STRINGSTRING
ITGB1 ITGB1 PTPN11 PTPN11 P2RX7 P2RX7 SLC17A8 SLC17A8 IGF1 IGF1 F6UI95_ORNAN F6UI95_ORNAN EDNRA EDNRA SORBS1 SORBS1 F7FZN3_ORNAN F7FZN3_ORNAN CHP1 CHP1 ADIPOQ ADIPOQ F7BP39_ORNAN F7BP39_ORNAN SLC7A5 SLC7A5 TRPC1 TRPC1 F7D6S0_ORNAN F7D6S0_ORNAN AMIGO2 AMIGO2 F6TH95_ORNAN F6TH95_ORNAN GPER1 GPER1 F7B581_ORNAN F7B581_ORNAN F6TF38_ORNAN F6TF38_ORNAN RNF207 RNF207 ACE2 ACE2 CLTRN CLTRN KCNE1 KCNE1 F7AI10_ORNAN F7AI10_ORNAN F6UHR1_ORNAN F6UHR1_ORNAN PDPK1 PDPK1 VMP1 VMP1 F7ALN7_ORNAN F7ALN7_ORNAN NR4A3 NR4A3 THY1 THY1 WNK2 WNK2 CA2 CA2 F7FEI4_ORNAN F7FEI4_ORNAN SRI SRI ACSL5 ACSL5 APPL1 APPL1 F7EVG8_ORNAN F7EVG8_ORNAN PSEN1 PSEN1 RNASEL RNASEL COA8 COA8 CREBL2 CREBL2 WNK3 WNK3 ATP1B3 ATP1B3 G6PD G6PD RAMP3 RAMP3 MEF2A MEF2A F6W8B0_ORNAN F6W8B0_ORNAN LRRC38 LRRC38 CACNB4 CACNB4 APLNR APLNR OSBPL8 OSBPL8 F6WGS8_ORNAN F6WGS8_ORNAN STIM2 STIM2 F7EHS9_ORNAN F7EHS9_ORNAN EDN1 EDN1 CHP2 CHP2 FGF19 FGF19 ABCC8 ABCC8 F6UEH0_ORNAN F6UEH0_ORNAN R3HDM1 R3HDM1 CACNG4 CACNG4 NFE2L2 NFE2L2 CFTR CFTR LRRC55 LRRC55 ACTN2 ACTN2 STIM1 STIM1 PDZK1 PDZK1 F6ZIW3_ORNAN F6ZIW3_ORNAN F6YRH5_ORNAN F6YRH5_ORNAN TRPC6 TRPC6 F6V2U3_ORNAN F6V2U3_ORNAN FLNA FLNA F7D453_ORNAN F7D453_ORNAN F7GEP6_ORNAN F7GEP6_ORNAN F6RE34_ORNAN F6RE34_ORNAN F7AVI5_ORNAN F7AVI5_ORNAN ATPSCKMT ATPSCKMT GPC3 GPC3 F7FGE5_ORNAN F7FGE5_ORNAN CAPN10 CAPN10 CACNB3 CACNB3 CACNG2 CACNG2 F6ZBY6_ORNAN F6ZBY6_ORNAN F2RL3 F2RL3 ANO6 ANO6 BRAF BRAF F7FHN9_ORNAN F7FHN9_ORNAN F7EC32_ORNAN F7EC32_ORNAN AZIN1 AZIN1 CEMIP CEMIP F7FGH1_ORNAN F7FGH1_ORNAN F7DV77_ORNAN F7DV77_ORNAN F7DV18_ORNAN F7DV18_ORNAN AKAP6 AKAP6 ARC ARC F6X9Y4_ORNAN F6X9Y4_ORNAN F6WE73_ORNAN F6WE73_ORNAN TERT TERT CAV1 CAV1 ENSOANP00000023661 ENSOANP00000023661 RELN RELN STAC2 STAC2 AMIGO3 AMIGO3 STAC STAC F7CBG1_ORNAN F7CBG1_ORNAN F6VR07_ORNAN F6VR07_ORNAN F6XH85_ORNAN F6XH85_ORNAN F7ELX3_ORNAN F7ELX3_ORNAN F7G047_ORNAN F7G047_ORNAN PLCG1 PLCG1 F6TQC2_ORNAN F6TQC2_ORNAN F6Y8W8_ORNAN F6Y8W8_ORNAN F6ZQZ9_ORNAN F6ZQZ9_ORNAN F6SCW0_ORNAN F6SCW0_ORNAN K7E6M4_ORNAN K7E6M4_ORNAN AKAP7 AKAP7 K7E6X8_ORNAN K7E6X8_ORNAN AMIGO1 AMIGO1 STIM1-2 STIM1-2 K7E815_ORNAN K7E815_ORNAN PLCG2 PLCG2 K7E8K7_ORNAN K7E8K7_ORNAN K7E8Y5_ORNAN K7E8Y5_ORNAN K7E9C0_ORNAN K7E9C0_ORNAN K7E9W4_ORNAN K7E9W4_ORNAN K7EBR2_ORNAN K7EBR2_ORNAN K7EBU7_ORNAN K7EBU7_ORNAN HTT HTT K7EC26_ORNAN K7EC26_ORNAN K7EC51_ORNAN K7EC51_ORNAN K7ECW3_ORNAN K7ECW3_ORNAN K7ECZ6_ORNAN K7ECZ6_ORNAN K7ED15_ORNAN K7ED15_ORNAN K7EDB3_ORNAN K7EDB3_ORNAN LOC103170562 LOC103170562 CLIP3 CLIP3 K7EDY5_ORNAN K7EDY5_ORNAN K7EDZ7_ORNAN K7EDZ7_ORNAN C2CD5 C2CD5 K7EE78_ORNAN K7EE78_ORNAN WNK3-2 WNK3-2 WNK4 WNK4 K7EGX5_ORNAN K7EGX5_ORNAN CD19 CD19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB1Integrin beta; Belongs to the integrin beta chain family. (819 aa)
PTPN11Uncharacterized protein. (368 aa)
P2RX7Uncharacterized protein. (307 aa)
SLC17A8Solute carrier family 17 member 8. (586 aa)
IGF1Insulin like growth factor 1. (153 aa)
F6UI95_ORNANUncharacterized protein. (848 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SORBS1Sorbin and SH3 domain containing 1. (1312 aa)
F7FZN3_ORNANOrn_Arg_deC_N domain-containing protein. (364 aa)
CHP1Calcineurin like EF-hand protein 1. (195 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (249 aa)
F7BP39_ORNANUncharacterized protein. (193 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (743 aa)
F7D6S0_ORNANP2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (354 aa)
AMIGO2Adhesion molecule with Ig like domain 2. (523 aa)
F6TH95_ORNANG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (93 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (376 aa)
F7B581_ORNANUncharacterized protein; Belongs to the peptidase S1 family. (600 aa)
F6TF38_ORNANUncharacterized protein. (345 aa)
RNF207Ring finger protein 207. (500 aa)
ACE2Angiotensin-converting enzyme. (806 aa)
CLTRNCollectrin domain-containing protein. (261 aa)
KCNE1Uncharacterized protein. (127 aa)
F7AI10_ORNANFibronectin type-III domain-containing protein. (269 aa)
F6UHR1_ORNANSodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (400 aa)
PDPK1Protein kinase domain-containing protein. (280 aa)
VMP1Uncharacterized protein. (106 aa)
F7ALN7_ORNANUncharacterized protein. (373 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (562 aa)
THY1Ig-like domain-containing protein. (129 aa)
WNK2WNK lysine deficient protein kinase 2. (2296 aa)
CA2Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (259 aa)
F7FEI4_ORNANSTAS domain-containing protein. (516 aa)
SRISorcin. (180 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (684 aa)
APPL1Uncharacterized protein. (524 aa)
F7EVG8_ORNANReceptor protein-tyrosine kinase. (1063 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (341 aa)
RNASELUncharacterized protein. (694 aa)
COA8Cytochrome c oxidase assembly factor 8. (148 aa)
CREBL2cAMP responsive element binding protein like 2. (121 aa)
WNK3WNK lysine deficient protein kinase 3. (1798 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (254 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
RAMP3Receptor activity modifying protein 3. (131 aa)
MEF2AMyocyte enhancer factor 2A. (505 aa)
F6W8B0_ORNANUncharacterized protein. (211 aa)
LRRC38Leucine rich repeat containing 38. (207 aa)
CACNB4SH3 domain-containing protein. (473 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (332 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (576 aa)
F6WGS8_ORNANG_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (257 aa)
STIM2Stromal interaction molecule 2. (674 aa)
F7EHS9_ORNANC-X-C motif chemokine. (105 aa)
EDN1Endothelin 1. (204 aa)
CHP2Calcineurin like EF-hand protein 2. (172 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (87 aa)
ABCC8ATP binding cassette subfamily C member 8. (1586 aa)
F6UEH0_ORNANOrn_DAP_Arg_deC domain-containing protein. (148 aa)
R3HDM1R3H domain containing 1. (1096 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (322 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (645 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1487 aa)
LRRC55Leucine rich repeat containing 55. (314 aa)
ACTN2Actinin alpha 2. (865 aa)
STIM1Stromal interaction molecule 1. (591 aa)
PDZK1PDZ domain containing 1. (484 aa)
F6ZIW3_ORNANUncharacterized protein. (55 aa)
F6YRH5_ORNANProtein kinase domain-containing protein. (453 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (912 aa)
F6V2U3_ORNANUncharacterized protein. (116 aa)
FLNAUncharacterized protein. (2640 aa)
F7D453_ORNANPH domain-containing protein. (217 aa)
F7GEP6_ORNANPhosphoinositide phospholipase C. (1097 aa)
F6RE34_ORNANProtein kinase domain-containing protein. (1864 aa)
F7AVI5_ORNANTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (216 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (534 aa)
F7FGE5_ORNANCalpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (310 aa)
CAPN10Uncharacterized protein; Belongs to the peptidase C2 family. (347 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (284 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (224 aa)
F6ZBY6_ORNANUncharacterized protein. (56 aa)
F2RL3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (300 aa)
ANO6Anoctamin. (575 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (702 aa)
F7FHN9_ORNANUncharacterized protein. (82 aa)
F7EC32_ORNANPKD_channel domain-containing protein. (498 aa)
AZIN1Orn_Arg_deC_N domain-containing protein. (296 aa)
CEMIPILEI domain-containing protein. (360 aa)
F7FGH1_ORNANSCY domain-containing protein. (392 aa)
F7DV77_ORNANUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (319 aa)
F7DV18_ORNANUncharacterized protein. (284 aa)
AKAP6A-kinase anchoring protein 6. (2311 aa)
ARCActivity regulated cytoskeleton associated protein. (401 aa)
F6X9Y4_ORNANUncharacterized protein. (281 aa)
F6WE73_ORNANUncharacterized protein. (548 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1101 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (113 aa)
ENSOANP00000023661annotation not available (113 aa)
RELNReelin. (3342 aa)
STAC2SH3 domain-containing protein. (82 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (498 aa)
STACSH3 and cysteine rich domain. (274 aa)
F7CBG1_ORNANAnoctamin. (203 aa)
F6VR07_ORNANProtein kinase domain-containing protein. (259 aa)
F6XH85_ORNANUncharacterized protein. (139 aa)
F7ELX3_ORNANUncharacterized protein. (157 aa)
F7G047_ORNANG8 domain-containing protein. (120 aa)
PLCG1Uncharacterized protein. (265 aa)
F6TQC2_ORNANCAP-Gly domain-containing protein. (207 aa)
F6Y8W8_ORNANUncharacterized protein. (143 aa)
F6ZQZ9_ORNANUncharacterized protein. (291 aa)
F6SCW0_ORNANIon_trans_2 domain-containing protein. (196 aa)
K7E6M4_ORNANUncharacterized protein. (108 aa)
AKAP7AKAP7_NLS domain-containing protein. (180 aa)
K7E6X8_ORNANCation_ATPase_N domain-containing protein. (77 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (436 aa)
STIM1-2Uncharacterized protein. (57 aa)
K7E815_ORNANUncharacterized protein. (215 aa)
PLCG2SH2 domain-containing protein. (238 aa)
K7E8K7_ORNANUncharacterized protein. (66 aa)
K7E8Y5_ORNANUncharacterized protein. (152 aa)
K7E9C0_ORNANUncharacterized protein. (247 aa)
K7E9W4_ORNANILEI domain-containing protein. (155 aa)
K7EBR2_ORNANUncharacterized protein. (117 aa)
K7EBU7_ORNANUncharacterized protein. (92 aa)
HTTUncharacterized protein. (261 aa)
K7EC26_ORNANUncharacterized protein. (97 aa)
K7EC51_ORNANUncharacterized protein. (145 aa)
K7ECW3_ORNANUncharacterized protein. (138 aa)
K7ECZ6_ORNANUncharacterized protein. (113 aa)
K7ED15_ORNANUncharacterized protein. (54 aa)
K7EDB3_ORNANPH domain-containing protein. (104 aa)
LOC103170562SCY domain-containing protein. (101 aa)
CLIP3Uncharacterized protein. (113 aa)
K7EDY5_ORNANUncharacterized protein. (169 aa)
K7EDZ7_ORNANUncharacterized protein. (103 aa)
C2CD5Uncharacterized protein. (329 aa)
K7EE78_ORNANSH3 domain-containing protein. (155 aa)
WNK3-2Uncharacterized protein. (137 aa)
WNK4OSR1_C domain-containing protein. (198 aa)
K7EGX5_ORNANUncharacterized protein. (238 aa)
CD19Uncharacterized protein. (145 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
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