(78 nodes) Regulation of mitotic metaphase/anaphase transition network (Ornithorhynchus anatinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	F7A842_ORNAN	Protein kinase domain-containing protein. (813 aa)
	K7EI97_ORNAN	HORMA domain-containing protein. (83 aa)
	K7EHV5_ORNAN	Uncharacterized protein. (251 aa)
	UBE2C	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (102 aa)
	K7EH90_ORNAN	ANAPC8 domain-containing protein. (143 aa)
	K7EGQ6_ORNAN	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (121 aa)
	K7EG55_ORNAN	ATPase_AAA_core domain-containing protein. (80 aa)
	GEN1	Uncharacterized protein. (132 aa)
	K7EFD6_ORNAN	Uncharacterized protein. (177 aa)
	K7EES5_ORNAN	Uncharacterized protein. (116 aa)
	K7EEI2_ORNAN	USP domain-containing protein; Belongs to the peptidase C19 family. (112 aa)
	K7EEB9_ORNAN	Uncharacterized protein. (102 aa)
	K7ED41_ORNAN	Cdc6_C domain-containing protein. (115 aa)
	K7ECV0_ORNAN	Uncharacterized protein. (83 aa)
	K7EBU9_ORNAN	Uncharacterized protein. (102 aa)
	K7EBS5_ORNAN	Uncharacterized protein. (129 aa)
	K7EAL5_ORNAN	FAT domain-containing protein. (153 aa)
	CENPE	Uncharacterized protein. (595 aa)
	K7EAK0_ORNAN	Uncharacterized protein. (142 aa)
	K7EA92_ORNAN	FAT domain-containing protein. (108 aa)
	CDC16	TPR_REGION domain-containing protein. (313 aa)
	K7E9X2_ORNAN	Uncharacterized protein. (110 aa)
	K7E9Q0_ORNAN	Uncharacterized protein. (90 aa)
	K7E9D1_ORNAN	Uncharacterized protein. (560 aa)
	K7E960_ORNAN	Uncharacterized protein. (152 aa)
	K7E8U2_ORNAN	RIO domain-containing protein. (113 aa)
	K7E820_ORNAN	Uncharacterized protein. (138 aa)
	K7E7U9_ORNAN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (77 aa)
	ENSOANP00000029586	annotation not available (99 aa)
	K7E7P2_ORNAN	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (130 aa)
	K7E7A8_ORNAN	TPR_MLP1_2 domain-containing protein. (170 aa)
	ANAPC11	Uncharacterized protein. (96 aa)
	F7F715_ORNAN	Cnn_1N domain-containing protein. (128 aa)
	F7FIT2_ORNAN	Uncharacterized protein. (235 aa)
	NSMCE2	SP-RING-type domain-containing protein. (91 aa)
	F7EMV0_ORNAN	TAN domain-containing protein. (121 aa)
	F7EMV6_ORNAN	TAN domain-containing protein. (316 aa)
	F7EMW0_ORNAN	Uncharacterized protein. (86 aa)
	PCID2	PCI domain containing 2. (411 aa)
	RB1	Uncharacterized protein. (725 aa)
	CDC6	AAA domain-containing protein. (372 aa)
	ZW10	Zw10 kinetochore protein. (596 aa)
	F7E3J1_ORNAN	CDT1 domain-containing protein. (445 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1122 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (642 aa)
	BUB3	BUB3 mitotic checkpoint protein. (278 aa)
	BCL7C	BAF chromatin remodeling complex subunit BCL7C. (224 aa)
	ZNF207	Zinc finger protein 207. (496 aa)
	NDC80	NDC80 kinetochore complex component. (649 aa)
	F6RG50_ORNAN	BUB1 N-terminal domain-containing protein. (1033 aa)
	DYNC1LI1	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (437 aa)
	CDC26	Cell division cycle 26. (85 aa)
	F6YH45_ORNAN	Uncharacterized protein. (1187 aa)
	F7EW15_ORNAN	XPGI domain-containing protein. (807 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (446 aa)
	PLK1	Polo like kinase 1. (479 aa)
	CDC27	Uncharacterized protein. (400 aa)
	F7E9T2_ORNAN	BTB domain-containing protein. (604 aa)
	ANAPC4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (810 aa)
	USP44	Ubiquitinyl hydrolase 1. (589 aa)
	PSMG2	Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (247 aa)
	ATM	FAT domain-containing protein. (1029 aa)
	BCL7A	BAF chromatin remodeling complex subunit BCL7A. (227 aa)
	F6XPE0_ORNAN	HORMA domain-containing protein. (228 aa)
	KNTC1	Kinetochore associated 1. (1847 aa)
	ANAPC7	Anaphase promoting complex subunit 7. (531 aa)
	ZWILCH	Zwilch kinetochore protein. (594 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (544 aa)
	F6TGR1_ORNAN	TPR_REGION domain-containing protein. (364 aa)
	MAD2L1BP	MAD2L1 binding protein. (238 aa)
	LCMT1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (318 aa)
	F7FAA9_ORNAN	Cullin domain-containing protein; Belongs to the cullin family. (91 aa)
	TTK	TTK protein kinase. (893 aa)
	RIOK2	RIO domain-containing protein. (536 aa)
	TPR	TPR_MLP1_2 domain-containing protein. (2364 aa)
	APC	APC regulator of WNT signaling pathway. (2844 aa)
	ANAPC5	Uncharacterized protein. (438 aa)
	XRCC3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (361 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC11	ANAPC4	ENSOANP00000029341	ENSOANP00000010687	Uncharacterized protein.	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.	0.996
ANAPC11	ANAPC5	ENSOANP00000029341	ENSOANP00000001245	Uncharacterized protein.	Uncharacterized protein.	0.996
ANAPC11	ANAPC7	ENSOANP00000029341	ENSOANP00000007565	Uncharacterized protein.	Anaphase promoting complex subunit 7.	0.994
ANAPC11	BUB1	ENSOANP00000029341	ENSOANP00000019968	Uncharacterized protein.	BUB1 mitotic checkpoint serine/threonine kinase.	0.885
ANAPC11	BUB3	ENSOANP00000029341	ENSOANP00000019269	Uncharacterized protein.	BUB3 mitotic checkpoint protein.	0.983
ANAPC11	CDC16	ENSOANP00000029341	ENSOANP00000030411	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.996
ANAPC11	CDC26	ENSOANP00000029341	ENSOANP00000015412	Uncharacterized protein.	Cell division cycle 26.	0.993
ANAPC11	CDC27	ENSOANP00000029341	ENSOANP00000011546	Uncharacterized protein.	Uncharacterized protein.	0.996
ANAPC11	CDC6	ENSOANP00000029341	ENSOANP00000024344	Uncharacterized protein.	AAA domain-containing protein.	0.530
ANAPC11	ENSOANP00000029586	ENSOANP00000029341	ENSOANP00000029586	Uncharacterized protein.	annotation not available	0.962
ANAPC11	F6RG50_ORNAN	ENSOANP00000029341	ENSOANP00000016996	Uncharacterized protein.	BUB1 N-terminal domain-containing protein.	0.889
ANAPC11	F6TGR1_ORNAN	ENSOANP00000029341	ENSOANP00000005396	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.962
ANAPC11	F6XPE0_ORNAN	ENSOANP00000029341	ENSOANP00000009903	Uncharacterized protein.	HORMA domain-containing protein.	0.635
ANAPC11	F7E3J1_ORNAN	ENSOANP00000029341	ENSOANP00000021918	Uncharacterized protein.	CDT1 domain-containing protein.	0.560
ANAPC11	F7FIT2_ORNAN	ENSOANP00000029341	ENSOANP00000026083	Uncharacterized protein.	Uncharacterized protein.	0.962
ANAPC11	K7EAK0_ORNAN	ENSOANP00000029341	ENSOANP00000030557	Uncharacterized protein.	Uncharacterized protein.	0.962
ANAPC11	K7ECV0_ORNAN	ENSOANP00000029341	ENSOANP00000031357	Uncharacterized protein.	Uncharacterized protein.	0.496
ANAPC11	K7ED41_ORNAN	ENSOANP00000029341	ENSOANP00000031448	Uncharacterized protein.	Cdc6_C domain-containing protein.	0.530
ANAPC11	K7EH90_ORNAN	ENSOANP00000029341	ENSOANP00000032897	Uncharacterized protein.	ANAPC8 domain-containing protein.	0.998
ANAPC11	K7EI97_ORNAN	ENSOANP00000029341	ENSOANP00000033254	Uncharacterized protein.	HORMA domain-containing protein.	0.635