(83 nodes) Homologous chromosome segregation network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F7EMW0_ORNAN	Uncharacterized protein. (86 aa)
	PSMC3IP	Uncharacterized protein. (167 aa)
	K7E7Q5_ORNAN	Uncharacterized protein. (165 aa)
	K7E7U9_ORNAN	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (77 aa)
	K7E960_ORNAN	Uncharacterized protein. (152 aa)
	MSH5	MutS_IV domain-containing protein. (250 aa)
	BAG6	Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (327 aa)
	K7EG55_ORNAN	ATPase_AAA_core domain-containing protein. (80 aa)
	K7EH15_ORNAN	Uncharacterized protein. (149 aa)
	K7EH41_ORNAN	Uncharacterized protein. (127 aa)
	K7EHA5_ORNAN	Uncharacterized protein. (139 aa)
	K7EHV5_ORNAN	Uncharacterized protein. (251 aa)
	ZCWPW1	Uncharacterized protein. (217 aa)
	K7EI67_ORNAN	Uncharacterized protein. (347 aa)
	K7EI84_ORNAN	DNA_MISMATCH_REPAIR_2 domain-containing protein. (104 aa)
	F7CWZ1_ORNAN	DNA_mis_repair domain-containing protein. (412 aa)
	SUN1	SUN domain-containing protein. (932 aa)
	ATM	FAT domain-containing protein. (1029 aa)
	F7CIQ0_ORNAN	Uncharacterized protein. (2331 aa)
	F7CX73_ORNAN	Uncharacterized protein. (546 aa)
	F7FHY2_ORNAN	Uncharacterized protein. (934 aa)
	F6S6V8_ORNAN	DNA_MISMATCH_REPAIR_2 domain-containing protein. (295 aa)
	MEIOB	Meiosis specific with OB-fold. (472 aa)
	F6YYW8_ORNAN	Uncharacterized protein. (515 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (405 aa)
	F7F164_ORNAN	Uncharacterized protein. (264 aa)
	CCNB1IP1	Cyclin B1 interacting protein 1. (277 aa)
	PTTG1	Uncharacterized protein. (201 aa)
	K7EEW3_ORNAN	Uncharacterized protein. (389 aa)
	K7EEV0_ORNAN	Uncharacterized protein. (612 aa)
	K7EEH4_ORNAN	Uncharacterized protein. (122 aa)
	ESPL1	Peptidase C50 domain-containing protein. (170 aa)
	K7EDI5_ORNAN	Uncharacterized protein. (209 aa)
	LOC100682168	Uncharacterized protein. (521 aa)
	K7ED08_ORNAN	Uncharacterized protein. (559 aa)
	K7ECS5_ORNAN	Uncharacterized protein. (129 aa)
	STAG3	STAG domain-containing protein. (104 aa)
	K7EC64_ORNAN	Uncharacterized protein. (278 aa)
	K7EC62_ORNAN	Uncharacterized protein. (102 aa)
	K7EBP5_ORNAN	CENP-C_C domain-containing protein. (578 aa)
	LOC103170269	Uncharacterized protein. (511 aa)
	K7EBA7_ORNAN	Uncharacterized protein. (110 aa)
	K7EB13_ORNAN	Uncharacterized protein. (119 aa)
	K7EF19_ORNAN	Uncharacterized protein. (102 aa)
	K7EAL5_ORNAN	FAT domain-containing protein. (153 aa)
	K7EA92_ORNAN	FAT domain-containing protein. (108 aa)
	K7E9X2_ORNAN	Uncharacterized protein. (110 aa)
	K7E9S0_ORNAN	Uncharacterized protein. (594 aa)
	F6SQB3_ORNAN	SCD domain-containing protein. (1002 aa)
	RNF212B	Ring finger protein 212B. (258 aa)
	PLK1	Polo like kinase 1. (479 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (446 aa)
	PTTG1-2	annotation not available (201 aa)
	SYCE2	Uncharacterized protein. (165 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (392 aa)
	MEIOC	Uncharacterized protein. (729 aa)
	F6TP73_ORNAN	Uncharacterized protein. (444 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (624 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (333 aa)
	F7FCN0_ORNAN	Uncharacterized protein. (283 aa)
	MLH3	MutL_C domain-containing protein. (353 aa)
	F6ZYZ2_ORNAN	Uncharacterized protein. (573 aa)
	F7F809_ORNAN	Uncharacterized protein. (86 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (423 aa)
	F7BBC0_ORNAN	Uncharacterized protein. (264 aa)
	MLH1	MutL homolog 1. (747 aa)
	F7EMV6_ORNAN	TAN domain-containing protein. (316 aa)
	F7EMV0_ORNAN	TAN domain-containing protein. (121 aa)
	F6PLB6_ORNAN	DNA_MISMATCH_REPAIR_2 domain-containing protein. (522 aa)
	MSH4	MutS_II domain-containing protein. (190 aa)
	SPATA22	Spermatogenesis associated 22. (334 aa)
	FANCD2	Uncharacterized protein. (338 aa)
	F7G0Q4_ORNAN	LZ3wCH domain-containing protein. (58 aa)
	HORMAD1	HORMA domain-containing protein. (371 aa)
	F7F5D6_ORNAN	Uncharacterized protein. (277 aa)
	F6ZKL7_ORNAN	MUTSd domain-containing protein. (241 aa)
	MAJIN	Uncharacterized protein. (117 aa)
	F6TBT7_ORNAN	RING-type domain-containing protein. (187 aa)
	F6U4G4_ORNAN	KASH_CCD domain-containing protein. (361 aa)
	F6T9B5_ORNAN	CW-type domain-containing protein. (291 aa)
	F6Y2X1_ORNAN	Uncharacterized protein. (146 aa)
	MEIKIN	Uncharacterized protein. (334 aa)
	K7E790_ORNAN	Uncharacterized protein. (141 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DMC1	ENSOANP00000009993	ENSOANP00000016750	FAT domain-containing protein.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.432
ATM	F7EMV0_ORNAN	ENSOANP00000009993	ENSOANP00000024948	FAT domain-containing protein.	TAN domain-containing protein.	0.901
ATM	F7EMV6_ORNAN	ENSOANP00000009993	ENSOANP00000024947	FAT domain-containing protein.	TAN domain-containing protein.	0.940
ATM	FANCD2	ENSOANP00000009993	ENSOANP00000025994	FAT domain-containing protein.	Uncharacterized protein.	0.417
ATM	K7E960_ORNAN	ENSOANP00000009993	ENSOANP00000030067	FAT domain-containing protein.	Uncharacterized protein.	0.858
ATM	K7EHV5_ORNAN	ENSOANP00000009993	ENSOANP00000033112	FAT domain-containing protein.	Uncharacterized protein.	0.951
ATM	MEIOB	ENSOANP00000009993	ENSOANP00000004638	FAT domain-containing protein.	Meiosis specific with OB-fold.	0.484
ATM	MLH1	ENSOANP00000009993	ENSOANP00000024092	FAT domain-containing protein.	MutL homolog 1.	0.602
ATM	MRE11	ENSOANP00000009993	ENSOANP00000016491	FAT domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.974
BAG6	F7F809_ORNAN	ENSOANP00000032214	ENSOANP00000019585	Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...]	Uncharacterized protein.	0.666
CCNB1IP1	F6TBT7_ORNAN	ENSOANP00000001628	ENSOANP00000028522	Cyclin B1 interacting protein 1.	RING-type domain-containing protein.	0.529
CCNB1IP1	F7CWZ1_ORNAN	ENSOANP00000001628	ENSOANP00000011166	Cyclin B1 interacting protein 1.	DNA_mis_repair domain-containing protein.	0.461
CCNB1IP1	MLH1	ENSOANP00000001628	ENSOANP00000024092	Cyclin B1 interacting protein 1.	MutL homolog 1.	0.584
CCNB1IP1	MLH3	ENSOANP00000001628	ENSOANP00000018348	Cyclin B1 interacting protein 1.	MutL_C domain-containing protein.	0.461
CCNB1IP1	SPO11	ENSOANP00000001628	ENSOANP00000014733	Cyclin B1 interacting protein 1.	SPO11 initiator of meiotic double stranded breaks.	0.549
CCNE1	CCNE2	ENSOANP00000022316	ENSOANP00000003512	Cyclin E1; Belongs to the cyclin family.	Cyclin E2; Belongs to the cyclin family.	0.518
CCNE2	CCNE1	ENSOANP00000003512	ENSOANP00000022316	Cyclin E2; Belongs to the cyclin family.	Cyclin E1; Belongs to the cyclin family.	0.518
DMC1	ATM	ENSOANP00000016750	ENSOANP00000009993	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	FAT domain-containing protein.	0.432
DMC1	F6PLB6_ORNAN	ENSOANP00000016750	ENSOANP00000025217	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.496
DMC1	F6S6V8_ORNAN	ENSOANP00000016750	ENSOANP00000006491	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.520