(47 nodes) Aorta development network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (419 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	CNTRL	Uncharacterized protein. (987 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (379 aa)
	F6RX31_ORNAN	Uncharacterized protein. (1763 aa)
	COL3A1	Collagen type III alpha 1 chain. (1459 aa)
	PLXND1	Uncharacterized protein. (764 aa)
	F7GEJ3_ORNAN	Plexin_cytopl domain-containing protein. (616 aa)
	FKBP10	Peptidylprolyl isomerase. (581 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (418 aa)
	F7AV83_ORNAN	Uncharacterized protein. (52 aa)
	PRDM1	PR/SET domain 1. (858 aa)
	F7DX94_ORNAN	Uncharacterized protein. (558 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2084 aa)
	F6R437_ORNAN	Uncharacterized protein. (653 aa)
	F6YB22_ORNAN	Uncharacterized protein. (231 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (332 aa)
	DCTN5	Dynactin subunit 5. (182 aa)
	NKX3-1	NK3 homeobox 1. (180 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	PROX1	Prospero homeobox 1. (781 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	F6YC81_ORNAN	Ig-like domain-containing protein. (118 aa)
	ROBO2	Roundabout guidance receptor 2. (1324 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (831 aa)
	NPRL3	Uncharacterized protein. (199 aa)
	F7DXH0_ORNAN	Uncharacterized protein. (351 aa)
	ADAMTS9	Uncharacterized protein. (166 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (109 aa)
	SMAD6	MH2 domain-containing protein. (177 aa)
	F7EC32_ORNAN	PKD_channel domain-containing protein. (498 aa)
	ROBO1	Roundabout guidance receptor 1. (1491 aa)
	SEC24B	Uncharacterized protein. (1133 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
	EFEMP2	EGF containing fibulin extracellular matrix protein 2. (319 aa)
	F6W506_ORNAN	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (282 aa)
	F6YDQ6_ORNAN	Uncharacterized protein. (207 aa)
	F7FX22_ORNAN	Sec23_trunk domain-containing protein. (135 aa)
	F7G1H7_ORNAN	Uncharacterized protein. (254 aa)
	F6Z3R7_ORNAN	Uncharacterized protein. (270 aa)
	TAB1	PPM-type phosphatase domain-containing protein. (148 aa)
	K7E947_ORNAN	Uncharacterized protein. (187 aa)
	K7ECF0_ORNAN	Uncharacterized protein. (100 aa)
	K7ECL9_ORNAN	EGF-like domain-containing protein. (54 aa)
	K7EDJ7_ORNAN	Pep_M12B_propep domain-containing protein. (187 aa)
	K7EGZ8_ORNAN	Uncharacterized protein. (345 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMPR1A	ENSOANP00000006281	ENSOANP00000014182	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.488
ACVRL1	SMAD6	ENSOANP00000006281	ENSOANP00000021386	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	MH2 domain-containing protein.	0.630
ADAMTS9	K7EDJ7_ORNAN	ENSOANP00000019534	ENSOANP00000031604	Uncharacterized protein.	Pep_M12B_propep domain-containing protein.	0.899
BMPR1A	ACVRL1	ENSOANP00000014182	ENSOANP00000006281	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.488
BMPR1A	LEP	ENSOANP00000014182	ENSOANP00000001265	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.406
BMPR1A	SMAD6	ENSOANP00000014182	ENSOANP00000021386	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	MH2 domain-containing protein.	0.726
CHD7	F6R437_ORNAN	ENSOANP00000008005	ENSOANP00000008006	Chromodomain helicase DNA binding protein 7.	Uncharacterized protein.	0.900
CNTRL	F7DX94_ORNAN	ENSOANP00000001753	ENSOANP00000007058	Uncharacterized protein.	Uncharacterized protein.	0.922
CNTRL	F7DXH0_ORNAN	ENSOANP00000001753	ENSOANP00000019023	Uncharacterized protein.	Uncharacterized protein.	0.954
CNTRL	K7ECF0_ORNAN	ENSOANP00000001753	ENSOANP00000031207	Uncharacterized protein.	Uncharacterized protein.	0.524
COL3A1	F6Z3R7_ORNAN	ENSOANP00000004829	ENSOANP00000027253	Collagen type III alpha 1 chain.	Uncharacterized protein.	0.458
COL3A1	FKBP10	ENSOANP00000004829	ENSOANP00000006088	Collagen type III alpha 1 chain.	Peptidylprolyl isomerase.	0.400
DLL4	JAG1	ENSOANP00000019927	ENSOANP00000013388	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.410
EFEMP2	FKBP10	ENSOANP00000023332	ENSOANP00000006088	EGF containing fibulin extracellular matrix protein 2.	Peptidylprolyl isomerase.	0.726
F6R437_ORNAN	CHD7	ENSOANP00000008006	ENSOANP00000008005	Uncharacterized protein.	Chromodomain helicase DNA binding protein 7.	0.900
F6RX31_ORNAN	K7EDJ7_ORNAN	ENSOANP00000003599	ENSOANP00000031604	Uncharacterized protein.	Pep_M12B_propep domain-containing protein.	0.900
F6YB22_ORNAN	NPRL3	ENSOANP00000008101	ENSOANP00000018022	Uncharacterized protein.	Uncharacterized protein.	0.934
F6YC81_ORNAN	ROBO1	ENSOANP00000015081	ENSOANP00000021770	Ig-like domain-containing protein.	Roundabout guidance receptor 1.	0.900
F6YC81_ORNAN	ROBO2	ENSOANP00000015081	ENSOANP00000015083	Ig-like domain-containing protein.	Roundabout guidance receptor 2.	0.900
F6YDQ6_ORNAN	K7EGZ8_ORNAN	ENSOANP00000025921	ENSOANP00000032805	Uncharacterized protein.	Uncharacterized protein.	0.935