STRINGSTRING
TMEM130 TMEM130 F6ZXX6_ORNAN F6ZXX6_ORNAN SORL1 SORL1 TRIB2 TRIB2 AIDA AIDA DUSP10 DUSP10 F7EVG8_ORNAN F7EVG8_ORNAN F7FAD5_ORNAN F7FAD5_ORNAN F6QBI6_ORNAN F6QBI6_ORNAN NTF3 NTF3 PSEN1 PSEN1 F6YIV5_ORNAN F6YIV5_ORNAN F6YLQ5_ORNAN F6YLQ5_ORNAN F7F448_ORNAN F7F448_ORNAN EZH2 EZH2 K7EHE1_ORNAN K7EHE1_ORNAN K7EGN4_ORNAN K7EGN4_ORNAN K7EGI3_ORNAN K7EGI3_ORNAN K7EGA3_ORNAN K7EGA3_ORNAN K7EFY1_ORNAN K7EFY1_ORNAN K7EFP4_ORNAN K7EFP4_ORNAN RASGRP1 RASGRP1 K7EF74_ORNAN K7EF74_ORNAN K7EF70_ORNAN K7EF70_ORNAN K7EF27_ORNAN K7EF27_ORNAN K7EEK9_ORNAN K7EEK9_ORNAN K7ECZ6_ORNAN K7ECZ6_ORNAN K7ECB5_ORNAN K7ECB5_ORNAN ERN2 ERN2 MAP4K2 MAP4K2 K7EAL4_ORNAN K7EAL4_ORNAN ERN1-2 ERN1-2 K7E9F7_ORNAN K7E9F7_ORNAN RPS3 RPS3 K7E865_ORNAN K7E865_ORNAN K7E7U1_ORNAN K7E7U1_ORNAN K7E7K8_ORNAN K7E7K8_ORNAN K7E7E1_ORNAN K7E7E1_ORNAN PIK3R5 PIK3R5 K7E6L1_ORNAN K7E6L1_ORNAN F6SLU2_ORNAN F6SLU2_ORNAN F6QIR6_ORNAN F6QIR6_ORNAN F6ZFJ1_ORNAN F6ZFJ1_ORNAN LRRK2 LRRK2 NF1 NF1 F6YY17_ORNAN F6YY17_ORNAN F7EB41_ORNAN F7EB41_ORNAN F7ETK2_ORNAN F7ETK2_ORNAN F7EUH3_ORNAN F7EUH3_ORNAN F7BN07_ORNAN F7BN07_ORNAN FGD2 FGD2 F7CBH6_ORNAN F7CBH6_ORNAN F7CGZ1_ORNAN F7CGZ1_ORNAN PDGFC PDGFC FZD5 FZD5 MAP2K7 MAP2K7 HIPK3 HIPK3 ENSOANP00000023661 ENSOANP00000023661 CAV1 CAV1 SOS1 SOS1 PIK3CB PIK3CB TENM1 TENM1 MAP3K13 MAP3K13 F6UK30_ORNAN F6UK30_ORNAN PTPRC PTPRC DUSP19 DUSP19 FGF1 FGF1 AGT AGT HMGCR HMGCR MAP2K5 MAP2K5 NOD2 NOD2 CDK5RAP3 CDK5RAP3 F7E6U2_ORNAN F7E6U2_ORNAN F7BNL7_ORNAN F7BNL7_ORNAN PTPN6 PTPN6 FGF18 FGF18 RNF217 RNF217 SASH1 SASH1 F7BHZ6_ORNAN F7BHZ6_ORNAN HGS HGS DAB2IP DAB2IP DTNBP1 DTNBP1 TRAF6 TRAF6 IRAK1 IRAK1 PDCD10 PDCD10 AJUBA AJUBA EGFR EGFR IL1B IL1B F6UGB6_ORNAN F6UGB6_ORNAN F6RUJ4_ORNAN F6RUJ4_ORNAN F6YC45_ORNAN F6YC45_ORNAN MAP3K5 MAP3K5 HTR2B HTR2B F7ERZ5_ORNAN F7ERZ5_ORNAN FLT1 FLT1 MAP3K7 MAP3K7 FZD4 FZD4 NOX4 NOX4 PTPN1 PTPN1 BMP2 BMP2 TSG101 TSG101 F7BT31_ORNAN F7BT31_ORNAN TRIB1 TRIB1 DVL3 DVL3 ERN1 ERN1 TNFRSF11A TNFRSF11A PTPRJ PTPRJ F7BZS1_ORNAN F7BZS1_ORNAN EDN1 EDN1 PTK2B PTK2B F7EQD4_ORNAN F7EQD4_ORNAN DKK1 DKK1 EPGN EPGN PDGFB PDGFB IRAK3 IRAK3 P2RX7 P2RX7 F6PUW8_ORNAN F6PUW8_ORNAN F6PVL6_ORNAN F6PVL6_ORNAN KSR1 KSR1 LYN LYN SFRP2 SFRP2 ERP29 ERP29 SH2B3 SH2B3 SPRY2 SPRY2 TNFSF11 TNFSF11 SMPD1 SMPD1 F7BI33_ORNAN F7BI33_ORNAN F7A182_ORNAN F7A182_ORNAN MAP3K11 MAP3K11 ADIPOQ ADIPOQ VEGFA VEGFA ADAM8 ADAM8 KIT KIT AKAP13 AKAP13 PAQR3 PAQR3 F7DQY6_ORNAN F7DQY6_ORNAN PIK3CG PIK3CG MAP3K4 MAP3K4 THBS1 THBS1 F6UAW2_ORNAN F6UAW2_ORNAN INPP5K INPP5K SPRY4 SPRY4 F6WAZ2_ORNAN F6WAZ2_ORNAN F6RW09_ORNAN F6RW09_ORNAN F6TQ56_ORNAN F6TQ56_ORNAN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TMEM130PKD domain-containing protein. (420 aa)
F6ZXX6_ORNANUncharacterized protein. (306 aa)
SORL1Sortilin related receptor 1. (2116 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
AIDAAxin interactor, dorsalization associated. (307 aa)
DUSP10Dual specificity phosphatase 10. (480 aa)
F7EVG8_ORNANReceptor protein-tyrosine kinase. (1063 aa)
F7FAD5_ORNANDH domain-containing protein. (419 aa)
F6QBI6_ORNANUncharacterized protein. (229 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (179 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (341 aa)
F6YIV5_ORNANDIX domain-containing protein. (543 aa)
F6YLQ5_ORNANUncharacterized protein. (427 aa)
F7F448_ORNANUncharacterized protein. (921 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
K7EHE1_ORNANSKICH domain-containing protein. (77 aa)
K7EGN4_ORNANUncharacterized protein. (135 aa)
K7EGI3_ORNANUncharacterized protein. (72 aa)
K7EGA3_ORNANUncharacterized protein. (112 aa)
K7EFY1_ORNANUncharacterized protein. (203 aa)
K7EFP4_ORNANUncharacterized protein. (71 aa)
RASGRP1Ras-GEF domain-containing protein. (158 aa)
K7EF74_ORNANUncharacterized protein. (54 aa)
K7EF70_ORNANUncharacterized protein. (86 aa)
K7EF27_ORNANUncharacterized protein. (228 aa)
K7EEK9_ORNANUncharacterized protein. (95 aa)
K7ECZ6_ORNANUncharacterized protein. (113 aa)
K7ECB5_ORNANTeneurin N-terminal domain-containing protein. (170 aa)
ERN2Uncharacterized protein. (88 aa)
MAP4K2Uncharacterized protein. (75 aa)
K7EAL4_ORNANProtein kinase domain-containing protein. (96 aa)
ERN1-2Uncharacterized protein. (67 aa)
K7E9F7_ORNANUncharacterized protein. (234 aa)
RPS3KH type-2 domain-containing protein. (143 aa)
K7E865_ORNANUncharacterized protein. (53 aa)
K7E7U1_ORNANUncharacterized protein. (81 aa)
K7E7K8_ORNANPkinase_Tyr domain-containing protein. (233 aa)
K7E7E1_ORNANUncharacterized protein. (64 aa)
PIK3R5Uncharacterized protein. (286 aa)
K7E6L1_ORNANUncharacterized protein. (1388 aa)
F6SLU2_ORNANProtein kinase domain-containing protein. (492 aa)
F6QIR6_ORNANUncharacterized protein. (274 aa)
F6ZFJ1_ORNANUncharacterized protein. (105 aa)
LRRK2COR domain-containing protein. (401 aa)
NF1Ras-GAP domain-containing protein. (1467 aa)
F6YY17_ORNANUEV domain-containing protein. (103 aa)
F7EB41_ORNANUncharacterized protein. (2219 aa)
F7ETK2_ORNANProtein kinase domain-containing protein. (176 aa)
F7EUH3_ORNANUncharacterized protein. (212 aa)
F7BN07_ORNANTyrosine-protein phosphatase domain-containing protein. (196 aa)
FGD2Uncharacterized protein. (272 aa)
F7CBH6_ORNANUncharacterized protein. (875 aa)
F7CGZ1_ORNANDickkopf_N domain-containing protein. (221 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (305 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (404 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (280 aa)
HIPK3Homeodomain interacting protein kinase 3. (1225 aa)
ENSOANP00000023661annotation not available (113 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (113 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1214 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1034 aa)
TENM1Tox-GHH domain-containing protein. (1077 aa)
MAP3K13Protein kinase domain-containing protein. (527 aa)
F6UK30_ORNANUncharacterized protein. (1116 aa)
PTPRCUncharacterized protein. (548 aa)
DUSP19Uncharacterized protein. (142 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (488 aa)
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase. (775 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (368 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1021 aa)
CDK5RAP3Uncharacterized protein. (150 aa)
F7E6U2_ORNANProtein kinase domain-containing protein. (616 aa)
F7BNL7_ORNANHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (437 aa)
PTPN6Protein tyrosine phosphatase non-receptor type 6. (420 aa)
FGF18Uncharacterized protein; Belongs to the heparin-binding growth factors family. (98 aa)
RNF217Uncharacterized protein. (300 aa)
SASH1SAM and SH3 domain containing 1. (1118 aa)
F7BHZ6_ORNANUncharacterized protein. (309 aa)
HGSUncharacterized protein. (158 aa)
DAB2IPDAB2 interacting protein. (991 aa)
DTNBP1Dystrobrevin binding protein 1. (354 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (685 aa)
PDCD10Programmed cell death 10. (212 aa)
AJUBAUncharacterized protein. (121 aa)
EGFRReceptor protein-tyrosine kinase. (1215 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (290 aa)
F6UGB6_ORNANEGF-like domain-containing protein. (127 aa)
F6RUJ4_ORNANKH type-2 domain-containing protein. (211 aa)
F6YC45_ORNANUncharacterized protein. (100 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1228 aa)
HTR2B5-hydroxytryptamine receptor 2B. (482 aa)
F7ERZ5_ORNANCNH domain-containing protein. (556 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1317 aa)
MAP3K7Protein kinase domain-containing protein. (506 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (507 aa)
NOX4NADPH oxidase 4. (508 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (376 aa)
BMP2Bone morphogenetic protein 2. (394 aa)
TSG101SB domain-containing protein. (230 aa)
F7BT31_ORNANPDZ domain-containing protein. (230 aa)
TRIB1Tribbles pseudokinase 1. (256 aa)
DVL3Dishevelled segment polarity protein 3. (491 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (900 aa)
TNFRSF11AUncharacterized protein. (484 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1245 aa)
F7BZS1_ORNANDH domain-containing protein. (462 aa)
EDN1Endothelin 1. (204 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (749 aa)
F7EQD4_ORNANUncharacterized protein. (210 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (260 aa)
EPGNEpithelial mitogen. (114 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (212 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (615 aa)
P2RX7Uncharacterized protein. (307 aa)
F6PUW8_ORNANUncharacterized protein. (385 aa)
F6PVL6_ORNANUncharacterized protein. (918 aa)
KSR1Kinase suppressor of ras 1. (795 aa)
LYNTyrosine-protein kinase. (514 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
ERP29Endoplasmic reticulum protein 29. (214 aa)
SH2B3SH2B adaptor protein 3. (575 aa)
SPRY2Sprouty RTK signaling antagonist 2. (344 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (244 aa)
SMPD1Metallophos domain-containing protein. (201 aa)
F7BI33_ORNANIg-like domain-containing protein. (259 aa)
F7A182_ORNANUncharacterized protein; Belongs to the protein kinase superfamily. (403 aa)
MAP3K11Uncharacterized protein. (76 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (249 aa)
VEGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (215 aa)
ADAM8Uncharacterized protein. (269 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
AKAP13Uncharacterized protein. (727 aa)
PAQR3Progestin and adipoQ receptor family member 3. (251 aa)
F7DQY6_ORNANUncharacterized protein. (1393 aa)
PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1053 aa)
MAP3K4Uncharacterized protein. (743 aa)
THBS1Thrombospondin 1. (902 aa)
F6UAW2_ORNANUncharacterized protein. (176 aa)
INPP5KIPPc domain-containing protein. (460 aa)
SPRY4Sprouty RTK signaling antagonist 4. (213 aa)
F6WAZ2_ORNANProtein kinase domain-containing protein. (431 aa)
F6RW09_ORNANUncharacterized protein. (334 aa)
F6TQ56_ORNANUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1008 aa)
Your Current Organism:
Ornithorhynchus anatinus
NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus
Server load: medium (66%) [HD]