(79 nodes) Negative regulation of angiogenesis network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EPN2	Epsin 2. (583 aa)
	K7EFX6_ORNAN	Uncharacterized protein. (57 aa)
	K7EFP4_ORNAN	Uncharacterized protein. (71 aa)
	K7EEN4_ORNAN	Uncharacterized protein. (293 aa)
	SERPINE1	SERPIN domain-containing protein; Belongs to the serpin family. (190 aa)
	K7E9H2_ORNAN	Uncharacterized protein. (181 aa)
	K7E8Z7_ORNAN	Uncharacterized protein. (135 aa)
	ALOX5	Lipoxygenase domain-containing protein. (110 aa)
	PDE3B	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (278 aa)
	K7E7N2_ORNAN	Uncharacterized protein. (171 aa)
	K7E6V1_ORNAN	Uncharacterized protein. (156 aa)
	F6T9D3_ORNAN	Uncharacterized protein. (562 aa)
	TIE1	EGF-like domain-containing protein. (137 aa)
	F6ZKP3_ORNAN	AGC-kinase C-terminal domain-containing protein. (169 aa)
	NF1	Ras-GAP domain-containing protein. (1467 aa)
	F6TQF8_ORNAN	FERM domain-containing protein. (282 aa)
	F6PHI6_ORNAN	Rab-GAP TBC domain-containing protein. (227 aa)
	F6WR76_ORNAN	Uncharacterized protein. (82 aa)
	EPHA2	EPH receptor A2. (973 aa)
	F7CK33_ORNAN	E2F_TDP domain-containing protein. (460 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
	ADGRB1	Adhesion G protein-coupled receptor B1. (1425 aa)
	SULF1	Sulfatase 1. (889 aa)
	TEK	TEK receptor tyrosine kinase. (1000 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (743 aa)
	F7BNL7_ORNAN	Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (437 aa)
	GTF2I	General transcription factor IIi. (1038 aa)
	ADGRB2	Adhesion G protein-coupled receptor B2; Belongs to the G-protein coupled receptor 2 family. (1456 aa)
	HGS	Uncharacterized protein. (158 aa)
	DAB2IP	DAB2 interacting protein. (991 aa)
	MECP2	Methyl-CpG binding protein 2. (499 aa)
	SERPINF1	Serpin family F member 1; Belongs to the serpin family. (421 aa)
	MINAR1	Membrane integral NOTCH2 associated receptor 1. (917 aa)
	RGCC	Regulator of cell cycle. (172 aa)
	VASH1	Vasohibin 1. (356 aa)
	CNMD	BRICHOS domain-containing protein. (193 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (430 aa)
	F6TRJ5_ORNAN	Sema domain-containing protein; Belongs to the semaphorin family. (688 aa)
	KRIT1	ANK_REP_REGION domain-containing protein. (444 aa)
	SARS1	Seryl-tRNA synthetase. (447 aa)
	HOXA5	Homeobox A5. (269 aa)
	PML	Uncharacterized protein. (331 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	F6QE10_ORNAN	Transforming growth factor beta; Belongs to the TGF-beta family. (416 aa)
	ISM1	Isthmin 1. (428 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (960 aa)
	F6PMZ1_ORNAN	Uncharacterized protein. (1052 aa)
	APOH	Apolipoprotein H. (347 aa)
	THBS4	Uncharacterized protein. (97 aa)
	ABCC8	ATP binding cassette subfamily C member 8. (1586 aa)
	THBS2	Uncharacterized protein. (955 aa)
	TBC1D31	WD_REPEATS_REGION domain-containing protein. (352 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (356 aa)
	F6Q8G6_ORNAN	PDEase domain-containing protein. (150 aa)
	F6PVL6_ORNAN	Uncharacterized protein. (918 aa)
	ANGPT2	Angiopoietin 2. (495 aa)
	F6X7F6_ORNAN	Uncharacterized protein. (444 aa)
	F6R246_ORNAN	SERPIN domain-containing protein; Belongs to the serpin family. (169 aa)
	SPARC	Secreted protein acidic and cysteine rich. (302 aa)
	HHEX	Homeobox domain-containing protein. (63 aa)
	TNMD	Tenomodulin. (318 aa)
	F6U389_ORNAN	Fork-head domain-containing protein. (426 aa)
	TGFB2	TGFb_propeptide domain-containing protein. (117 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (216 aa)
	F6T9H6_ORNAN	Uncharacterized protein. (151 aa)
	THBS1	Thrombospondin 1. (902 aa)
	SYNJ2BP	PDZ domain-containing protein. (125 aa)
	ROCK2	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1285 aa)
	F7BB30_ORNAN	Angiomotin_C domain-containing protein. (650 aa)
	F6SWC6_ORNAN	Uncharacterized protein. (274 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1216 aa)
	F7DB67_ORNAN	G_PROTEIN_RECEP_F2_3 domain-containing protein. (572 aa)
	ADGRB3	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (672 aa)
	STAB1	Stabilin 1. (2537 aa)
	FASLG	Fas ligand; Belongs to the tumor necrosis factor family. (267 aa)
	F7CF78_ORNAN	YjeF N-terminal domain-containing protein. (220 aa)
	F6RGU4_ORNAN	Uncharacterized protein. (512 aa)
	EMILIN1	C1q domain-containing protein. (201 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRB3	F7DB67_ORNAN	ENSOANP00000002594	ENSOANP00000002600	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	G_PROTEIN_RECEP_F2_3 domain-containing protein.	0.900
ADGRB3	K7E6V1_ORNAN	ENSOANP00000002594	ENSOANP00000029258	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.900
ANGPT2	EPHA2	ENSOANP00000008575	ENSOANP00000023610	Angiopoietin 2.	EPH receptor A2.	0.665
ANGPT2	F6PMZ1_ORNAN	ENSOANP00000008575	ENSOANP00000013044	Angiopoietin 2.	Uncharacterized protein.	0.852
ANGPT2	TEK	ENSOANP00000008575	ENSOANP00000020901	Angiopoietin 2.	TEK receptor tyrosine kinase.	0.982
ANGPT2	TIE1	ENSOANP00000008575	ENSOANP00000028781	Angiopoietin 2.	EGF-like domain-containing protein.	0.852
APOH	F6RGU4_ORNAN	ENSOANP00000012816	ENSOANP00000001023	Apolipoprotein H.	Uncharacterized protein.	0.720
CLDN5	TEK	ENSOANP00000005668	ENSOANP00000020901	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	TEK receptor tyrosine kinase.	0.411
CTNNB1	EPHA2	ENSOANP00000010865	ENSOANP00000023610	Catenin beta 1.	EPH receptor A2.	0.404
CTNNB1	KRIT1	ENSOANP00000010865	ENSOANP00000015094	Catenin beta 1.	ANK_REP_REGION domain-containing protein.	0.920
CTNNB1	ROCK2	ENSOANP00000010865	ENSOANP00000004245	Catenin beta 1.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.938
DAB2IP	F6PVL6_ORNAN	ENSOANP00000018946	ENSOANP00000009021	DAB2 interacting protein.	Uncharacterized protein.	0.410
DAB2IP	K7EFP4_ORNAN	ENSOANP00000018946	ENSOANP00000032351	DAB2 interacting protein.	Uncharacterized protein.	0.410
DAB2IP	NF1	ENSOANP00000018946	ENSOANP00000027864	DAB2 interacting protein.	Ras-GAP domain-containing protein.	0.410
DCN	EMILIN1	ENSOANP00000010570	ENSOANP00000000812	Decorin; May affect the rate of fibrils formation.	C1q domain-containing protein.	0.444
DCN	F6QE10_ORNAN	ENSOANP00000010570	ENSOANP00000013619	Decorin; May affect the rate of fibrils formation.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.466
DCN	SPARC	ENSOANP00000010570	ENSOANP00000008115	Decorin; May affect the rate of fibrils formation.	Secreted protein acidic and cysteine rich.	0.843
DCN	TGFB2	ENSOANP00000010570	ENSOANP00000005996	Decorin; May affect the rate of fibrils formation.	TGFb_propeptide domain-containing protein.	0.937
DCN	THBS1	ENSOANP00000010570	ENSOANP00000004444	Decorin; May affect the rate of fibrils formation.	Thrombospondin 1.	0.704
DCN	THBS2	ENSOANP00000010570	ENSOANP00000012109	Decorin; May affect the rate of fibrils formation.	Uncharacterized protein.	0.417