacterized protein. (165 aa)
	K7E864_ORNAN	RAB3GAP2_C domain-containing protein. (78 aa)
	K7E7Z4_ORNAN	Uncharacterized protein. (72 aa)
	K7E7Q6_ORNAN	Uncharacterized protein. (132 aa)
	K7E7N1_ORNAN	DUF4206 domain-containing protein. (130 aa)
	K7E742_ORNAN	Tuberin domain-containing protein. (207 aa)
	K7E737_ORNAN	Protein kinase domain-containing protein. (280 aa)
	K7E6S0_ORNAN	Uncharacterized protein. (139 aa)
	F6YSF5_ORNAN	Uncharacterized protein. (214 aa)
	LRRK2	COR domain-containing protein. (401 aa)
	F6ZQZ9_ORNAN	Uncharacterized protein. (291 aa)
	FEZ2	Fasciculation and elongation protein zeta 2. (283 aa)
	F6ZWH2_ORNAN	SKICH domain-containing protein. (302 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2191 aa)
	F7EB41_ORNAN	Uncharacterized protein. (2219 aa)
	F7G788_ORNAN	PIPK domain-containing protein. (164 aa)
	F7EUH3_ORNAN	Uncharacterized protein. (212 aa)
	F6VR07_ORNAN	Protein kinase domain-containing protein. (259 aa)
	F6WPK1_ORNAN	Uncharacterized protein. (143 aa)
	F6YKP2_ORNAN	Uncharacterized protein. (136 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (315 aa)
	F7CPK5_ORNAN	Uncharacterized protein. (79 aa)
	SCOC	Short coiled-coil protein. (113 aa)
	SESN1	Sestrin 1. (465 aa)
	TIGAR	Uncharacterized protein. (195 aa)
	TBC1D25	TBC1 domain family member 25. (671 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (934 aa)
	SCFD1	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (725 aa)
	F7FN23_ORNAN	Protein kinase domain-containing protein. (1064 aa)
	CLEC16A-2	Uncharacterized protein. (142 aa)
	F7FI40_ORNAN	Uncharacterized protein. (191 aa)
	GPSM1	Uncharacterized protein. (238 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1021 aa)
	RIPK2	CARD domain-containing protein. (334 aa)
	F6T4E5_ORNAN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (179 aa)
	NRBP2	Nuclear receptor binding protein 2. (445 aa)
	SMG1	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (3637 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1284 aa)
	RUBCN	RUN domain-containing protein. (374 aa)
	TP53	P53 domain-containing protein. (87 aa)
	MTM1	Myotubularin 1. (635 aa)
	CLN3	Battenin. (433 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (533 aa)
	HMOX1	Heme oxygenase 1. (290 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (958 aa)
	F6V2U3_ORNAN	Uncharacterized protein. (116 aa)
	LZTS1	Leucine zipper tumor suppressor 1. (616 aa)
	SESN3	Sestrin 3. (479 aa)
	F6YRH5_ORNAN	Protein kinase domain-containing protein. (453 aa)
	SNX7	Sorting nexin 7. (385 aa)
	TSC2	Uncharacterized protein. (625 aa)
	TBK1	TANK binding kinase 1. (700 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (945 aa)
	F6RW96_ORNAN	V-SNARE coiled-coil homology domain-containing protein. (193 aa)
	F6TP73_ORNAN	Uncharacterized protein. (444 aa)
	LRSAM1	Leucine rich repeat and sterile alpha motif containing 1. (754 aa)
	BAG3	BCL2 associated athanogene 3. (520 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (782 aa)
	USP30	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (507 aa)
	SH3GLB1	SH3 domain containing GRB2 like, endophilin B1. (396 aa)
	SUPT5H	SPT5 homolog, DSIF elongation factor subunit. (857 aa)
	F7CUD0_ORNAN	Uncharacterized protein. (136 aa)
	RAB3GAP1	RAB3 GTPase activating protein catalytic subunit 1. (944 aa)
	WIPI1	Uncharacterized protein. (166 aa)
	FYCO1	FYVE and coiled-coil domain containing 1. (1545 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1362 aa)
	F6XAB3_ORNAN	USP8_interact domain-containing protein. (282 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (356 aa)
	WAC	WW domain containing adaptor with coiled-coil. (621 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (351 aa)
	ENSOANP00000008472	annotation not available (109 aa)
	LARP1	La ribonucleoprotein domain family member 1. (977 aa)
	TSC1	Uncharacterized protein. (1167 aa)
	PAFAH1B2	Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (229 aa)
	SIRT1	Uncharacterized protein. (226 aa)
	F6UY84_ORNAN	Uncharacterized protein. (803 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (239 aa)
	TMEM39B	Transmembrane protein 39B. (480 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1361 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (811 aa)
	ATG2A	ATG_C domain-containing protein. (133 aa)
	VPS13C	Vacuolar protein sorting 13 homolog C. (3742 aa)
	ATP6V0A1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (473 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (231 aa)
	F6ST01_ORNAN	UBP-type domain-containing protein. (989 aa)
	TECPR1	Tectonin beta-propeller repeat containing 1. (1168 aa)
	F7GD83_ORNAN	Uncharacterized protein. (242 aa)
	RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2. (1390 aa)
	F6RBJ6_ORNAN	SKICH domain-containing protein. (99 aa)
	SNX30	Sorting nexin family member 30. (387 aa)
	F6YJE8_ORNAN	Uncharacterized protein. (96 aa)
	CLEC16A	C-type lectin domain containing 16A. (859 aa)
	SESN2	Uncharacterized protein. (427 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (481 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (300 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG5	ENSOANP00000022880	ENSOANP00000006175	Autophagy and beclin 1 regulator 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.575
AMBRA1	F7FN23_ORNAN	ENSOANP00000022880	ENSOANP00000021856	Autophagy and beclin 1 regulator 1.	Protein kinase domain-containing protein.	0.676
AMBRA1	K7EAQ0_ORNAN	ENSOANP00000022880	ENSOANP00000030607	Autophagy and beclin 1 regulator 1.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.692
AMBRA1	K7EB94_ORNAN	ENSOANP00000022880	ENSOANP00000030801	Autophagy and beclin 1 regulator 1.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.756
AMBRA1	K7EI42_ORNAN	ENSOANP00000022880	ENSOANP00000033199	Autophagy and beclin 1 regulator 1.	Uncharacterized protein.	0.834
AMBRA1	PIK3C3	ENSOANP00000022880	ENSOANP00000005335	Autophagy and beclin 1 regulator 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.756
AMBRA1	PIK3R4	ENSOANP00000022880	ENSOANP00000010793	Autophagy and beclin 1 regulator 1.	Phosphoinositide-3-kinase regulatory subunit 4.	0.882
AMBRA1	PRKAA2	ENSOANP00000022880	ENSOANP00000018042	Autophagy and beclin 1 regulator 1.	Non-specific serine/threonine protein kinase.	0.443
AMBRA1	SH3GLB1	ENSOANP00000022880	ENSOANP00000013434	Autophagy and beclin 1 regulator 1.	SH3 domain containing GRB2 like, endophilin B1.	0.632
AMBRA1	ULK1	ENSOANP00000022880	ENSOANP00000032558	Autophagy and beclin 1 regulator 1.	Uncharacterized protein.	0.676
ATG2A	F7CUD0_ORNAN	ENSOANP00000005321	ENSOANP00000012827	ATG_C domain-containing protein.	Uncharacterized protein.	0.577
ATG2A	F7FN23_ORNAN	ENSOANP00000005321	ENSOANP00000021856	ATG_C domain-containing protein.	Protein kinase domain-containing protein.	0.599
ATG2A	K7EAH8_ORNAN	ENSOANP00000005321	ENSOANP00000030535	ATG_C domain-containing protein.	ATG2_CAD domain-containing protein.	0.900
ATG2A	ULK1	ENSOANP00000005321	ENSOANP00000032558	ATG_C domain-containing protein.	Uncharacterized protein.	0.958
ATG2A	WIPI1	ENSOANP00000005321	ENSOANP00000012544	ATG_C domain-containing protein.	Uncharacterized protein.	0.955
ATG5	AMBRA1	ENSOANP00000006175	ENSOANP00000022880	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy and beclin 1 regulator 1.	0.575
ATG5	F6VR07_ORNAN	ENSOANP00000006175	ENSOANP00000025769	Autophagy protein 5; Involved in autophagic vesicle formation.	Protein kinase domain-containing protein.	0.547
ATG5	F6YKP2_ORNAN	ENSOANP00000006175	ENSOANP00000025117	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.593
ATG5	F6YRH5_ORNAN	ENSOANP00000006175	ENSOANP00000016490	Autophagy protein 5; Involved in autophagic vesicle formation.	Protein kinase domain-containing protein.	0.547
ATG5	F7CUD0_ORNAN	ENSOANP00000006175	ENSOANP00000012827	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.852