(13 nodes) Single-stranded DNA helicase activity network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DHX9	Uncharacterized protein. (1273 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (634 aa)
	HELQ	Uncharacterized protein. (727 aa)
	POLQ	Uncharacterized protein. (1886 aa)
	HELB	UvrD_C_2 domain-containing protein. (994 aa)
	RFC2	Replication factor C subunit 2. (316 aa)
	K7EAX3_ORNAN	Uncharacterized protein. (117 aa)
	K7E8M8_ORNAN	RECA_2 domain-containing protein. (216 aa)
	K7E6F9_ORNAN	Uncharacterized protein. (156 aa)
	WRNIP1	Uncharacterized protein. (349 aa)
	DNA2	Uncharacterized protein. (567 aa)
	F7FDD9_ORNAN	Dna2 domain-containing protein. (341 aa)
	RAD51	Uncharacterized protein. (119 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNA2	F7FDD9_ORNAN	ENSOANP00000023693	ENSOANP00000016052	Uncharacterized protein.	Dna2 domain-containing protein.	0.934
DNA2	HELQ	ENSOANP00000023693	ENSOANP00000003355	Uncharacterized protein.	Uncharacterized protein.	0.454
DNA2	K7E8M8_ORNAN	ENSOANP00000023693	ENSOANP00000029885	Uncharacterized protein.	RECA_2 domain-containing protein.	0.849
DNA2	PIF1	ENSOANP00000023693	ENSOANP00000001814	Uncharacterized protein.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.864
DNA2	POLQ	ENSOANP00000023693	ENSOANP00000007028	Uncharacterized protein.	Uncharacterized protein.	0.459
DNA2	RAD51	ENSOANP00000023693	ENSOANP00000014708	Uncharacterized protein.	Uncharacterized protein.	0.820
DNA2	RFC2	ENSOANP00000023693	ENSOANP00000011669	Uncharacterized protein.	Replication factor C subunit 2.	0.655
DNA2	WRNIP1	ENSOANP00000023693	ENSOANP00000024806	Uncharacterized protein.	Uncharacterized protein.	0.505
F7FDD9_ORNAN	DNA2	ENSOANP00000016052	ENSOANP00000023693	Dna2 domain-containing protein.	Uncharacterized protein.	0.934
F7FDD9_ORNAN	K7E8M8_ORNAN	ENSOANP00000016052	ENSOANP00000029885	Dna2 domain-containing protein.	RECA_2 domain-containing protein.	0.739
F7FDD9_ORNAN	PIF1	ENSOANP00000016052	ENSOANP00000001814	Dna2 domain-containing protein.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.799
F7FDD9_ORNAN	RAD51	ENSOANP00000016052	ENSOANP00000014708	Dna2 domain-containing protein.	Uncharacterized protein.	0.661
F7FDD9_ORNAN	RFC2	ENSOANP00000016052	ENSOANP00000011669	Dna2 domain-containing protein.	Replication factor C subunit 2.	0.603
F7FDD9_ORNAN	WRNIP1	ENSOANP00000016052	ENSOANP00000024806	Dna2 domain-containing protein.	Uncharacterized protein.	0.505
HELQ	DNA2	ENSOANP00000003355	ENSOANP00000023693	Uncharacterized protein.	Uncharacterized protein.	0.454
HELQ	K7E8M8_ORNAN	ENSOANP00000003355	ENSOANP00000029885	Uncharacterized protein.	RECA_2 domain-containing protein.	0.531
HELQ	PIF1	ENSOANP00000003355	ENSOANP00000001814	Uncharacterized protein.	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]	0.416
HELQ	POLQ	ENSOANP00000003355	ENSOANP00000007028	Uncharacterized protein.	Uncharacterized protein.	0.603
HELQ	RAD51	ENSOANP00000003355	ENSOANP00000014708	Uncharacterized protein.	Uncharacterized protein.	0.531
K7E8M8_ORNAN	DNA2	ENSOANP00000029885	ENSOANP00000023693	RECA_2 domain-containing protein.	Uncharacterized protein.	0.849