(97 nodes) Adult behavior network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (518 aa)
	EPS8	Uncharacterized protein. (134 aa)
	K7EGX4_ORNAN	BBS2_C domain-containing protein. (129 aa)
	SHANK1	ANK_REP_REGION domain-containing protein. (86 aa)
	K7EFY7_ORNAN	Uncharacterized protein. (206 aa)
	K7EEV1_ORNAN	SAC domain-containing protein. (166 aa)
	K7EDG8_ORNAN	Uncharacterized protein. (57 aa)
	CRHBP	Uncharacterized protein. (127 aa)
	K7E8Q7_ORNAN	Uncharacterized protein. (78 aa)
	PCDH15	Uncharacterized protein. (91 aa)
	K7E8J4_ORNAN	Uncharacterized protein. (65 aa)
	K7E7Q6_ORNAN	Uncharacterized protein. (132 aa)
	K7E7J7_ORNAN	CA domain-containing protein. (78 aa)
	F6RIW8_ORNAN	Uncharacterized protein. (212 aa)
	F7AA14_ORNAN	Uncharacterized protein. (106 aa)
	F6TQI5_ORNAN	zf-RING_14 domain-containing protein. (71 aa)
	F6ZX51_ORNAN	Uncharacterized protein. (123 aa)
	CTNS	Cystinosin, lysosomal cystine transporter. (370 aa)
	GLRB	Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
	MAFG	MAF bZIP transcription factor G. (166 aa)
	FOXA2	Fork-head domain-containing protein. (280 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	ADAM22	Uncharacterized protein. (354 aa)
	HOXB8	Homeobox B8. (155 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (304 aa)
	F6QAC6_ORNAN	Uncharacterized protein. (82 aa)
	HEXA	Glyco_hydro_20 domain-containing protein. (265 aa)
	BBS4	Bardet-Biedl syndrome 4. (561 aa)
	CNTN2	Contactin 2. (1044 aa)
	dmrt1-2	Doublesex and mab-3 related transcription factor 1. (46 aa)
	CHRNB4	Uncharacterized protein. (486 aa)
	CHRNA3	Cholinergic receptor nicotinic alpha 3 subunit. (496 aa)
	CHRNA5	Cholinergic receptor nicotinic alpha 5 subunit. (470 aa)
	BTBD9	BTB domain containing 9. (512 aa)
	AGTPBP1	ATP/GTP binding protein 1. (1146 aa)
	F6U064_ORNAN	A4_EXTRA domain-containing protein. (425 aa)
	F7A6M6_ORNAN	Uncharacterized protein. (338 aa)
	F6U411_ORNAN	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (462 aa)
	F7FLS7_ORNAN	Uncharacterized protein. (466 aa)
	F7FM63_ORNAN	LRRCT domain-containing protein. (425 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1284 aa)
	PRKN	Ubiquitin-like domain-containing protein. (54 aa)
	SLITRK5	SLIT and NTRK like family member 5. (977 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2492 aa)
	MECP2	Methyl-CpG binding protein 2. (499 aa)
	DRD2	Dopamine receptor D2. (459 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (707 aa)
	KLHL5	Kelch like family member 5. (624 aa)
	F6TP73_ORNAN	Uncharacterized protein. (444 aa)
	SLC7A11	Solute carrier family 7 member 11. (411 aa)
	DMBX1	Diencephalon/mesencephalon homeobox 1. (367 aa)
	F7GBG5_ORNAN	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (210 aa)
	RNF180	Uncharacterized protein. (366 aa)
	SEZ6	Uncharacterized protein. (316 aa)
	HOXD10	Homeobox D10. (335 aa)
	OXR1	Oxidation resistance 1. (683 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (474 aa)
	F7CV75_ORNAN	Uncharacterized protein. (466 aa)
	HOMER1	Uncharacterized protein. (268 aa)
	KLHL1	Uncharacterized protein. (201 aa)
	SHANK2	Uncharacterized protein. (1257 aa)
	SEZ6L2	Seizure related 6 homolog like 2. (909 aa)
	CHRNB1	Cholinergic receptor nicotinic beta 1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (345 aa)
	BBS1	BBS1 domain-containing protein. (371 aa)
	F6WJ16_ORNAN	Uncharacterized protein. (612 aa)
	CACNB4	SH3 domain-containing protein. (473 aa)
	HOMER2	Homer scaffold protein 2. (364 aa)
	F6W0M3_ORNAN	BTB domain-containing protein. (545 aa)
	GRM2	Glutamate metabotropic receptor 2. (870 aa)
	F7B9A1_ORNAN	Uncharacterized protein. (425 aa)
	F6UI95_ORNAN	Uncharacterized protein. (848 aa)
	F6R235_ORNAN	Peptidase M12B domain-containing protein. (249 aa)
	NTAN1	Uncharacterized protein. (304 aa)
	TSC1	Uncharacterized protein. (1167 aa)
	F6R437_ORNAN	Uncharacterized protein. (653 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2084 aa)
	F7DIY8_ORNAN	RING-type domain-containing protein. (242 aa)
	F7FTY3_ORNAN	PUM-HD domain-containing protein. (949 aa)
	SDK1	Sidekick cell adhesion molecule 1. (2047 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	F7G946_ORNAN	Uncharacterized protein. (96 aa)
	ARCN1	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (511 aa)
	CHRNA4	Cholinergic receptor nicotinic alpha 4 subunit. (624 aa)
	AGRP	Agouti domain-containing protein. (140 aa)
	F6UC14_ORNAN	Uncharacterized protein. (374 aa)
	F6UD88_ORNAN	Uncharacterized protein. (203 aa)
	EN1	Homeobox protein engrailed-like. (110 aa)
	DBH	Dopamine beta-hydroxylase. (621 aa)
	F7FT20_ORNAN	PH domain-containing protein. (648 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (723 aa)
	ABAT	Uncharacterized protein. (241 aa)
	TMOD1	Tropomodulin 1. (359 aa)
	F7AQ17_ORNAN	Uncharacterized protein. (447 aa)
	F7EZQ3_ORNAN	Uncharacterized protein. (1109 aa)
	INPP5F	Uncharacterized protein. (750 aa)
	F6Z6T8_ORNAN	CAP-Gly domain-containing protein. (540 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABAT	F7AA14_ORNAN	ENSOANP00000003125	ENSOANP00000028611	Uncharacterized protein.	Uncharacterized protein.	0.950
ADAM22	F6R235_ORNAN	ENSOANP00000023406	ENSOANP00000008217	Uncharacterized protein.	Peptidase M12B domain-containing protein.	0.900
ADAM22	F7FM63_ORNAN	ENSOANP00000023406	ENSOANP00000019779	Uncharacterized protein.	LRRCT domain-containing protein.	0.699
AGRP	F6QAC6_ORNAN	ENSOANP00000005612	ENSOANP00000022113	Agouti domain-containing protein.	Uncharacterized protein.	0.574
AGRP	LEP	ENSOANP00000005612	ENSOANP00000001265	Agouti domain-containing protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.751
BBS1	BBS2	ENSOANP00000011240	ENSOANP00000003323	BBS1 domain-containing protein.	Bardet-Biedl syndrome 2 protein homolog.	0.974
BBS1	BBS4	ENSOANP00000011240	ENSOANP00000021791	BBS1 domain-containing protein.	Bardet-Biedl syndrome 4.	0.993
BBS1	F6UD88_ORNAN	ENSOANP00000011240	ENSOANP00000005352	BBS1 domain-containing protein.	Uncharacterized protein.	0.622
BBS1	F6W0M3_ORNAN	ENSOANP00000011240	ENSOANP00000009574	BBS1 domain-containing protein.	BTB domain-containing protein.	0.622
BBS1	K7EGX4_ORNAN	ENSOANP00000011240	ENSOANP00000032781	BBS1 domain-containing protein.	BBS2_C domain-containing protein.	0.947
BBS1	KLHL1	ENSOANP00000011240	ENSOANP00000012265	BBS1 domain-containing protein.	Uncharacterized protein.	0.622
BBS1	KLHL5	ENSOANP00000011240	ENSOANP00000016377	BBS1 domain-containing protein.	Kelch like family member 5.	0.622
BBS2	BBS1	ENSOANP00000003323	ENSOANP00000011240	Bardet-Biedl syndrome 2 protein homolog.	BBS1 domain-containing protein.	0.974
BBS2	BBS4	ENSOANP00000003323	ENSOANP00000021791	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.951
BBS4	BBS1	ENSOANP00000021791	ENSOANP00000011240	Bardet-Biedl syndrome 4.	BBS1 domain-containing protein.	0.993
BBS4	BBS2	ENSOANP00000021791	ENSOANP00000003323	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.951
BBS4	CACNB4	ENSOANP00000021791	ENSOANP00000009737	Bardet-Biedl syndrome 4.	SH3 domain-containing protein.	0.719
BBS4	F6UD88_ORNAN	ENSOANP00000021791	ENSOANP00000005352	Bardet-Biedl syndrome 4.	Uncharacterized protein.	0.585
BBS4	F6W0M3_ORNAN	ENSOANP00000021791	ENSOANP00000009574	Bardet-Biedl syndrome 4.	BTB domain-containing protein.	0.585
BBS4	K7EGX4_ORNAN	ENSOANP00000021791	ENSOANP00000032781	Bardet-Biedl syndrome 4.	BBS2_C domain-containing protein.	0.927