(53 nodes) Negative regulation of gene expression, epigenetic network (Ornithorhynchus anatinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMCHD1	SMC hinge domain-containing protein. (1192 aa)
	F6UB28_ORNAN	Uncharacterized protein. (209 aa)
	F6TDK0_ORNAN	DUF3715 domain-containing protein. (439 aa)
	MBD3	MBD domain-containing protein. (302 aa)
	F7DN30_ORNAN	Uncharacterized protein. (924 aa)
	SIRT1	Uncharacterized protein. (226 aa)
	F6Q7U6_ORNAN	YTH domain-containing protein. (293 aa)
	HELLS	Helicase, lymphoid specific. (826 aa)
	BMI1	RING-type domain-containing protein. (326 aa)
	F7BUB6_ORNAN	Rif1_N domain-containing protein. (2379 aa)
	ZNFX1	Uncharacterized protein. (1135 aa)
	F6XDM8_ORNAN	Uncharacterized protein. (155 aa)
	K7E950_ORNAN	IF rod domain-containing protein. (195 aa)
	K7EC38_ORNAN	DMAP-interaction domain-containing protein. (210 aa)
	EZH1	CXC domain-containing protein. (175 aa)
	F6SFI2_ORNAN	LTD domain-containing protein. (111 aa)
	EPC1	Enhancer of polycomb homolog. (813 aa)
	F6PPK5_ORNAN	Uncharacterized protein. (340 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	HAT1	Histone acetyltransferase 1. (418 aa)
	SIRT6	Sirtuin 6. (269 aa)
	MPHOSPH8	M-phase phosphoprotein 8. (781 aa)
	DOT1L	Uncharacterized protein. (1217 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (519 aa)
	TASOR	Uncharacterized protein. (904 aa)
	MECP2	Methyl-CpG binding protein 2. (499 aa)
	FAM172A	Family with sequence similarity 172 member A. (373 aa)
	LMNB1	IF rod domain-containing protein; Belongs to the intermediate filament family. (328 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (468 aa)
	F6PG93_ORNAN	BAH domain-containing protein. (456 aa)
	MACROH2A2	H2A histone family member Y2; Belongs to the histone H2A family. (316 aa)
	DNMT1	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1090 aa)
	CENPV	GFA domain-containing protein. (142 aa)
	LMNA	IF rod domain-containing protein; Belongs to the intermediate filament family. (346 aa)
	F6WFF3_ORNAN	CW-type domain-containing protein. (1026 aa)
	F6X9U3_ORNAN	SAM domain-containing protein. (837 aa)
	MACROH2A1	Histone H2A; Belongs to the histone H2A family. (289 aa)
	RB1	Uncharacterized protein. (725 aa)
	F7EMX5_ORNAN	Uncharacterized protein. (612 aa)
	F7ECP2_ORNAN	Uncharacterized protein; Belongs to the intermediate filament family. (225 aa)
	F7G1G1_ORNAN	DBF4-type domain-containing protein. (349 aa)
	F7ANW1_ORNAN	PRC2_HTH_1 domain-containing protein. (213 aa)
	F6RMU9_ORNAN	Uncharacterized protein. (214 aa)
	F6YPQ6_ORNAN	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (341 aa)
	K7EHM9_ORNAN	Uncharacterized protein. (74 aa)
	K7EGF8_ORNAN	Histone-lysine N-methyltransferase, H3 lysine-79 specific. (142 aa)
	K7EG33_ORNAN	MBD domain-containing protein. (126 aa)
	K7EFV8_ORNAN	Uncharacterized protein. (458 aa)
	RIF1	Uncharacterized protein. (89 aa)
	K7ECV0_ORNAN	Uncharacterized protein. (83 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
	F6YIV5_ORNAN	DIX domain-containing protein. (543 aa)
	MBD2	MBD_C domain-containing protein. (109 aa)

Your Current Organism:

Ornithorhynchus anatinus

NCBI taxonomy Id: 9258
Other names: O. anatinus, Platypus anatinus, duck-billed platypus, duckbill platypus, platypus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMI1	EZH1	ENSOANP00000009061	ENSOANP00000029612	RING-type domain-containing protein.	CXC domain-containing protein.	0.537
BMI1	EZH2	ENSOANP00000009061	ENSOANP00000000475	RING-type domain-containing protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.795
BMI1	F7ANW1_ORNAN	ENSOANP00000009061	ENSOANP00000027206	RING-type domain-containing protein.	PRC2_HTH_1 domain-containing protein.	0.623
BMI1	MPHOSPH8	ENSOANP00000009061	ENSOANP00000014346	RING-type domain-containing protein.	M-phase phosphoprotein 8.	0.505
DNMT1	EZH1	ENSOANP00000019393	ENSOANP00000029612	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	CXC domain-containing protein.	0.673
DNMT1	EZH2	ENSOANP00000019393	ENSOANP00000000475	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.904
DNMT1	F7ANW1_ORNAN	ENSOANP00000019393	ENSOANP00000027206	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	PRC2_HTH_1 domain-containing protein.	0.718
DNMT1	K7EC38_ORNAN	ENSOANP00000019393	ENSOANP00000031095	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	DMAP-interaction domain-containing protein.	0.900
DNMT1	MBD2	ENSOANP00000019393	ENSOANP00000002857	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	MBD_C domain-containing protein.	0.457
DNMT1	MBD3	ENSOANP00000019393	ENSOANP00000005824	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	MBD domain-containing protein.	0.457
DNMT1	MECP2	ENSOANP00000019393	ENSOANP00000017465	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Methyl-CpG binding protein 2.	0.588
DNMT1	SIRT1	ENSOANP00000019393	ENSOANP00000007323	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Uncharacterized protein.	0.475
DOT1L	F6YPQ6_ORNAN	ENSOANP00000015878	ENSOANP00000028686	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.936
DOT1L	K7EGF8_ORNAN	ENSOANP00000015878	ENSOANP00000032615	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.916
DOT1L	SIRT1	ENSOANP00000015878	ENSOANP00000007323	Uncharacterized protein.	Uncharacterized protein.	0.540
EPC1	EZH1	ENSOANP00000009652	ENSOANP00000029612	Enhancer of polycomb homolog.	CXC domain-containing protein.	0.521
EPC1	EZH2	ENSOANP00000009652	ENSOANP00000000475	Enhancer of polycomb homolog.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.580
EPC1	F7ANW1_ORNAN	ENSOANP00000009652	ENSOANP00000027206	Enhancer of polycomb homolog.	PRC2_HTH_1 domain-containing protein.	0.580
EZH1	BMI1	ENSOANP00000029612	ENSOANP00000009061	CXC domain-containing protein.	RING-type domain-containing protein.	0.537
EZH1	DNMT1	ENSOANP00000029612	ENSOANP00000019393	CXC domain-containing protein.	DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.673