(33 nodes) Positive regulation of interleukin-2 production network (Ornithorhynchus anatinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDE4B	PDEase domain-containing protein. (212 aa)
	F6QCH5_ORNAN	Uncharacterized protein. (68 aa)
	MALT1	CASPASE_P20 domain-containing protein. (470 aa)
	F6TZM5_ORNAN	Uncharacterized protein. (398 aa)
	CARD11	Uncharacterized protein. (1156 aa)
	CLEC7A	C-type lectin domain-containing protein. (199 aa)
	F6PFX1_ORNAN	Signal transducer and activator of transcription. (755 aa)
	MAP3K7	Protein kinase domain-containing protein. (506 aa)
	F6RUJ4_ORNAN	KH type-2 domain-containing protein. (211 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (290 aa)
	F7DH67_ORNAN	CARD domain-containing protein. (121 aa)
	F7GEP6_ORNAN	Phosphoinositide phospholipase C. (1097 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
	ANXA1	Annexin. (357 aa)
	GLMN	Glomulin, FKBP associated protein. (599 aa)
	RIPK2	CARD domain-containing protein. (334 aa)
	PTPRC	Uncharacterized protein. (548 aa)
	SASH3	SAM and SH3 domain containing 3. (384 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (708 aa)
	ENSOANP00000024320	annotation not available (149 aa)
	F7BN07_ORNAN	Tyrosine-protein phosphatase domain-containing protein. (196 aa)
	F6WK32_ORNAN	PHB domain-containing protein. (244 aa)
	F7ETK2_ORNAN	Protein kinase domain-containing protein. (176 aa)
	F6QIR6_ORNAN	Uncharacterized protein. (274 aa)
	K7E737_ORNAN	Protein kinase domain-containing protein. (280 aa)
	K7E7Z0_ORNAN	Band_7_C domain-containing protein. (150 aa)
	ENSOANP00000029717	annotation not available (96 aa)
	RPS3	KH type-2 domain-containing protein. (143 aa)
	PLCG2	SH2 domain-containing protein. (238 aa)
	K7EC05_ORNAN	Protein kinase domain-containing protein. (74 aa)
	K7EDB3_ORNAN	PH domain-containing protein. (104 aa)
	K7EF27_ORNAN	Uncharacterized protein. (228 aa)
	K7EHE9_ORNAN	Ig_6 domain-containing protein. (67 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	IL1B	ENSOANP00000020763	ENSOANP00000016712	Annexin.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.440
CARD11	ENSOANP00000024320	ENSOANP00000006865	ENSOANP00000024320	Uncharacterized protein.	annotation not available	0.695
CARD11	ENSOANP00000029717	ENSOANP00000006865	ENSOANP00000029717	Uncharacterized protein.	annotation not available	0.695
CARD11	F7ETK2_ORNAN	ENSOANP00000006865	ENSOANP00000026511	Uncharacterized protein.	Protein kinase domain-containing protein.	0.563
CARD11	K7EHE9_ORNAN	ENSOANP00000006865	ENSOANP00000032956	Uncharacterized protein.	Ig_6 domain-containing protein.	0.753
CARD11	MALT1	ENSOANP00000006865	ENSOANP00000005450	Uncharacterized protein.	CASPASE_P20 domain-containing protein.	0.948
CARD11	MAP3K7	ENSOANP00000006865	ENSOANP00000014216	Uncharacterized protein.	Protein kinase domain-containing protein.	0.563
CARD11	PRKCQ	ENSOANP00000006865	ENSOANP00000024315	Uncharacterized protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.968
CARD11	TRAF6	ENSOANP00000006865	ENSOANP00000018657	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.683
ENSOANP00000024320	CARD11	ENSOANP00000024320	ENSOANP00000006865	annotation not available	Uncharacterized protein.	0.695
ENSOANP00000024320	F7DH67_ORNAN	ENSOANP00000024320	ENSOANP00000017420	annotation not available	CARD domain-containing protein.	0.695
ENSOANP00000024320	F7ETK2_ORNAN	ENSOANP00000024320	ENSOANP00000026511	annotation not available	Protein kinase domain-containing protein.	0.482
ENSOANP00000024320	K7E737_ORNAN	ENSOANP00000024320	ENSOANP00000029344	annotation not available	Protein kinase domain-containing protein.	0.449
ENSOANP00000024320	K7EHE9_ORNAN	ENSOANP00000024320	ENSOANP00000032956	annotation not available	Ig_6 domain-containing protein.	0.420
ENSOANP00000024320	MALT1	ENSOANP00000024320	ENSOANP00000005450	annotation not available	CASPASE_P20 domain-containing protein.	0.420
ENSOANP00000024320	TRAF6	ENSOANP00000024320	ENSOANP00000018657	annotation not available	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.502
ENSOANP00000029717	CARD11	ENSOANP00000029717	ENSOANP00000006865	annotation not available	Uncharacterized protein.	0.695
ENSOANP00000029717	F7DH67_ORNAN	ENSOANP00000029717	ENSOANP00000017420	annotation not available	CARD domain-containing protein.	0.695
ENSOANP00000029717	K7EHE9_ORNAN	ENSOANP00000029717	ENSOANP00000032956	annotation not available	Ig_6 domain-containing protein.	0.420
ENSOANP00000029717	MALT1	ENSOANP00000029717	ENSOANP00000005450	annotation not available	CASPASE_P20 domain-containing protein.	0.420