(21 nodes) DNA damage response, signal transduction by p53 class mediator network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TFAP4	BHLH domain-containing protein. (235 aa)
	BRCA2	Tower domain-containing protein. (3459 aa)
	K7EF63_ORNAN	Tower domain-containing protein. (94 aa)
	NDRG1	N-myc downstream regulated 1. (388 aa)
	PML	Uncharacterized protein. (331 aa)
	CHEK2	Checkpoint kinase 2. (553 aa)
	E2F7	Uncharacterized protein. (408 aa)
	F6WWD2_ORNAN	Uncharacterized protein. (304 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (760 aa)
	RPS6KA6	Non-specific serine/threonine protein kinase. (714 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (411 aa)
	ATRX	ATRX chromatin remodeler. (2423 aa)
	F7EZ11_ORNAN	GTSE1_N domain-containing protein. (707 aa)
	FOXM1	Fork-head domain-containing protein. (183 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1293 aa)
	SESN2	Uncharacterized protein. (427 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (468 aa)
	TP53	P53 domain-containing protein. (87 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (464 aa)
	F7CPK5_ORNAN	Uncharacterized protein. (79 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (150 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRX	BRCA2	ENSOANP00000003785	ENSOANP00000024376	ATRX chromatin remodeler.	Tower domain-containing protein.	0.420
ATRX	CHEK2	ENSOANP00000003785	ENSOANP00000014054	ATRX chromatin remodeler.	Checkpoint kinase 2.	0.435
ATRX	K7EF63_ORNAN	ENSOANP00000003785	ENSOANP00000032170	ATRX chromatin remodeler.	Tower domain-containing protein.	0.420
ATRX	TP53	ENSOANP00000003785	ENSOANP00000018980	ATRX chromatin remodeler.	P53 domain-containing protein.	0.759
BRCA2	ATRX	ENSOANP00000024376	ENSOANP00000003785	Tower domain-containing protein.	ATRX chromatin remodeler.	0.420
BRCA2	CHEK2	ENSOANP00000024376	ENSOANP00000014054	Tower domain-containing protein.	Checkpoint kinase 2.	0.763
BRCA2	TP53	ENSOANP00000024376	ENSOANP00000018980	Tower domain-containing protein.	P53 domain-containing protein.	0.824
CASP2	TP53	ENSOANP00000005545	ENSOANP00000018980	Caspase 2; Belongs to the peptidase C14A family.	P53 domain-containing protein.	0.507
CHEK2	ATRX	ENSOANP00000014054	ENSOANP00000003785	Checkpoint kinase 2.	ATRX chromatin remodeler.	0.435
CHEK2	BRCA2	ENSOANP00000014054	ENSOANP00000024376	Checkpoint kinase 2.	Tower domain-containing protein.	0.763
CHEK2	K7EF63_ORNAN	ENSOANP00000014054	ENSOANP00000032170	Checkpoint kinase 2.	Tower domain-containing protein.	0.591
CHEK2	MDM4	ENSOANP00000014054	ENSOANP00000021247	Checkpoint kinase 2.	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.735
CHEK2	PPM1D	ENSOANP00000014054	ENSOANP00000018259	Checkpoint kinase 2.	Protein phosphatase, Mg2+/Mn2+ dependent 1D.	0.685
CHEK2	TP53	ENSOANP00000014054	ENSOANP00000018980	Checkpoint kinase 2.	P53 domain-containing protein.	0.996
E2F7	F6WWD2_ORNAN	ENSOANP00000011861	ENSOANP00000011859	Uncharacterized protein.	Uncharacterized protein.	0.900
E2F7	TP53	ENSOANP00000011861	ENSOANP00000018980	Uncharacterized protein.	P53 domain-containing protein.	0.400
F6WWD2_ORNAN	E2F7	ENSOANP00000011859	ENSOANP00000011861	Uncharacterized protein.	Uncharacterized protein.	0.900
F6WWD2_ORNAN	TP53	ENSOANP00000011859	ENSOANP00000018980	Uncharacterized protein.	P53 domain-containing protein.	0.400
F7CPK5_ORNAN	SESN2	ENSOANP00000024104	ENSOANP00000000989	Uncharacterized protein.	Uncharacterized protein.	0.409
F7EZ11_ORNAN	TP53	ENSOANP00000002996	ENSOANP00000018980	GTSE1_N domain-containing protein.	P53 domain-containing protein.	0.665